Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings
Lupus
This medicine should be used with caution due to the increased risk of lupus (systemic and cutaneous). Report any unusual signs and symptoms such as extreme tiredness, painful joints, rashes, lesions on the skin, etc. to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Liver disease
This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Vitamin B-12 Deficiency
Long-term treatment with this medicine may decrease the absorption of Vitamin B-12 in the body. Close monitoring of vitamin B12 levels, appropriate supplementation, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Cardiovascular diseases
This medicine should be used with extreme caution in patients with a history of stroke, blood clotting disorders, and other disorders of the heart and blood vessels due to the increased risk of worsening of the patient's condition. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Diabetes
This medicine should be used with caution in patients suffering from diabetes due to the increased risk of altered blood sugar levels. Close monitoring of blood glucose levels is recommended for these patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Changes in electrolyte levels
This medicine should be used with caution due to the increased risk of a change in electrolyte levels (low magnesium levels, low potassium levels, etc.) Close monitoring of electrolyte levels, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Driving or Operating machinery
This medicine may cause symptoms such as moderate-to-severe drowsiness, unusual tiredness or weakness, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
Leukopenia
This medicine should be used with caution due to the increased risk of leukopenia (decreased white blood cell count). Report any symptoms such as fever with chills, sore throat, mouth ulcers, etc. to the doctor immediately. Close monitoring of clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Use in elderly
This medicine should be used with caution in the elderly patients due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Menstrual abnormalities
Use of this medicine has been associated with abnormalities in the menstrual cycle. Contact your doctor if the regular periods are excessively delayed. Replacement with a suitable alternative may be necessary in some cases.
Clostridium difficile-associated Diarrhea
Use of this medicine has been associated with Clostridium difficile-associated diarrhea in some cases. This risk is especially higher in patients with a history of gastrointestinal diseases. Report any symptoms such as a severe and persistent diarrhea, abdominal cramps, etc. to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.