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Rekool-L 25 Tablet
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Rekool-L 25 Tablet

Manufactured byALEMBIC LTD
ContainsLevosulpiride (25 mg) + Rabeprazole (20 mg)
Description
Rekool-L 25 Tablet is a combination medicine which may be used for the treatment of gastroesophageal reflux disease. It may also be used for the treatment of other gastric conditions such as duodenal ulcers, irritable bowel syndrome, chronic gastritis, etc. based on the clinical condition of the patient.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Rekool-L 25 Tablet

  • Headache
  • Altered sense of taste
  • Runny Nose and Cough
  • Diarrhea
  • Nausea or vomiting
  • Skin Rash
  • Changes in weight
  • Drowsiness
  • Breast tenderness
  • Irregular menstrual periods
  • Enlargement of breasts in males
  • Constipation
  • Abdominal pain and cramps
  • Sleeplessness
  • Unusual tiredness and weakness
  • Increased salivation
  • Decrease in sexual drive
  • Fever
  • Excessive sweating
  • Change in heart rate

Uses of Rekool-L 25 Tablet

What is it prescribed for?

  • Gastroesophageal Reflux Disease
  • Chronic gastritis
  • Duodenal Ulcer
  • Irritable bowel syndrome
  • Zollinger-Ellison Syndrome
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 1 to 2 hours of oral administration.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, fainting, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to rabeprazole, any other benzimidazoles, levosulpiride, or any other inactive ingredients present along with these medicines.

Epilepsy

This medicine is not recommended for use in patients suffering from epilepsy due to the increased risk of worsening of the patient's condition.

Bipolar disorder

This medicine is not recommended for use in patients suffering from bipolar disorder, marked by frequent episodes of anxiety, agitation, depression, hallucinations etc., due to the increased risk of worsening of the patient's condition.

Pheochromocytoma

This medicine is not recommended for use in patients suffering from pheochromocytoma since it may worsen the patient's condition.

Gastrointestinal perforation

This medicine is not recommended for use in patients suffering from a perforation or obstruction of the gastrointestinal tract since it may worsen the patient's condition.

Breast cancer

This medicine is not recommended for use in patients suffering from breast cancer (malignant mastopathy) due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Lupus

This medicine should be used with caution due to the increased risk of lupus (systemic and cutaneous). Report any unusual signs and symptoms such as extreme tiredness, painful joints, rashes, lesions on the skin, etc. to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Liver disease

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Vitamin B-12 Deficiency

Long-term treatment with this medicine may decrease the absorption of Vitamin B-12 in the body. Close monitoring of vitamin B12 levels, appropriate supplementation, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Cardiovascular diseases

This medicine should be used with extreme caution in patients with a history of stroke, blood clotting disorders, and other disorders of the heart and blood vessels due to the increased risk of worsening of the patient's condition. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Diabetes

This medicine should be used with caution in patients suffering from diabetes due to the increased risk of altered blood sugar levels. Close monitoring of blood glucose levels is recommended for these patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Changes in electrolyte levels

This medicine should be used with caution due to the increased risk of a change in electrolyte levels (low magnesium levels, low potassium levels, etc.) Close monitoring of electrolyte levels, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Driving or Operating machinery

This medicine may cause symptoms such as moderate-to-severe drowsiness, unusual tiredness or weakness, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Leukopenia

This medicine should be used with caution due to the increased risk of leukopenia (decreased white blood cell count). Report any symptoms such as fever with chills, sore throat, mouth ulcers, etc. to the doctor immediately. Close monitoring of clinical condition, appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Use in elderly

This medicine should be used with caution in the elderly patients due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Menstrual abnormalities

Use of this medicine has been associated with abnormalities in the menstrual cycle. Contact your doctor if the regular periods are excessively delayed. Replacement with a suitable alternative may be necessary in some cases.

Clostridium difficile-associated Diarrhea

Use of this medicine has been associated with Clostridium difficile-associated diarrhea in some cases. This risk is especially higher in patients with a history of gastrointestinal diseases. Report any symptoms such as a severe and persistent diarrhea, abdominal cramps, etc. to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, fainting, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
Interaction with Medicine

Diltiazem

Ketoconazole

Phenytoin

Pregabalin

Sucralfate

Tramadol

Aluminium Hydroxide/Magnesium Hydroxide

Warfarin

Nelfinavir

Digoxin

Ipratropium

Disease interactions

Liver Disease

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Osteoporosis

This medicine should be used with extreme caution in patients with a history of osteoporosis due to the increased risk of osteoporosis-related fractures. Established treatment guidelines should be followed strictly in such patients. Close monitoring of bone mineral density, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Cardiovascular disease

This medicine should be used with caution in patients suffering cardiovascular diseases due to the increased risk of severe adverse effects. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Prolactin imbalance

This medicine is not recommended for use in patients having an abnormal level of the hormone prolactin. Breast cancer due to a high level of prolactin should be ruled out before treatment with this medicine is initiated.

Neuroleptic Malignant Syndrome (NMS)

This medicine is not recommended for use in patients with a history of Neuroleptic malignant syndrome due to the increased risk of recurrent symptoms. If the medicine is used, the patient should be monitored closely for any unusual symptoms such as extreme fever, muscle rigidity, irregular heart rate and blood pressure, excessive sweating, etc. Replacement with a suitable alternative should be considered based on the clinical condition of the patient.

Asthma

This medicine should be used with caution in patients with a history of asthma due to the increased risk of severe adverse effects. Report any symptoms such as difficulty in breathing, wheezing, chest pain, etc. to the doctor immediately. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases.
Food interactions
Information not available.
Lab interactions

Prolactin test

Report the use of this medicine before undergoing a laboratory test to determine the levels of the hormone prolactin in the body. This medicine may interfere with the test and yield false positive results.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take this medicine as advised by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

May cause sleepiness

How it works
Levosulpiride inhibits the action of certain specific chemical substances in the brain as well as at specific sites in the stomach and the intestines. This promotes an early emptying of the stomach. Rabeprazole interferes with the final step of acid release in the stomach. This, in turn, reduces the acidity in the stomach and promotes healing of ulcers.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Atypical antipsychotics, GI stimulants, Proton pump inhibitors

Schedule

Schedule H

Levosulpiride [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 22 August 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/688272#section=Top

Sulpiride - DrugBank [Internet]. Drugbank.ca. 2018 [cited 22 August 2018]. Available from:

https://www.drugbank.ca/drugs/DB00391

DailyMed - Rabeprazole tablet, delayed release [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 22 August 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=951caefe-6e18-48ff-9567-beb545b09c25
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Information on this page was last updated on 22 Aug 2018

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