Regorafenib

Description

Regorafenib is used to treat metastatic colorectal cancer (cancer that starts either in the colon or rectum) in patients who have not adequately responded to other anticancer medications. It is also used to treat tumors of the stomach, intestines, or esophagus and a type of liver cancer called hepatocellular carcinoma.

Side effects

Major & minor side effects for Regorafenib

  • Coughing up blood
  • Dizziness
  • Headache
  • Bleeding gums
  • Nosebleed
  • Hair loss
  • Weight loss
  • Fever or chills
  • Blurred vision
  • Nausea or Vomiting
  • Dry skin
  • Chest pain or discomfort
  • Dark colored urine
  • Weakness
  • Indigestion
  • Diarrhea

Uses of Regorafenib

What is it prescribed for?

  • Colorectal Cancer
  • Gastrointestinal stromal tumor
  • Hepatocellular carcinoma
Read More
Concerns

Commonly asked questions

  • Onset of action
    The amount of time taken by this medicine to show its effect is subject to vary based on the intended use.
  • Duration of effect
    The amount of time for which this medicine remains effective in the body is subject to vary based on the intended use and duration of use.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If this medicine is used, close monitoring of the infant for any undesired side effects is recommended.

Allergy

This medicine is not recommended for use in patients with a known allergy to regorafenib or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If this medicine is used, close monitoring of the infant for any undesired side effects is recommended.
General warnings

Bleeding

Increased risk of bleeding may occur with this medicine. It is advised to discontinue this medicine in case of serious bleeding events.

Hypertension

This medicine should be used with caution due to the increased risk of hypertension (increased blood pressure). Blood pressure should be monitored regularly while receiving this medicine. In cases of severe or persistent hypertension or hypertensive crisis despite institution of antihypertensive therapy, permanent discontinuation of Regorafenib should be considered.

Heart diseases

This medicine should be used with caution in patients with heart diseases due to the increased risk of adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Dermatological toxicity

Hand-foot skin reaction and rash represent the most common adverse drug reactions with this medicine during treatment. Management of dermatological toxicities may include topical therapies for symptomatic relief, temporary treatment discontinuation and/or dose modification, or in severe or persistent cases, permanent discontinuation of the treatment.

Risk of infections

Use of this medicine may weaken the immune system and may make you more vulnerable to infections. It is advised that you avoid coming in contact with people suffering from an infection while taking this medicine.

Driving or operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Use in children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Do not double your dose to make up for the missed dose. Contact your doctor for further instructions if you miss more than one scheduled dose of this medicine.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Leflunomide

Efavirenz

Rosuvastatin

Clarithromycin

Warfarin

Diclofenac

Aspirin

Disease interactions

Lung Toxicity

This medicine should be used with caution in patients with a history of interstitial lung disease presenting with acute onset of new or progressive unexplained pulmonary symptoms such as dyspnea, cough, and fever pending diagnostic evaluation due to the increased risk of the lung toxicity. Appropriate dose adjustments and frequent clinical monitoring are advised in such cases. Replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Consumption of grapefruit or grapefruit juice is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
Lab interactions
Information not available.
Take this medicine with food exactly as instructed by the doctor. Do not take in larger or smaller amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by inhibiting the actions of certain proteins that cause the cancer cells to multiply. This helps in stopping the growth and spread of cancer.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Multikinase inhibitors, VEGF/VEGFR inhibitors

Schedule

Schedule H

[Internet]. Drugbank.ca. 2018 [cited 13 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB08896

[Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 13 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Regorafenib

[Internet]. Medlineplus.gov. 2018 [cited 13 December 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a613004.html

[Internet]. Accessdata.fda.gov. 2018 [cited 13 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203085lbl.pdf

How will this medicine affect me?

Consult top doctors online and get an answer now
Chat now

Looking for a doctor?

Book an appointment with the top doctors near you
Book now
Something doesn’t feel right?
Report an error

Information on this page was last updated on 10 May 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.