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Razel-EZ Tablet

Manufactured byGLENMARK PHARMACEUTICALS LTD
ContainsRosuvastatin (10 mg) + Ezetimibe (10 mg)
Description

Razel-EZ Tablet is a combination medicine used for the treatment of primary hypercholesterolemia, a condition characterized by high levels of cholesterol in the blood. Patients are advised to maintain a strict exercise and diet regimen along with this medicine to get the best possible effect.

Side effects

Major & minor side effects for Razel-EZ Tablet

  • Muscle pain
  • Tenderness
  • Weakness
  • Headache
  • Joint pain
  • Acid or sour stomach
  • Diarrhea
  • Excessive air or gas in stomach
  • Blood in urine
  • Redness of the skin especially on the face and neck
  • Dizziness
  • Sore throat
  • Runny Nose
  • Sneezing
  • Itching
  • Loss of appetite
  • Fever
  • Cough

Uses of Razel-EZ Tablet

What is it prescribed for?

  • Primary Hypercholesterolemia
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 3 to 5 hours of administration of the dose.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit forming tendency has been reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women. Your doctor may prescribe a safer alternative based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to rosuvastatin, ezetimibe, or any other inactive ingredients present along with these medicines.

Active liver disease

This medicine is not recommended for use in patients with active liver diseases or any abnormality in the liver function tests due to the increased risk of severe adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women. Your doctor may prescribe a safer alternative based on your clinical condition.
General warnings

Cognitive impairment

This medicine may cause forgetfulness, memory loss, confusion, etc. in some patients. These side effects are reversible and usually disappear once the medicine is discontinued.

Altered blood sugar levels

This medicine may cause an alteration in the blood sugar levels. This risk is especially higher in patients with diabetes mellitus. Close monitoring of blood sugar levels may be necessary based on the clinical condition. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.

Myopathy and Rhabdomyolysis

This medicine may cause muscle breakdown and rhabdomyolysis in some patients, a condition which can be fatal. This may cause symptoms such as severe tiredness and weakness. This risk is especially higher in the elderly population and in patients with active muscle disorders. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Alcohol consumption

This medicine may cause liver and kidney injuries in patients consuming alcohol very frequently and in large quantities. Hence, consumption of alcohol should be avoided during treatment with this medicine.

Use in pediatrics

This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.

Coumarin Anticoagulants

This medicine should be used with caution in patients receiving coumarin anticoagulants such as warfarin due to the increased risk of excessive bleeding. Close monitoring of International Normalized Ratio (INR) is recommended for such patients. Appropriate dose adjustments may be required based on the clinical condition.

Pregnancy

This medicine is not recommended for use in pregnant women due to the increased risk of fetal harm.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Leflunomide

Atazanavir

Cyclosporine

Colchicine

Gemfibrozil

Cholestyramine

Fenofibrate

Disease interactions

Diabetes

This medicine should be used with caution in patients with diabetes mellitus due to the increased risk of altered blood sugar levels. Close monitoring of blood sugar levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Rhabdomyolysis

This medicine is not recommended for use in patients with rhabdomyolysis due to the increased risk of renal failure and death. Replacement with a suitable alternative should be considered under your doctor's supervision.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as advised by your doctor. It can be taken with or without food. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Rosuvastatin reduces the production of cholesterol from the liver. Ezetimibe works by reducing or stopping the absorption of cholesterol through the small intestine. Their combination is thus better effective than monotherapy in the treatment of primary hypercholesterolemia.
Legal Status

Approved

Unknown

Unknown

Approved

Classification

Category

Statins, Cholesterol absorption inhibitors, Antihyperlipidemic combinations

Schedule

Schedule H

DailyMed - Rosuvastatin calcium tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 24 February 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=134c5455-5171-66f3-e0c4-c475978ffb22

Rosuvastatin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 24 February 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a603033.html

[Internet]. 2017 [cited 24 February 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/11976

Ezetimibe tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 23 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f26e7a4e-b3d9-4cf8-baf0-7423d46cd8ba

Ezetimibe: DrugBank [Internet]. Drugbank.ca. 2017 [cited 23 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB00973

Ezetimibe: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 23 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a603015.html

Rosuzet Composite Pack (ezetimibe and rosuvastatin calcium) Drug / Medicine Information [Internet]. News-Medical.net. 2017 [cited 26 December 2017]. Available from:

https://www.news-medical.net/drugs/Rosuzet-Composite-Pack.aspx
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Information on this page was last updated on 16 May 2018

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