Rasburicase

Description

Rasburicase is used to treat the increased uric acid levels (hyperuricemia) in patients during cancer treatments. This medicine helps to lower uric acid levels in patients receiving chemotherapy expected to get an elevation of uric acid levels in the blood.

Side effects

Major & minor side effects for Rasburicase

  • Cracked lips
  • Difficulty in swallowing
  • Ulcer, sores, or white spots in the mouth
  • Stomach pain
  • Changes in color of skin
  • Changes in vision
  • Chills
  • Cough
  • Dizziness
  • Dry mouth
  • Increased sweating
  • Lower back or side pain
  • Nausea
  • Skin Rash
  • Vomiting
  • Itching

Uses of Rasburicase

What is it prescribed for?

  • Hyperuricemia Secondary to Chemotherapy
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 4 hours of administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use if you have a known allergy to Rasburicase or any other active ingredients present along with it.

G6PD deficiency

This medicine is not recommended for use in patients with G6PD deficiency due to the increased risk of worsening of the patient's condition.

Hemolysis or Methemoglobinemia

This medicine is not recommended for use in patients with a history of hemolysis (breakdown of red blood cells) or methemoglobinemia (a condition that affects the oxygen-carrying capacity of red blood cells) reactions to rasburicase due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Methemoglobinemia

Use of this medicine may lead to a condition that affects the oxygen-carrying capacity of red blood cells (methemoglobinemia) in some patients. Replacement with a suitable alternative may be necessary for such patients based on the clinical condition.

Anaphylactic reactions

This medicine may cause severe allergic reactions or anaphylaxis including anaphylactic shock in some patients. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Hydration

Drink adequate amount of water (2 liters/day) for adequate hydration as part of uric acid management

Hemolysis

Use of this medicine may lead to hemolysis (breakdown of red blood cells) in some patients. Replacement with a suitable alternative may be necessary for such patients based on the clinical condition.

Uric acid levels

This medicine may lower the uric acid levels to below normal levels in some patients. Close monitoring of blood uric acid levels is necessary while receiving this medicine.

Missed Dose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Sodium Nitrite

Prilocaine

Idelalisib

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Effect on sleep is not established

How it works
It works by reducing the uric acid levels in the body.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antihyperuricemic agents

Schedule

Schedule H

Rasburicase - DrugBank [Internet]. Drugbank.ca. 2018 [cited 24 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB00049

[Internet]. Medicines.org.uk. 2018 [cited 24 December 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.1316.pdf

[Internet]. Ec.europa.eu. 2018 [cited 24 December 2018]. Available from:

https://ec.europa.eu/health/documents/community-register/2013/20131120127263/anx_127263_en.pdf

[Internet]. Products.sanofi.ca. 2018 [cited 24 December 2018]. Available from:

http://products.sanofi.ca/en/fasturtec.pdf

[Internet]. Accessdata.fda.gov. 2018 [cited 24 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/rasbsan071202LB.pdf

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Information on this page was last updated on 13 Feb 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.