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Rasagiline

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Description

Rasagiline is used either alone or in combination with other medicines to treat the symptoms of Parkinson's disease such as shakiness, stiffness, difficulty with movements, etc. The recommended dose of this medicine should not be exceeded due to the increased risk of hypertension.

Side effects

Major & minor side effects for Rasagiline

  • Hypersensitivitysevererare
  • Increase in blood pressuresevere
  • Sleepiness or unusual drowsinesssevere
  • Orthostatic Hypotensionsevere
  • Dyskinesiasevere
  • Serotonin syndromesevererare
  • Nausea
SEVERE
Contact your doctor immediately if any of these symptoms are experienced on a regular basis.
RARE
Observed in a small fraction of population.
This is not an exhaustive list of side effects. Please inform your doctor if you experience any adverse reaction to the medication.

Highlights

Commonly asked questions for Rasagiline

Onset of action

The effect of this medicine can be observed within 1 hour of administration of the dose.

Duration of effect

The amount of time for which this medicine remains active in the body is not clinically established.

Safe with alcohol?

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Is it habit forming?

No habit forming tendencies were reported.

Usage in pregnancy?

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Usage while breast-feeding?

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

What is it prescribed for?

Uses of Rasagiline

  • Parkinson's disease

    Rasagiline is used either alone or in combination with other drugs to control the symptoms of Parkinson's disease such as shakiness, muscle stiffness, loss of normal movements, and switching between normal movements and stiffness.

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When not to use?

Contraindications of Rasagiline

  • Allergy

    This medicine is not recommended for use in patients with a known allergy to rasagiline or any other components present along with it.

Dosage

  • Missed Dose

    If a dose of Rasagiline is missed, take the missed dose as soon as you remember it. If it is almost time for the next dose, continue with the normal dosing schedule. Do not double your dose to make up for the missed one.

  • Overdose

    Seek emergency medical treatment or contact a doctor immediately in case of an overdose. Symptoms of an overdose may include drowsiness, dizziness, fainting, a severe headache, etc.

Interactions

All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.

Interaction with Alcohol

  • Description

    - Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

  • Instructions

    - Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Interaction with Medicine

  • Linezolidsevere
  • Tapentadolsevere
  • Antidepressantssevere
  • 5-Hydroxytryptophansevere
  • Anaestheticssevere

Disease interactions

  • Hypotension

    severe
    This medicine should be used with caution due to an increased risk of a very low blood pressure while getting up from a lying or a sitting position. This risk is especially higher in patients receiving high blood pressure medicines. Close monitoring of blood pressure in necessary while receiving this medicine. Report any symptoms of hypotension such as lightheadedness or fainting to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

  • Psychotic disorders

    severe
    This medicine is not recommended for use in patients with psychotic disorders due to the increased risk of worsening of the patient's condition.

  • Hepatic impairment

    severe
    Rasagiline is not recommended for use in patients with moderate to severe hepatic impairment. Appropriate dose adjustments should be done in patients with mild hepatic impairment to avoid undesired side effects.

  • Hypertension

    moderate
    Rasagiline may cause a sudden increase in the blood pressure. Close monitoring of blood pressure is necessary while receiving this medicine. Appropriate dose adjustments may be required if the elevation in blood pressure is persistent. Patients should be screened for new onset hypertension or uncontrolled hypertension before initiating therapy with this medicine.

Food interactions

  • Use of caffeine along with Rasagiline may cause alterations in blood pressure, dizziness, confusion, nausea, vomiting, and hallucinations. It is advised that you do not consume caffeine during treatment with this medicine.
  • Using Rasagiline along with foods rich in tyramine such as aged or processed cheese, red wine, bananas, avocados, yogurt, etc. may cause a sudden increase in the blood pressure. Report any symptoms such as a sudden, severe headache; difficulty thinking; seizures; or chest pain; etc. to the doctor immediately. Your dietitian/doctor may suggest appropriate changes in your diet based on your clinical condition.

Lab interactions

  • Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

General Instructions

Take Rasagiline as instructed by the doctor. Do not take this medicine in larger or smaller quantities than prescribed. Do not stop the use of this medicine without consulting your doctor. Close monitoring of kidney function and blood pressure is necessary while receiving this medicine.

Warnings

Warnings for special population

  • Pregnancy

    - This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

  • Breast-feeding

    - This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

General warnings

  • Orthostatic hypotension

    - Rasagiline may cause hypotension (low blood pressure) and fainting while suddenly getting up from a sitting or a lying position. Patients should get up slowly to avoid these side effects. Report any symptoms such as dizziness, fainting, weakness, etc. to the doctor immediately. Appropriate dose adjustments may be necessary based on the clinical condition.

  • Hyperpyrexia and confusion

    - This medicine may cause an increase in body temperature, altered consciousness, and muscular rigidity associated with withdrawal or dose reduction or dose change. Close monitoring and appropriate corrective measures may be required based on the clinical condition.

  • Use in pediatrics

    - Use of this medicine in children and adolescents is not recommended.

  • Drowsiness

    - Rasagiline may cause dizziness or drowsiness. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery while receiving this medicine.

  • Other Medicines

    - Rasagiline may interact with many other medicines and may cause severe side effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Other details

  • Can be taken with or without food, as advised by your doctor
  • To be taken as instructed by doctor
  • May cause sleepiness

How it works

Rasagiline works by blocking the breakdown of and increasing the amount of dopamine, a natural substance present in the brain which is needed to control movements of the body. This helps in slowing down the symptoms of Parkinson's.

Legal Status

Approved
Approved
Approved
Approved

Classification

Category
Monoamine oxidase type B inhibitors (MAOBI)
Schedule
N/A

References

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Information on this page was last updated on 6 Sep 2017

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Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.