Rasagiline

Description

Rasagiline is used either alone or in combination with other medicines to treat the symptoms of Parkinson's disease such as shakiness, stiffness, difficulty with movements, etc. The recommended dose of this medicine should not be exceeded due to the increased risk of hypertension.

Side effects

Major & minor side effects for Rasagiline

  • Hypersensitivity
  • Increase in blood pressure
  • Sleepiness or unusual drowsiness
  • Orthostatic Hypotension
  • Dyskinesia
  • Serotonin syndrome
  • Nausea

Uses of Rasagiline

What is it prescribed for?

  • Parkinson's disease
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 1 hour of administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to rasagiline or any other components present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Orthostatic hypotension

Rasagiline may cause hypotension (low blood pressure) and fainting while suddenly getting up from a sitting or a lying position. Patients should get up slowly to avoid these side effects. Report any symptoms such as dizziness, fainting, weakness, etc. to the doctor immediately. Appropriate dose adjustments may be necessary based on the clinical condition.

Hyperpyrexia and confusion

This medicine may cause an increase in body temperature, altered consciousness, and muscular rigidity associated with withdrawal or dose reduction or dose change. Close monitoring and appropriate corrective measures may be required based on the clinical condition.

Use in pediatrics

Use of this medicine in children and adolescents is not recommended.

Drowsiness

Rasagiline may cause dizziness or drowsiness. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery while receiving this medicine.

Other Medicines

Rasagiline may interact with many other medicines and may cause severe side effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Missed Dose

If a dose of Rasagiline is missed, take the missed dose as soon as you remember it. If it is almost time for the next dose, continue with the normal dosing schedule. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact a doctor immediately in case of an overdose. Symptoms of an overdose may include drowsiness, dizziness, fainting, a severe headache, etc.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Linezolid

Tapentadol

Antidepressants

5-Hydroxytryptophan

Anaesthetics

Disease interactions

Hypotension

This medicine should be used with caution due to an increased risk of a very low blood pressure while getting up from a lying or a sitting position. This risk is especially higher in patients receiving high blood pressure medicines. Close monitoring of blood pressure in necessary while receiving this medicine. Report any symptoms of hypotension such as lightheadedness or fainting to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Psychotic disorders

This medicine is not recommended for use in patients with psychotic disorders due to the increased risk of worsening of the patient's condition.

Hepatic impairment

Rasagiline is not recommended for use in patients with moderate to severe hepatic impairment. Appropriate dose adjustments should be done in patients with mild hepatic impairment to avoid undesired side effects.

Hypertension

Rasagiline may cause a sudden increase in the blood pressure. Close monitoring of blood pressure is necessary while receiving this medicine. Appropriate dose adjustments may be required if the elevation in blood pressure is persistent. Patients should be screened for new onset hypertension or uncontrolled hypertension before initiating therapy with this medicine.
Food interactions
Use of caffeine along with Rasagiline may cause alterations in blood pressure, dizziness, confusion, nausea, vomiting, and hallucinations. It is advised that you do not consume caffeine during treatment with this medicine.
Using Rasagiline along with foods rich in tyramine such as aged or processed cheese, red wine, bananas, avocados, yogurt, etc. may cause a sudden increase in the blood pressure. Report any symptoms such as a sudden, severe headache; difficulty thinking; seizures; or chest pain; etc. to the doctor immediately. Your dietitian/doctor may suggest appropriate changes in your diet based on your clinical condition.
Lab interactions
Information not available.
Take Rasagiline as instructed by the doctor. Do not take this medicine in larger or smaller quantities than prescribed. Do not stop the use of this medicine without consulting your doctor. Close monitoring of kidney function and blood pressure is necessary while receiving this medicine.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Rasagiline works by blocking the breakdown of and increasing the amount of dopamine, a natural substance present in the brain which is needed to control movements of the body. This helps in slowing down the symptoms of Parkinson's.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Monoamine oxidase type B inhibitors (MAOBI)

Schedule

N/A

Rasagiline: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 22 August 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a606017.html

DailyMed - RASAGILINE MESYLATE- rasagiline mesylate tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 22 August 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=212ec349-2fbb-43dc-9dd1-745efddb52fa&audience=consumer

[Internet]. 2017 [cited 22 August 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.31278.latest.pdf

Rasagiline - DrugBank [Internet]. Drugbank.ca. 2017 [cited 22 August 2017]. Available from:

https://www.drugbank.ca/drugs/DB01367

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 22 August 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database

Rasagiline (substance) [Internet]. Snomedbrowser.com. 2017 [cited 22 August 2017]. Available from:

http://www.snomedbrowser.com/Codes/Details/418734001

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Information on this page was last updated on 6 Sep 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.