Ranolazine

Description

Ranolazine is used to relieve chest pain in conditions like chronic angina. Proper lifestyle modifications are necessary along with this medicine for a speedy recovery. Elderly and low body weight patients should use this medicine with caution due to the increased risk of undesired effects.

Side effects

Major & minor side effects for Ranolazine

  • Dizziness
  • Ringing or buzzing in the ears
  • Chest tightness
  • Headache
  • Blurred vision
  • Constipation
  • Dry mouth
  • Stomach pain
  • Loss of strength

Uses of Ranolazine

What is it prescribed for?

  • Angina Pectoris
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time needed for this medicine to show its effect is not clinically established. However, it takes 2 to 6 hours to reach maximum concentration in the blood.
  • Duration of effect
    This medicine remains active in the body for an average duration of 21 hours after an oral dose.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Liver disease

This medicine is not recommended for use in patients with a severe liver disease.

Drug interaction

This medicine is not recommended for use in patients receiving strong CYP3A inhibitors like ketoconazole, clarithromycin, nelfinavir and CYP3A inducers like carbamazepine, phenobarbital, phenytoin, rifampin, etc. due to alteration in Ranolazine blood levels.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Elderly population

Ranolazine should be used with caution in patients more than 60 years of age due to an increase in the risk of undesired effects. Close monitoring of kidney function is necessary. The dose should be adjusted based on the kidney function.

Low body weight

Ranolazine should be used with caution in patients less than 60 kg of body weight due to an increase in the risk of undesired effects. The dose should be adjusted based on the body weight.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already the time for your next scheduled dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Metformin

Phenytoin

Digoxin

Atorvastatin

Disease interactions

Liver Disease

Ranolazine is not recommended for use in patients with a history of liver disease or active liver disease due to an increase in the risk of serious adverse effects. An alternate treatment option should be considered based on the clinical condition.

Kidney disease

Ranolazine should be used with caution in patients with a history of kidney disease or active kidney disease due to an increase in the risk of serious adverse effects. An alternate treatment option should be considered based on the clinical condition.

QT Prolongation

This medicine should be used with caution in patients with a history of prolonged QT interval and patients using medicines that prolong QT interval. Appropriate dose adjustments should be made under your doctor's supervision.
Food interactions
Consumption of grapefruit juice while taking Ranolazine is not recommended due to an increase in the risk of dizziness, fast heartbeat, and fainting. Any such symptoms should be reported to the doctor on priority.
Lab interactions
Information not available.
Take Ranolazine as advised by the doctor. Do not consume larger quantities than prescribed. It is advised that you inform the doctor if you have a history of liver or kidney disease. Proper lifestyle modifications should be adopted along with the medicine to prevent further complications. Report to the doctor if you experience any undesired effects while receiving the medicine.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It works by relaxing the heart muscles and thus relieves the chest pain.
Legal Status

Approved

Approved

Approved

Unknown

Classification

Category

Antianginal agents

Schedule

Schedule H

[Internet]. 2017 [cited 14 July 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/21402

DailyMed - Ranolazine tablet, film coated, extended release [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 14 July 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8d442b8c-97a8-40a9-8603-f9cd0542cedc

[Internet]. Gilead.com. 2018 [cited 5 January 2018]. Available from:

http://www.gilead.com/~/media/Files/pdfs/medicines/cardiovascular/ranexa/ranexa_pi.ashx

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Information on this page was last updated on 5 Jan 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.