Rafle 400 MG Tablet ER

Manufactured byAlembic Ltd.
ContainsRifaximin
Description

Rafle 400 MG Tablet ER is an effective medicine used to treat bacterial infections of the intestine. It is used for the treatment of traveler's diarrhea, irritable bowel syndrome with diarrhea caused due to certain specific strains of bacteria.

Substitutes

List of substitutes for Rafle 400 MG Tablet ER

Side effects

Major & minor side effects for Rafle 400 MG Tablet ER

  • Black or Tarry stools
  • Difficult and painful breathing
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Watery and bloody diarrhea with stomach cramps and fever
  • Nausea and Vomiting
  • Headache
  • Blood in urine
  • Unusual bleeding or bruising
  • Ulcer and sore throat
  • Ringing or buzzing in the ears
  • Flatulence
  • Muscle and joint pain
  • Blurred vision
  • Mental Confusion
  • Dry mouth and lips
  • Dizziness and fainting
  • Unusual tiredness and weakness

Uses of Rafle 400 MG Tablet ER

What is it prescribed for?

  • Traveler's Diarrhea
  • Hepatic encephalopathy
  • Irritable bowel syndrome associated diarrhea
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Concerns

Commonly asked questions

  • Onset of action
    The time taken for this medicine to show its initial effect is not established. It takes about an hour to achieve the peak concentration in the body upon oral administration.
  • Duration of effect
    The time duration for which this medicine remains effective in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    Use of this medicine during pregnancy is not recommended unless absolutely necessary and the benefits outweigh the risks involved. Consult your doctor before taking this medicine.
  • Usage while breast-feeding?
    Use of this medicine by breastfeeding women is not recommended. However, if it becomes necessary to use this medicine then breastfeeding should be discontinued. Consult your doctor before using this medicine.

Allergy

This medicine is not recommended for use if you have a known history of allergy to rifaximin or any other ingredient present with it.
Warnings for special population

Pregnancy

Use of this medicine during pregnancy is not recommended unless absolutely necessary and the benefits outweigh the risks involved. Consult your doctor before taking this medicine.

Breast-feeding

Use of this medicine by breastfeeding women is not recommended. However, if it becomes necessary to use this medicine then breastfeeding should be discontinued. Consult your doctor before using this medicine.
General warnings

Traveler's diarrhea caused by other bacteria

This medicine is not effective to treat diarrhea which is caused by other organisms like Campylobacter jejuni or shigella strains. Any diarrhea complicated by fever and/or blood in the stool should not be treated with this medicine.

Clostridium difficile-associated diarrhea

The use of this medicine can cause clostridium difficile-associated diarrhea by killing the gut friendly microorganisms. This results in the production of toxins in the gut which may lead to further diarrhea or a severe colitis.

Drug resistance

It is advised to take this medicine for the entire course. Failure to do so will result in drug-resistant bacteria and subsequent infections will not be treatable by the same medicine.

Liver impairment

This medicine should be used with caution in patients having moderate to severe impairment of liver function.

Dizziness

Use of this medicine may cause dizziness in some patients. Do not drive or operate heavy machinery after taking this medicine till you are sure about the effect of this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose then the missed dose can be skipped.

Overdose

Contact your doctor immediately if an overdose with this medicine is suspected. Symptoms of an overdose may include fainting, difficulty in breathing, dizziness, headache, nausea and vomiting.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Ketoconazole

Pantoprazole

Propranolol

Warfarin

Cyclosporine

Live cholera vaccine

Disease interactions

Colitis

This medicine should be used with caution in patients having colitis or other diseases of the gastrointestinal tract as the risk of worsening of the disease is significantly high. The use of this medicine should be stopped if the patient experiences diarrhea for prolonged duration of time.

Liver Disease

This medicine should be administered with caution in patients having an impairment of liver function.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Rafle 400 MG Tablet ER as instructed by the doctor. It is advised to take this medicine for the entire prescribed duration even when the symptoms have resolved. This medicine can be taken with or without food. An adequate amount of water should be consumed while and after taking this medicine.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by interfering with some vital processes in the bacterial cell and stopping the growth and multiplication of the microorganism.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Miscellaneous antibiotics

Schedule

Schedule H

[Internet]. 2017 [cited 3 May 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/27427

[Internet]. 2017 [cited 3 May 2017]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021361s013lbl.pdf

DailyMed - rifaximin tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 3 May 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c5e8e2fd-7087-4b78-9181-cc259c0be2f1

Rifaximin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 3 May 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a604027.html
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