Prucalopride

Description

Prucalopride is used for the treatment of chronic idiopathic constipation in adults patients who failed to respond with laxative therapy. This medicine is not recommended for use in patients below 18 years of age.

Side effects

Major & minor side effects for Prucalopride

  • Headache
  • Vomiting
  • Decreased appetite
  • Dizziness
  • Tiredness
  • Abdominal pain
  • Fever
  • Diarrhea

Uses of Prucalopride

What is it prescribed for?

  • Chronic Idiopathic Constipation
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Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine can be observed within 2-3 hours of administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No-habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to prucalopride or any other inactive ingredients present along with it.

Intestinal Obstruction

This medicine is not recommended for use in patients suffering from intestinal obstruction or severe inflammatory conditions of the intestinal tract such as Crohn's disease and Ulcerative colitis due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of adverse effects. Close monitoring of kidney function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Liver Disease

This medicine should be used with caution in patients with severe liver diseases due to the increased risk of severe side effects. Regular monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Serious medical problems

This medicine should only be used under the supervision of healthcare professional in patients with serious comorbid conditions such as lung disease, cancer, hormonal disorder, nervous system or mental health problems due to the increased risk of severe adverse effects.

Use in Children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Contraception

Use of this medicine reported severe diarrhea in some patients which may make contraceptive pills to not work properly. This may result in an unwanted pregnancy. Effective contraception is advised for the women with the childbearing potential to avoid such risks.

Driving or operating machines

Use of this medicine may cause symptoms such as dizziness, drowsiness, blurred vision, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Albendazole

Erythromycin

Amiodarone

Atorvastatin

Ketoconazole

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with or without food. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking the medicine before completion of the course/without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine acts by increasing the concentration of a certain chemical at the nerve endings causing an increase in stomach muscle movement. This helps in the faster movement of food from the stomach to the intestine.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Prokinetic agent

Schedule

Schedule H

[Internet]. Ema.europa.eu. 2018 [cited 20 September 2018]. Available from:

http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/001012/WC500053998.pdf

[Internet]. Janssen.com. 2018 [cited 20 September 2018]. Available from:

https://www.janssen.com/canada/sites/www_janssen_com_canada/files/prod_files/live/resotran_cpm.pdf

Prucalopride - DrugBank [Internet]. Drugbank.ca. 2018 [cited 20 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB06480

[Internet]. Medicines.org.uk. 2018 [cited 20 September 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.586.pdf

Prucalopride [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 20 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Prucalopride

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Information on this page was last updated on 6 Feb 2019

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