Prothionamide
Description
Prothionamide is an antimycobacterial medicine used to treat tuberculosis. It is generally used in patients who have acquired resistance to other anti-tubercular medicines. It is usually taken in a combination with other medicines to treat all types of Mycobacterium tuberculosis.
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Side effects
Major & minor side effects for Prothionamide
- Nausea and Vomiting
- Stomach pain
- Diarrhoea
- Dizziness
- Headache
- Skin Rash
- Double vision
- Loss of appetite
- Confusion
Uses of Prothionamide
What is it prescribed for?
- Tuberculosis
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Concerns
Commonly asked questions
- Onset of actionThe amount of time required for this medicine to show its action is not clinically established.
- Duration of effectThe amount of time for which this medicine remains active in the body is not clinically established.
- Safe with alcohol?Consumption of alcohol during treatment with this medicine may increase the risk of severe side effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
- Is it habit forming?No habit-forming tendencies were reported.
- Usage in pregnancy?This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
- Usage while breast-feeding?This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the medicine or to discontinue breastfeeding based on your clinical condition.
Allergy
This medicine is not recommended for use in patients with a known allergy to prothionamide or any other inactive ingredients present along with it.
Severe Hepatic impairment
This medicine is not recommended for use in patients with severe liver impairment due to the increased risk of worsening of the patient's condition.
Seizures
This medicine is not recommended for use in patients suffering from seizures due to the increased risk of worsening of the patient's condition.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the medicine or to discontinue breastfeeding based on your clinical condition.
General warnings
Driving or Operating machinery
This medicine may cause dizziness or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
Liver function impairment
This medicine should be used with extreme caution in patients suffering from mild to moderate liver diseases or patients at risk of liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition. This medicine is not recommended for use in patients with severe liver diseases.
Kidney function Impairment
This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Drug resistance
Usage of this medicine without sufficient proof or suspicion of a mycobacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.
Missed Dose
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.
Overdose
Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
N/A
Instructions
Consumption of alcohol during treatment with this medicine may increase the risk of severe side effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
Interaction with Medicine
BCG vaccine
Rifampicin
Cycloserine
Picosulfuric acid
Disease interactions
Diabetes Mellitus
This medicine should be used with caution in patients with diabetes mellitus since it may alter the blood glucose levels. Close monitoring of blood glucose levels, appropriate patient education, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.
Liver Disease
This medicine is not recommended for use in patients with severe liver diseases or a known history of liver injury due to the use of this medicine. In patients with mild to moderate liver diseases, close monitoring of liver function tests is recommended. Appropriate dose adjustments or replacement with a suitable alternative may be necessary for these patients based on their clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with or without food, as directed by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Complete the course of treatment to prevent the spread of the infection. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous
How it works
It interferes with the cell wall synthesis and stops the growth of bacteria.
Legal Status
Classification
Category
Antituberculosis agents
Schedule
Schedule H
[Internet]. Vardgivarwebb.regionostergotland.se. 2018 [cited 14 September 2018]. Available from:
[Internet]. Tbdrugmonographs.co.uk. 2018 [cited 14 September 2018]. Available from:
Protionamide [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 14 September 2018]. Available from:
Protionamide - DrugBank [Internet]. Drugbank.ca. 2018 [cited 14 September 2018]. Available from:
Prothionamide [Internet]. TB Drug Monographs. 2018 [cited 14 September 2018]. Available from:
Information on this page was last updated on 11 Jan 2019
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.