Prothionamide

Description

Prothionamide is an antimycobacterial medicine used to treat tuberculosis. It is generally used in patients who have acquired resistance to other anti-tubercular medicines. It is usually taken in a combination with other medicines to treat all types of Mycobacterium tuberculosis.

Side effects

Major & minor side effects for Prothionamide

  • Nausea and Vomiting
  • Stomach pain
  • Diarrhoea
  • Dizziness
  • Headache
  • Skin Rash
  • Double vision
  • Loss of appetite
  • Confusion

Uses of Prothionamide

What is it prescribed for?

  • Tuberculosis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol during treatment with this medicine may increase the risk of severe side effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the medicine or to discontinue breastfeeding based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to prothionamide or any other inactive ingredients present along with it.

Severe Hepatic impairment

This medicine is not recommended for use in patients with severe liver impairment due to the increased risk of worsening of the patient's condition.

Seizures

This medicine is not recommended for use in patients suffering from seizures due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the medicine or to discontinue breastfeeding based on your clinical condition.
General warnings

Driving or Operating machinery

This medicine may cause dizziness or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Liver function impairment

This medicine should be used with extreme caution in patients suffering from mild to moderate liver diseases or patients at risk of liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition. This medicine is not recommended for use in patients with severe liver diseases.

Kidney function Impairment

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Drug resistance

Usage of this medicine without sufficient proof or suspicion of a mycobacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol during treatment with this medicine may increase the risk of severe side effects. These side effects may include confusion, dizziness, nausea, vomiting, weakness, and fainting. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol while taking this medicine.
Interaction with Medicine

BCG vaccine

Rifampicin

Cycloserine

Picosulfuric acid

Disease interactions

Diabetes Mellitus

This medicine should be used with caution in patients with diabetes mellitus since it may alter the blood glucose levels. Close monitoring of blood glucose levels, appropriate patient education, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Liver Disease

This medicine is not recommended for use in patients with severe liver diseases or a known history of liver injury due to the use of this medicine. In patients with mild to moderate liver diseases, close monitoring of liver function tests is recommended. Appropriate dose adjustments or replacement with a suitable alternative may be necessary for these patients based on their clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine with or without food, as directed by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Complete the course of treatment to prevent the spread of the infection. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
It interferes with the cell wall synthesis and stops the growth of bacteria.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antituberculosis agents

Schedule

Schedule H

[Internet]. Vardgivarwebb.regionostergotland.se. 2018 [cited 14 September 2018]. Available from:

https://vardgivarwebb.regionostergotland.se/pages/233476/Peteha%202008.pdf

[Internet]. Tbdrugmonographs.co.uk. 2018 [cited 14 September 2018]. Available from:

http://www.tbdrugmonographs.co.uk/uploads/2/8/9/4/28941471/mdrtb_adr_monitoring_guidancefinal.pdf

Protionamide [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 14 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Protionamide

Protionamide - DrugBank [Internet]. Drugbank.ca. 2018 [cited 14 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB12667

Prothionamide [Internet]. TB Drug Monographs. 2018 [cited 14 September 2018]. Available from:

http://www.tbdrugmonographs.co.uk/prothionamide.html

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Information on this page was last updated on 11 Jan 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.