Prothiaden M 50 Tablet

Manufactured byABBOTT HEALTHCARE PVT. LTD
ContainsDosulepin (50 mg) + Methylcobalamin (1500 mcg)
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Description

Prothiaden M 50 Tablet is a combination medicine used for the treatment of neuropathic pain, a shooting or burning pain caused by damage or injury to the nerves.

Substitutes

List of substitutes for Prothiaden M 50 Tablet

Side effects

Major & minor side effects for Prothiaden M 50 Tablet

  • Nausea and vomiting
  • Diarrhea
  • Decreased appetite
  • Dizziness
  • Headache
  • Skin rash
  • Chest pain and discomfort
  • Drowsiness
  • Change in heart rate
  • Increase/decrease in libido
  • Constipation
  • Loss of vision or blurred vision
  • Dry mouth
  • Excessive sweating
  • Slurred speech
  • Difficulty with passing urine
  • Burning, numbness, tingling in the arms and feet
  • Mental Confusion

Uses of Prothiaden M 50 Tablet

What is it prescribed for?

  • Neuropathic pain
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious adverse effects such as drowsiness, confusion, impaired judgment, etc. It is advised that you do not perform any activities such as driving a vehicle or operating heavy machinery if you consume alcohol during treatment with this medicine.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, the infant should be monitored closely for any undesired side effects. Alternatively, your doctor may prescribe a safer alternative based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to methylcobalamin, dosulepin, or any other inactive ingredients present along with these medicines.

Monoamine oxidase inhibitors (MAOI)

This medicine is not recommended for use while you are taking any medicine belonging to the monoamine oxidase inhibitors (MAOI) drug class due to an increase in the risk of seizures, fever, hallucinations, and rarely death. Some of the most commonly used medicines in this class are selegiline, isocarboxazid, phenelzine, etc. The time gap between the consumption of these medicines should be a minimum of 14 days.

Heart Attack

This medicine is not recommended for use if you are recovering from a heart attack suffered in the recent times.

Manic phase of bipolar disorder

This medicine is not recommended for use while a patient is experiencing manic episodes of bipolar disorder.

Liver disease

This medicine is not recommended for use in patients having an impairment of the normal liver function.

Leber's Disease

This medicine is not recommended for use in patients suffering from Leber's disease, a rare genetic disorder.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, the infant should be monitored closely for any undesired side effects. Alternatively, your doctor may prescribe a safer alternative based on your clinical condition.
General warnings

Elderly patients

This medicine should be used with caution in the elderly patients due to the increased risk of severe adverse effects. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Other medicines

Many medicines interact with this medicine and may alter the absorption as well as the effects of this medicine. Hence, it is advised that you report to the doctor all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Gastrointestinal surgery

Patients who have had a recent gastrointestinal surgery may have reduced absorption of this medicine. Appropriate dose adjustments should be done under your doctor's supervision.

Use of antacids

Coadministration of antacids and this medicine may reduce the absorption of this medicine. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.

Sedation

Use of this medicine can cause moderate to severe sedation and impairment of physical abilities. Hence, you should avoid work that requires a high level of mental alertness such as driving a vehicle or operating machinery during treatment this medicine.

Fall in blood pressure

Use of this medicine may cause a fall in the blood pressure. It may also cause dizziness and fainting if you get up from a sitting or a lying position suddenly. This risk is especially higher in patients suffering from high blood pressure and taking high blood pressure medications (antihypertensives). Patients are advised to get up slowly from a sitting or a lying position. Close monitoring of blood pressure levels, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Prostate gland disorder

This medicine should be used with caution in patients with a disorder of the prostate gland due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Heart rhythm disorder

This medicine should be used with caution in patients suffering from conduction disorders of the heart. Contact your doctor immediately if the symptoms of your heart condition worsen after taking this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Suicidal thoughts

Use of this medicine is reported to provoke suicidal thoughts and increased suicidal tendencies, especially in young patients. Report any such incidence to the doctor on priority so that counseling and monitoring of progress can be performed at regular intervals.

Withdrawal symptoms

Use of this medicine should not be discontinued abruptly. On abrupt stopping of treatment, you may experience withdrawal symptoms, especially if you have been using this medicine for a prolonged duration. Do not stop the use of this medicine without consulting your doctor.

Pediatric use

This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.

Surgery

Use of this medicine is not recommended if you are planning to undergo a surgery in the near future. Consult your doctor in this regard so that this medicine can be discontinued in an appropriate manner.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious adverse effects such as drowsiness, confusion, impaired judgment, etc. It is advised that you do not perform any activities such as driving a vehicle or operating heavy machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Chloramphenicol

Cisapride

Flavoxate

Omeprazole

Ranitidine

Antidiabetic drugs

Selegiline

Chlorpromazine

Phenobarbital

Diazepam

Guanethidine

Ephedrine

Disease interactions

Heart Disease

This medicine should be used with caution in patients suffering from heart diseases such as heart failure, stroke, heart block, etc. Symptoms such as a fall in blood pressure, rapid change in pulse, dizziness, and other associated complications should be reported to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Glaucoma

This medicine should be used with extreme caution in patients suffering from glaucoma due to the increased risk of worsening of the patient's condition. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Bipolar disorder

This medicine should be used with extreme caution in patients suffering from bipolar disorder due to the increased risk of worsening of the patient's condition. Patients should be monitored closely for any change in mood or behavior during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as instructed by your doctor. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Dosulepin works by altering the levels of certain chemicals called neurotransmitters in the brain. Methylcobalamin works by facilitating the enzymes responsible for the production of vital components and energy inside a cell.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Tricyclic antidepressants, Vitamins

Schedule

Schedule H

Dosulepin - DrugBank [Internet]. Drugbank.ca. 2017 [cited 14 July 2017]. Available from:

https://www.drugbank.ca/drugs/DB09167

Dothiepin hydrochloride: treatment efficacy and safety. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2017 [cited 14 July 2017]. Available from:

https://www.ncbi.nlm.nih.gov/pubmed/3531188

Office of Dietary Supplements - Dietary Supplement Fact Sheet: Vitamin B12 [Internet]. Ods.od.nih.gov. 2017 [cited 9 March 2017]. Available from:

https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/

Office of Dietary Supplements - Vitamin B12 [Internet]. Ods.od.nih.gov. 2017 [cited 9 March 2017]. Available from:

https://ods.od.nih.gov/factsheets/VitaminB12-Consumer/
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