Protamine

Description

Protamine is used as an antidote to treat heparin overdosage and also to reverse the effects of heparin during certain surgeries, especially heart surgery if excessive bleeding occurs.

Side effects

Major & minor side effects for Protamine

  • Nausea and Vomiting
  • Back pain
  • Slow heart rate
  • Skin Reactions
  • Low blood pressure
  • Difficulty in breathing
  • Flushing or redness of skin

Uses of Protamine

What is it prescribed for?

  • Heparin overdosage
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within five minutes following administration.
  • Duration of effect
    The effect of this medicine lasts for an average duration of two hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary and the potential benefits outweigh the risks.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary and the potential benefits outweigh the risks.

Allergy

This medicine is not recommended for use in patients with a known allergy to protamine or any other inactive ingredient present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary and the potential benefits outweigh the risks.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary and the potential benefits outweigh the risks.
General warnings

Hypotension and anaphylactoid reactions

Too rapid administration of this medicine may cause severe hypotension (low blood pressure) and anaphylactoid reactions. Appropriate corrective measures should be taken based on the clinical condition

Missed Dose

Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered only by a qualified healthcare professional. Inform the doctor if the patient has a known history of allergy to this medicine. Report to the doctor all the patient's current medicines as well as medical conditions.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by neutralizing the anticoagulant effects of heparin.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Heparin antagonists, Anticoagulant reversal agents

Schedule

Schedule H

Prosulf 10mg/ml Solution for Injection - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 6 October 2018]. Available from:

https://www.medicines.org.uk/emc/product/8/smpc

[Internet]. Medicines.org.uk. 2018 [cited 6 October 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.8.pdf

TGA eBS - Product and Consumer Medicine Information Licence [Internet]. Ebs.tga.gov.au. 2018 [cited 6 October 2018]. Available from:

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-05963-3

DailyMed - Protamine Sulfate - protamine sulfate injection, solution [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 6 October 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e1964129-33f4-4e4e-86e3-8e6a4e65bd83

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Information on this page was last updated on 22 Aug 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.