Propylthiouracil

Description

Propylthiouracil is used for the treatment of Graves' disease and hyperthyroidism, a condition where the thyroid gland produces an excessive amount of thyroid hormones. It is also used to relieve the symptoms of hyperthyroidism before thyroid surgery or radioactive iodine treatment.

Side effects

Major & minor side effects for Propylthiouracil

  • Black or Tarry stools
  • Chest pain
  • Difficulty or painful urination
  • Shortness of breath
  • Dark colored urine
  • Stomach pain
  • Yellow colored eyes or skin
  • Weakness and general discomfort
  • Hair loss

Uses of Propylthiouracil

What is it prescribed for?

  • Hyperthyroidism
  • Graves Disease
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The effect of this medicine lasts for a maximum duration of 12-24 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to propylthiouracil or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Hepatotoxicity

This medicine should be used with extreme caution in patients suffering from liver diseases due to the increased risk of hepatotoxicity. Close monitoring of liver function tests is necessary while taking this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hypothyroidism

This medicine should be used with caution due to the increased risk of hypothyroidism (low thyroid hormone levels). This risk is especially higher if the medicine is used for a prolonged period of time. Close monitoring of thyroid function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Agranulocytosis

This medicine should be used with extreme caution in patients suffering from agranulocytosis, a condition that affects white blood cells, since it may worsen the patient's condition. Report to the doctor if you experience any unusual symptoms like fever, sore throat, shortness of breath, tiredness, pale skin, etc. immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Bleeding Disorders

This medicine should be used with extreme caution in patients suffering from bleeding disorders due to the increased risk of worsening of the patient's condition. Close monitoring of prothrombin time/INR is necessary while taking this medicine. Appropriate dose adjustment or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Leflunomide

Metoprolol

Fluphenazine

Efavirenz

Carvedilol

Disease interactions

Blood Dyscrasias

This medicine should be used with caution in patients suffering from blood dyscrasias (Thrombocytopenia, Neutropenia, leukopenia, etc.) since it may worsen the patient's condition. Regular monitoring of complete blood count levels is necessary while taking this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients suffering from liver diseases or hepatitis due to the increased risk of hepatotoxicity. Close monitoring of liver functions tests is necessary while taking this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly advised by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It inhibits the synthesis of thyroid hormone to reduce thyroid hormone levels and thus relieves associated symptoms.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antithyroid agents

Schedule

Schedule H

[Internet]. Medicines.org.uk. 2018 [cited 5 December 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.3123.pdf

Propylthiouracil [Internet]. Pubchem.ncbi.nlm.nih.gov. 2019 [cited 19 February 2019]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/propylthiouracil

DailyMed - Propylthiouracil - propylthiouracil tablet [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 19 February 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a57c49ae-d659-49fa-84e3-cf6d1f9e6f97

Propylthiouracil - DrugBank [Internet]. Drugbank.ca. 2019 [cited 19 February 2019]. Available from:

https://www.drugbank.ca/drugs/DB00550

Propylthiouracil: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 19 February 2019]. Available from:

https://medlineplus.gov/druginfo/meds/a682465.html

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Information on this page was last updated on 19 Feb 2019

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.