Propofol

Description

Propofol is a short acting general anesthetic used for inducing and maintaining unconsciousness or sleep during surgical procedures and some medical exams. It should only be administered by a trained healthcare professional. This medicine is not recommended for use in children less than 3 years of age.

Side effects

Major & minor side effects for Propofol

  • Hypersensitivity
  • Irregular heartbeat
  • Decreased heartbeat
  • Hypotension
  • Combativeness
  • Nausea and vomiting
  • Pain at injection site
  • Headache
  • Convulsions (seizures)
  • Difficulty in breathing
  • Kidney failure
  • Injection site Thrombophlebitis

Uses of Propofol

What is it prescribed for?

  • Anesthesia
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 35 to 40 seconds of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 3 to 15 minutes depending on the dose and the rate of infusion.
  • Safe with alcohol?
    Alcohol should not be consumed prior to or after receiving this medicine since it may increase the risk of severe side effects such as respiratory depression, low blood pressure, dizziness, drowsiness, and difficulty concentrating.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to propofol or any other components present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Labor and delivery

This medicine is not recommended for use during procedures associated with labor and delivery.

Drowsiness

This medicine may cause drowsiness, dizziness, and difficulty concentrating. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery after treatment with this medicine.

Hypotension

Patients undergoing anesthesia with Propofol should be monitored closely for early signs of severe hypotension and/or cardiac depression. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Interindividual variability

This medication may show a wide interpatient variability in its effects, similar to other sedative medications. This may warrant changes in dosage requirements.

Allergies to eggs or egg products, soy or soy products

This medicine is not recommended for use in patients who are allergic to egg, egg products, soy, or soy products.

Other Medicines

This medicine may interact with many other medicines and may cause severe side effects. It is advised to inform the doctor about all your current medicines including herbs and supplements before undergoing treatment with this medicine.

Missed Dose

Since this medicine is administered before and during a surgical procedure by a qualified healthcare professional, the likelihood of missing a dose is very low.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Alcohol should not be consumed prior to or after receiving this medicine since it may increase the risk of severe side effects such as respiratory depression, low blood pressure, dizziness, drowsiness, and difficulty concentrating.
Interaction with Medicine

Amiodarone

Selegiline

Alprazolam

Isocarboxazid

Sodium oxybate

Phenelzine

Disease interactions

Cardiovascular disorders

This medicine should be used with extreme caution in patients with cardiovascular disorders due to the increased risk of severe hypotension and/or cardiovascular depression. Close monitoring of heart function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Hyperlipidemia

Since Propofol injection/infusion is an oil-in-water formulation, it may worsen the condition of hyperlipidemic patients. Close monitoring of lipid profile is advised for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Renal Dysfunction

This medicine should be used with caution in patients suffering from renal dysfunction due to the increased risk of worsening of the patient's condition. Close monitoring of renal function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Seizures

This medicine should be used with caution in patients with a history of seizures due to the increased risk of recurrent seizure episodes. Close monitoring of such patients for any signs or symptoms of seizures is recommended. Appropriate corrective measures may be required based on the clinical condition.

Zinc deficiency

Prolonged therapy with Propofol may cause a zinc deficiency. Hence, close monitoring of zinc levels and zinc supplementation as needed is advised in patients who are at an increased risk of zinc deficiency such as those suffering from burns, diarrhea, or sepsis.
Food interactions
Information not available.
Lab interactions
Information not available.
Propofol injection should only be administered by a qualified healthcare professional. Carefully follow all the instructions given by your doctor/healthcare professional. It is advised that you inform the doctor about all your current medicines and medical conditions before undergoing treatment with this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Causes sleepiness

How it works
Propofol works by altering the action of certain natural substances, which in turn induces unconsciousness and sedation.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Sedative hypnotics

Schedule

Schedule H

DIPRIVAN- propofol injection, emulsion [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 1 September 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fee3bd4a-ade3-41fa-839a-48e9af69bcf4

Propofol - DrugBank [Internet]. Drugbank.ca. 2017 [cited 1 September 2017]. Available from:

https://www.drugbank.ca/drugs/DB00818

[Internet]. 2017 [cited 1 September 2017]. Available from:

https://www.medicines.org.uk/emc/PIL.8376.latest.pdf

Propofol [Internet]. Snomedbrowser.com. 2017 [cited 1 September 2017]. Available from:

https://snomedbrowser.com/Codes/Details/387423006

Toxnet [Internet]. Toxnet.nlm.nih.gov. 2017 [cited 1 September 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~ozR4Mg:5

[Internet]. Genome.jp. 2017 [cited 1 September 2017]. Available from:

http://www.genome.jp/dbget-bin/www_bfind_sub?mode=bfind&max_hit=1000&dbkey=all&keywords=propofol

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Information on this page was last updated on 5 Sep 2017

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.