Promethazine

Description

Promethazine is an antihistamine which is used to treat allergic reactions, relieves nausea and vomiting. This medicine is not recommended in patients with asthma and central nervous system depression disorders. This medicine may cause drowsiness, therefore should be used with caution.

Side effects

Major & minor side effects for Promethazine

  • Drowsiness
  • Headache
  • Seizures
  • Tremors
  • Skin rash
  • Loss of strength
  • Increased sensitivity of the skin to sunlight
  • Excitation

Uses of Promethazine

What is it prescribed for?

  • Allergic reactions
  • Sedation
  • Nausea and vomiting
  • Motion sickness
Read More
Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed in 20 minutes after an oral dose and 3 to 5 minutes after an intravenous dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 12 hours.
  • Safe with alcohol?
    Consumption of alcohol is not recommended if the patient is receiving Promethazine. Any symptoms of dizziness, difficulty in concentration should be reported to the doctor. Do not perform activities that require mental alertness. An alternate medicine should be considered based on the clinical condition.
  • Is it habit forming?
    No habit forming tendencies has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine. Monitoring of symptoms like excessive sedation and irritability is necessary while breastfeeding.

Allergy

Not recommended in patients with known allergy to Promethazine.

Asthma

Not recommended in patients with the history of asthma or any respiratory disease.

Central nervous system depression

Not recommended in patients with the history of central nervous system depression.
Warnings for special population

Pregnancy

This medicine is not recommended for pregnant women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before taking this medicine. Monitoring of symptoms like excessive sedation and irritability is necessary while breastfeeding.
General warnings

Drowsiness

Promethazine should be used with caution due to the risk of drowsiness. Do not perform activities that require mental alertness like driving vehicle and operating machinery. It is advised to take this medicine at bedtime.

Seizures

Promethazine may lower the seizure threshold. It is used with caution in patients receiving medicines like narcotics or local anesthetic. Any symptoms of seizures should be informed to the doctor. Do not perform activities that require mental alertness like driving vehicle and operating machinery

Missed Dose

The missed dose can be taken as soon as you remember. However, the missed dose should be skipped if it is almost time for the next dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.

Instructions

Consumption of alcohol is not recommended if the patient is receiving Promethazine. Any symptoms of dizziness, difficulty in concentration should be reported to the doctor. Do not perform activities that require mental alertness. An alternate medicine should be considered based on the clinical condition.
Interaction with Medicine

Escitalopram

Tramadol

Antidiabetic medicines

Antihypertensives

Disease interactions

Asthma

Inform the doctor if you have any respiratory disease. This medicine is not recommended due to the risk of respiratory depression. Any symptoms of breathing difficulty should be informed to the doctor.

Central Nervous System Depression

Inform the doctor if you have any central nervous system disorder or head injury. This medicine is not recommended due to the risk of central nervous system depression. Do not perform activities that require mental alertness.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Promethazine as advised by the doctor. Do not take larger amounts that prescribed. Any symptoms like dizziness and difficulty in concentration should be reported to the doctor. Do not perform activities that require mental alertness like driving vehicle and operating machinery.
Miscelleneous

To be taken before food

To be taken at bedtime only

Causes sleepiness

How it works
It works by inhibiting the binding of histamine to its receptor and thus helps in relieving the symptoms.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antihistamines

Schedule

schedule H

Promethazine - DrugBank [Internet]. Drugbank.ca. 2017 [cited 1 June 2017]. Available from:

https://www.drugbank.ca/drugs/DB01069

[Internet]. 2017 [cited 1 June 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/21162

Promethazine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 1 June 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682284.html

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 1 June 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname

[Internet]. Toxnet.nlm.nih.gov. 2017 [cited 1 June 2017]. Available from:

https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~hQmOer:1

How will this medicine affect me?

Consult top doctors online and get an answer now
Chat now
Chat now

Looking for a doctor?

Book an appointment with the top doctors near you
Book now
Book now
Something doesn’t feel right?
Report an error

Information on this page was last updated on 5 Jan 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.