Promazine

Description

Promazine is used for the short-term treatment of disturbed behavior or psychomotor agitation (a feeling of restlessness that causes an individual to engage in movements that serve no purpose). It may also be used to control severe nausea and vomiting.

Side effects

Major & minor side effects for Promazine

  • Drowsiness
  • Blurred vision
  • Headache
  • Pale skin
  • Dry mouth
  • Stuffy nose
  • Difficulty in breathing
  • Stomach upset
  • Weight gain
  • Constipation

Uses of Promazine

What is it prescribed for?

  • Psychomotor agitation
  • Nausea and vomiting
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe side effects such as dizziness, difficulty in concentration, impaired judgment, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is it habit forming?
    No habit forming tendency has been reported
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to Promazine or any other inactive ingredient present along with the formulation.

Coma

This medicine is not recommended for use in comatose patients due to the increased risk of worsening of the patient's condition.

Severe central nervous system depression

This medicine is not recommended for use in patients with severe central nervous system depression due to an increased risk of serious adverse effects.

Pheochromocytoma

This medicine is not recommended for use in patients with pheochromocytoma (an adrenal gland tumor) due to an increased risk of serious adverse effects.

Bone marrow depression

This medicine is not recommended for use in patients with bone marrow depression due to an increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Glaucoma

This medicine should be used with extreme caution in patients suffering glaucoma (an eye condition that can lead to permanent blindness) due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Use in elderly population

This medicine should be used with extreme caution in the elderly population due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Use in children

This medicine is not recommended for use in children below 18 years of age since the safety and efficacy of use are not clinically established.

Driving or operating machinery

This medicine may cause drowsiness, blurred vision, dizziness, etc. in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms.

QT prolongation

This medicine should be used with extreme caution in patients with a known history of prolonged QT intervals due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Orthostatic hypotension

This medicine is likely to cause a position based decrease in blood pressure especially during the start of therapy. It should be given very carefully to patients who have an active disease of the heart and valves. Any condition leading to a decrease in blood pressure should be given consideration while deciding the dose.

Kidney impairment

This medicine should be used with caution in patients suffering from kidney impairment due to the increased risk of adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver impairment

This medicine should be used with extreme caution in patients suffering from liver impairment due to the increased risk of severe adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Breast cancer

This medicine may increase the prolactin levels in the body and hence should be used with extreme caution in patients with existing or suspected malignancy of the breast. Report any unusual symptoms to the doctor immediately. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

Take/Administer the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe side effects such as dizziness, difficulty in concentration, impaired judgment, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Tramadol

Levodopa

Ciprofloxacin

Atenolol

Diazepam

Disease interactions

Tardive Dyskinesia

This medicine should be used with extreme caution in patients with tardive dyskinesia, a condition of involuntary repetitive body movements, since it may worsen the patient's condition. Report any unusual symptoms to the doctor immediately. Appropriate patient/caregiver education, close monitoring of the patient's condition, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition.

Dementia

This medicine is not recommended for use in patients with dementia-related psychosis due to the increased risk of heart failure, pneumonia, death, etc. This risk is especially high in elderly patients. Replacement with a suitable alternative should be considered under your doctor's supervision.

Neuroleptic Malignant Syndrome (NMS)

This medicine should be used with extreme caution in patients with a known history of a neuroleptic malignant syndrome (NMS) due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Seizures

This medicine should be used with caution in patients with seizure disorders or central nervous system abnormalities due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Cardiovascular disorders

This medicine should be used with extreme caution in patients suffering from cardiovascular diseases due to the increased risk of severe adverse effects. Close monitoring of heart function and blood pressure levels is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Respiratory disorders

This medicine should be used with extreme caution in patients suffering from severe respiratory disorders such as severe asthma, emphysema, or respiratory tract infections due to the increased risk of severe adverse effects. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Parkinson's disease

This medicine may cause pseudo-parkinsonian symptoms such as slow body movements, tremors, pill-rolling motion, postural abnormalities, and gait abnormalities. Hence, this medicine should be used with caution in patients with Parkinson's disease. Report any worsening of the condition to the doctor on priority. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take/Administer this medicine exactly advised by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable effects. Do not stop taking this medicine before completion of the course/without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by binding to certain receptors and thereby blocks the release of chemical substances that cause psychotic symptoms and nausea and vomiting.
Legal Status

Approved

Unknown

Unknown

Approved

Classification

Category

Phenothiazine antipsychotics, Phenothiazine antiemetics

Schedule

Schedule H

[Internet]. Medicines.org.uk. 2020 [cited 5 May 2020]. Available from:

https://www.medicines.org.uk/emc/files/pil.6697.pdf

[Internet]. Medicines.org.uk. 2020 [cited 5 May 2020]. Available from:

https://www.medicines.org.uk/emc/files/pil.6698.pdf

Promazine - DrugBank [Internet]. Drugbank.ca. 2020 [cited 5 May 2020]. Available from:

https://www.drugbank.ca/drugs/DB00420

Promazine [Internet]. Pubchem.ncbi.nlm.nih.gov. 2020 [cited 5 May 2020]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Promazine

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Information on this page was last updated on 14 May 2020

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.