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Proloc-D Capsule
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Proloc-D Capsule

Manufactured byComed Chemicals Ltd.
ContainsDomperidone (10 mg) + Pantoprazole (20 mg)
Description
Proloc-D Capsule is a combination of Domperidone and Pantoprazole. It is used in the treatment of peptic ulcers (sores that occur on the lining of your stomach and the upper region of your small intestine) and gastroesophageal reflux disease (a condition where the stomach acid flows back into the food pipe and damages it). These conditions lead to symptoms such as heartburn, discomfort in the stomach, vomiting sensation, and difficulty in swallowing food. Proloc-D Capsule reduces the sensation of nausea and decreases the production of stomach acid. Thus, it helps to heal ulcers. Proloc-D Capsule shows some common side effects like headache, dry mouth, stomach pain/discomfort, diarrhoea, and dizziness. Consult your doctor if these side effects bother you. Proloc-D Capsule should be taken one hour before your meal. The dose and duration of treatment will be decided by your doctor. You should take this medicine for the complete duration prescribed by your doctor. If you stop this medicine early, your symptoms may reappear or your condition may worsen. Proloc-D Capsule should be avoided if you are allergic to it. Inform your doctor if you have liver, kidney, heart, and/or bone problems, or if you are taking any medications. Proloc-D Capsule is not recommended for use in children below 12 years of age due to limited safety and efficacy data. Consult your doctor if you are pregnant, or are breastfeeding before taking this medicine.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Proloc-D Capsule

  • Headache
  • Altered sense of taste
  • Diarrhoea
  • Unusual tiredness and weakness
  • Skin Rash
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Difficulty in breathing
  • Irregular heart beat
  • Disrupted menstrual cycle
  • Breast pain and tenderness
  • Dry mouth
  • Dizziness

Uses of Proloc-D Capsule

What is it prescribed for?

  • Gastroesophagal Reflux Disease
  • Peptic Ulcer
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of Proloc-D Capsule is seen within 30 to 60 minutes.
  • How long do the effects of this medicine last?
    The effect of Proloc-D Capsule remains in your body for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit forming tendencies were reported for Proloc-D Capsule.
  • Can this medicine be taken during pregnancy?
    Proloc-D Capsule is usually not recommended for use during pregnancy. Hence, consult your doctor if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    Proloc-D Capsule may pass into breastmilk and may harm your baby. Hence, consult your doctor if you are breastfeeding.

Allergy

Avoid taking Proloc-D Capsule if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling of the face/tongue/throat, breathing difficulty, etc.

Prolactinoma

Prolactinoma is a tumour of the pituitary gland which leads to an increase in prolactin (a hormone responsible for milk production in lactating women). It occurs more often in women compared to men. The symptoms in women are infertility, irregular periods, and acne. Avoid taking Proloc-D Capsule as it worsens your condition.

Heart diseases

Proloc-D Capsule may cause irregular heartbeat. Hence, this medicine is not recommended if you have pre-existing heart conditions like congestive heart failure (a condition in which your heart is not able to pump sufficient blood throughout the body), QT prolongation (heart muscle takes longer than normal to recharge between a heartbeat), etc., as it may worsen your health condition.

Moderate to severe liver impairment

Proloc-D Capsule is broken down in the liver. Hence, this medicine is not recommended if you have moderate to severe liver problems.
Warnings for special population

Pregnancy

Proloc-D Capsule is usually not recommended for use during pregnancy. Hence, consult your doctor if you are pregnant.

Breast-feeding

Proloc-D Capsule may pass into breastmilk and may harm your baby. Hence, consult your doctor if you are breastfeeding.
General warnings

Other medicines

Inform your doctor about the use of all your medicines including any herbs and supplements as Proloc-D Capsule may interact with other medications and cause side effects.

Use in children

Proloc-D Capsule is not recommended for use in children below 12 years of age as there is no safety and efficacy established.

Use in elderly

Proloc-D Capsule should be used with caution in elderly people. The activity of the liver and kidney decreases with age and this may lead to an increased risk of side effects while taking this medicine.

Prolactin imbalance

Taking Proloc-D Capsule for a long time or at higher doses increases the level of prolactin hormone in your body. This may lead to side effects like infertility and irregular periods. The increased levels of prolactin may fall to normal after discontinuation of the medicine.

Driving or operating machines

Proloc-D Capsule may cause visual disturbances or dizziness. Hence, avoid driving vehicles and operating heavy machines after taking this medicine until you know how this medicine affects you.

Effect on heart

Proloc-D Capsule can increase the risk of abnormal heartbeat or other heart problems. The risk may be higher if you are older than 60 years or if you are taking a higher dose of this medicine.

Missed Dose

Try not to skip the dose of Proloc-D Capsule. In case you missed a dose, take it as soon as you remember. If the delay is more than 12 hours, skip the dose. Do not take a double dose.

Overdose

Never take more than the prescribed dose of Proloc-D Capsule. In case of an overdose, seek immediate medical attention.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Ketoconazole

Methotrexate

Warfarin

Nelfinavir

Digoxin

Disease interactions

Osteoporosis

Osteoporosis is a condition in which bones become weak. This medicine decreases calcium absorption in your body leading to a deficiency of calcium required to maintain bone density. Hence, long-term use of Proloc-D Capsule is not recommended as it can lead to decreased bone strength. Your doctor may suggest tests to monitor your bone health and mineral status.

Hypomagnesaemia

Long-term use of Proloc-D Capsule may result in hypomagnesaemia (low magnesium levels in your blood). Inform your doctor if you experience any symptoms such as dizziness, irregular heartbeat, shivering, muscle pain, seizures (fits), etc. Your doctor may suggest tests to monitor the magnesium levels in your blood at regular intervals. Consult your doctor if you have any concerns.

Kidney Disease

If you have severe kidney problems use Proloc-D Capsule with caution as prolonged use may increase the accumulation of this medicine in your body.
Food interactions
Information not available.
Lab interactions

Tetrahydrocannabinol (THC)

There may be a false-positive result of urine screening for tetrahydrocannabinol if you are taking Proloc-D Capsule. Inform your doctor or lab technician about the use of this medicine before the lab test.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Proloc-D Capsule one hour before meal. Swallow it with an adequate amount of water. Do not chew or crush the tablet. Avoid taking more than the prescribed dose. Take this medicine for the recommended duration. Avoid taking food and drinks such as peppermint, chocolates, spicy food, coffee, alcoholic drinks, etc. as it may worsen your symptoms. Avoid driving and operating heavy machines as this medicine may cause visual disturbances and dizziness.
Miscelleneous

To be taken before food

To be taken as instructed by doctor

May cause sleepiness

How it works
Proloc-D Capsule is a combination of two medicines; Domperidone and Pantoprazole. This combination works effectively in reducing stomach acid and preventing vomiting. Domperidone works by increasing the movement of the food through your stomach into the intestine thus, it prevents vomiting. Pantoprazole works by decreasing the production of acid in your stomach.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Antiemetics, Proton pump inhibitors

Schedule

Schedule H

Pubchem.ncbi.nlm.nih.gov. 2021. Domperidone. [online] Available at: < [Accessed 10 August 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Domperidone>

Pubchem.ncbi.nlm.nih.gov. 2021. Pantoprazole. [online] Available at: < [Accessed 10 August 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/Pantoprazole>

Medicines.org.uk. 2021. Pantoprazole 20 mg gastro-resistant tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 8 October 2021].

https://www.medicines.org.uk/emc/product/7089/smpc>

Medicines.org.uk. 2021. Domperidone 10mg Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 5 August 2021].

https://www.medicines.org.uk/emc/product/556/smpc#gref>

nhs.uk. 2021. Domperidone: anti-sickness medicine used to treat nausea and vomiting. [online] Available at: < [Accessed 6 August 2021].

https://www.nhs.uk/medicines/domperidone/>

Medicineindia.org. 2021. Pantoprazole + Domperidone Pharmacology & Usage Details | Medicine India. [online] Available at: < [Accessed 6 August 2021].

https://www.medicineindia.org/pharmacology-for-generic/1360/pantoprazole-domperidone>
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Information on this page was last updated on 19 Oct 2021

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