Procreval 40 mg Injection

Manufactured byRANBAXY LABORATORIES LTD
ContainsParecoxib
Description

Procreval 40 mg Injection is a selective COX-2 inhibitor used for short-term treatment of post-operative pain in adults. This medicine is not recommended for use in patients below 18 years of age.

Substitutes

List of substitutes for Procreval 40 mg Injection

Side effects

Major & minor side effects for Procreval 40 mg Injection

  • Abdominal pain
  • Vomiting
  • Constipation
  • Indigestion
  • Flatulence
  • Dizziness
  • Decreased potassium levels
  • Sore throat
  • Anorexia
  • Decreased heartbeat

Uses of Procreval 40 mg Injection

What is it prescribed for?

  • Post operative pain
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to parecoxib, valdecoxib, any other non-steroidal anti-inflammatory (NSAID) drugs, or any other inactive ingredients present along with this medicine.

Severe Hepatic impairment

This medicine is not recommended for use in patients with a known history of severe hepatic impairment due to the increased risk of worsening of the patient's condition.

Coronary Artery Bypass Surgery (CABG)

This medicine is not recommended for use before, during, or after a coronary artery bypass graft surgery due to the increased risk of severe adverse reactions.

Congestive Heart Failure

This medicine is not recommended for use in patients with a known history of severe congestive heart failure due to the increased risk of worsening of the patient's condition.

Gastro-intestinal bleeding

This medicine is not recommended for use in patients with a known history of gastrointestinal bleeding due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.
General warnings

Cardiovascular diseases

This medicine should be used with caution in patients with a known history of cardiovascular diseases due to the increased risk of worsening of the patient's condition. Close monitoring of vital signs and heart function, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Renal impairment

This medicine should be used with caution in patients with a known history of kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Gastro-Intestinal Bleeding

This medicine may cause severe bleeding when taken for a long time. This risk is especially high in the elderly population with a history of gastrointestinal diseases. Report any symptoms of blood in stools and vomiting to the doctor immediately. Replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or Operating machines

This medicine may cause symptoms such as dizziness in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery if you experience dizziness during treatment with this medicine.

Use in pediatrics

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, on an as-needed basis, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered by a qualified healthcare professional in the hospital or clinical setting, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Antihypertensives

Tacrolimus

Cyclosporine

Disease interactions

Hepatic impairment

This medicine should be used with caution in patients with a known history of liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is administered by a qualified healthcare professional in the clinical or hospital setting. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines as well as your medical conditions before receiving this medicine. Report any undesired side effects to the doctor immediately.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by inhibiting the formation of certain chemical substances in the body that are responsible for causing pain and swelling.
Legal Status

Approved

Unknown

Unknown

Approved

Classification

Category

Non-steroidal anti-inflammatory agents

Schedule

Schedule H

Parecoxib - DrugBank [Internet]. Drugbank.ca. 2018 [cited 22 March 2018]. Available from:

https://www.drugbank.ca/drugs/DB08439

[Internet]. 2018 [cited 22 March 2018]. Available from:

https://www2.medicines.org.uk/emc/medicine/8771#

[Internet]. 2018 [cited 22 March 2018]. Available from:

https://www2.medicines.org.uk/emc/PIL.14520.latest.pdf

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2018 [cited 22 March 2018]. Available from:

http://www.tga.gov.au/prescribing-medicines-pregnancy-database

[Internet]. Pfizer.com.au. 2018 [cited 22 March 2018]. Available from:

http://www.pfizer.com.au/sites/g/files/g10005016/f/201311/PI_Dynastat_306.pdf

[Internet]. Medsafe.govt.nz. 2018 [cited 22 March 2018]. Available from:

http://www.medsafe.govt.nz/Consumers/CMI/d/dynastat.pdf

[Internet]. E-lactancia.org. 2018 [cited 22 March 2018]. Available from:

http://www.e-lactancia.org/media/papers/Parecoxib-DS2012.pdf
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