Procaine Penicillin G

Description

Procaine Penicillin G is a combination of natural benzylpenicillin (penicillin G) and the local anesthetic agent procaine in equimolar amounts which is used to treat moderately severe bacterial infections caused due to penicillin-sensitive microorganisms.

Side effects

Major & minor side effects for Procaine Penicillin G

  • Fever
  • Skin rash
  • Diarrhea
  • Muscle pain
  • Dizziness
  • Headache
  • Slow heart rate
  • Pain at injection site
  • Nausea and vomiting
  • Blurred vision
  • White patches in the mouth or on the tongue

Uses of Procaine Penicillin G

What is it prescribed for?

  • Staphylococcal Infections
  • Streptococcal Infections
  • Bacterial endocarditis
  • Diphtheria
  • Erysipeloid
  • Syphilis
  • Rat-bite fever
  • Anthrax
  • Whipple's disease
Read More
Concerns

Commonly asked questions

  • Onset of action
    The amount of time taken by this medicine to show its effect is not clinically well established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. If the medicine is used, the infant should be monitored closely for any adverse effects.

Allergy

This medicine is not recommended for use in patients with a known allergy to procaine penicillin G, any other antibiotic of the penicillin or any other inactive ingredients present along with it.

Gonorrhea

This medicine is not recommended for the treatment of gonorrhea.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. If the medicine is used, the infant should be monitored closely for any adverse effects.
General warnings

Kidney impairment

This medicine should be used with caution in patients with an impaired kidney function due to the increased risk of severe adverse effects. Close monitoring of kidney function tests, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Drug-resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing benefits and may even cause toxicity. It may also increase the risk of development of bacteria that are drug-resistant.

Hypersensitivity reactions

This medicine may cause serious and occasionally fatal hypersensitivity reactions including anaphylactic shock in some patients. This risk is especially high in patients with a history of sensitivity to multiple allergens. If an anaphylactic reaction occurs, the treatment should be discontinued immediately and appropriate corrective measures should be undertaken.

Route of administration

This medicine is recommended for deep intramuscular administration only. Do not administer this medicine into or near an artery or nerve due to the risk of severe adverse effects.

Driving or operating machinery

Use of this medicine may cause symptoms such as lightheadedness, blurred vision, fainting, dizziness, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low. If you miss any scheduled dosing of this medicine, contact your doctor immediately for further instructions.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Live attenuated vaccines and related products

Methotrexate

Tetracycline

Ethinyl Estradiol

Warfarin

Disease interactions

Colitis

This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, since it may worsen the patient's condition. Report any incidence of severe diarrhea, abdominal pain, blood in stools, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Methemoglobinemia

This medicine may cause a blood disorder where there is an elevated level of methemoglobin produced in the blood. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional in the clinical or hospital setting. Inform the doctor if you have a known allergy to this medicine. Report to the doctor all your current medicines including herbs and supplements as well as all your medical conditions before receiving this medicine. Report any undesired side effects to the doctor.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by stopping the growth of bacteria by inhibiting its cell wall synthesis.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Penicillins

Schedule

Schedule H

Penicillin G Procaine (penicillin G procaine) | Pfizer Medical Information - US [Internet]. Pfizermedicalinformation.com. 2019 [cited 13 September 2019]. Available from:

https://www.pfizermedicalinformation.com/en-us/penicillin-g-procaine

Procaine Benzylpenicillin - DrugBank [Internet]. Drugbank.ca. 2019 [cited 13 September 2019]. Available from:

https://www.drugbank.ca/drugs/DB09320

Penicillin G Procaine Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 16 September 2019]. Available from:

https://medlineplus.gov/druginfo/meds/a615052.html

DailyMed - Penicillin G Procaine- penicillin g procaine injection, suspension [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 16 September 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=07fe2b47-34ac-4a20-be67-3c788c77b207

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Information on this page was last updated on 16 Sep 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.