Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition
General warnings
Elderly patients
This medicine should be used with caution in elderly patients due to the increased risk of severe adverse effects. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Other medicines
This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.
Gastrointestinal surgery
This medicine should be used with caution in patients who have had recent surgery of the stomach or intestines due to the increased risk of adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Use of antacids
Coadministration of antacids and this combination medicine may reduce the absorption of this medicine. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.
Kidney impairment
This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.
Suicidal tendencies
This medicine may cause suicidal ideation in some patients. Hence, it should be used with extreme caution, especially in patients suffering from suicidal tendencies or any psychological disorders. Close monitoring of mood and behavior is recommended for such patients. Replacement with a suitable alternative should be considered based on the clinical condition of the patient.
Driving or operating machinery
This medicine may cause drowsiness or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.
High creatinine kinase levels
This medicine should be used with caution in patients having a blood clotting disorder or high levels of creatinine kinase in the blood.
Use in children
This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.
Male mediated teratogenicity
This medicine has been associated with a defect in sperm and may cause a defect in the baby. It should be used with caution in males who are planning to father a baby in the near future.
Potential for abuse
This medicine can cause dependence, especially in patients who are chronic alcohol users or have used other recreational drugs in the past. Report the past use of alcohol or other drugs to the doctor before receiving this medicine. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary for such patients based on the clinical condition.
Edema
This medicine can cause fluid retention in the body and hence, it should be used with caution in patients suffering from any fluid retention disorders. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary for such patients based on the clinical condition.
Heart block
This medicine can cause heart rhythm abnormalities which could result in blockage and associated complications. Hence, it should be used with caution in patients having a disease of the heart and blood vessels. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary for such patients based on the clinical condition.
Rhabdomyolysis
This medicine has been associated with rare cases of muscle breakdown disorders that affect kidneys. You should report any instance of muscle pain, weakness, the presence of dark reddish coloration of urine, etc. to the doctor on priority. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary for such patients based on the clinical condition.