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Prenura Plus Capsule

Manufactured byPULSE PHARMACEUTICALS PVT LTD
ContainsAlpha lipoic acid (100 mg) + Folic Acid (1.5 mg) + Methylcobalamin (750 mcg) + Pregabalin (75 mg)
Description

Prenura Plus Capsule is a combination medicine which may be used for treating painful diabetic neuropathy in adult patients only.

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Side effects

Major & minor side effects for Prenura Plus Capsule

  • Nausea and vomiting
  • Decreased appetite or loss of appetite
  • Skin rash
  • Chest pain and discomfort
  • Stomach discomfort and pain
  • Sweating
  • Difficulty in breathing
  • Chills
  • Severe diarrhea
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Unusual tiredness and weakness
  • Blurred or double vision
  • Dry mouth
  • Memory problem
  • Loss of coordination
  • Fever

Uses of Prenura Plus Capsule

What is it prescribed for?

  • Diabetic Neuropathy
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of drowsiness, dizziness, and difficulty in concentrating. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
  • Is this a habit forming medicine?
    This medicine has a low abuse potential with limited physical and psychological dependence.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition

Leber's Disease

This medicine is not recommended for use in patients suffering from Leber's Disease, a rare genetic disorder, due to the increased risk of worsening of the patient's condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to alpha lipoic acid, folic acid, methylcobalamin, pregabalin, or any other inactive ingredients present along with the formulation.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition
General warnings

Elderly patients

This medicine should be used with caution in elderly patients due to the increased risk of severe adverse effects. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Other medicines

This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Gastrointestinal surgery

This medicine should be used with caution in patients who have had recent surgery of the stomach or intestines due to the increased risk of adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Use of antacids

Coadministration of antacids and this combination medicine may reduce the absorption of this medicine. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.

Kidney impairment

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Suicidal tendencies

This medicine may cause suicidal ideation in some patients. Hence, it should be used with extreme caution, especially in patients suffering from suicidal tendencies or any psychological disorders. Close monitoring of mood and behavior is recommended for such patients. Replacement with a suitable alternative should be considered based on the clinical condition of the patient.

Driving or operating machinery

This medicine may cause drowsiness or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

High creatinine kinase levels

This medicine should be used with caution in patients having a blood clotting disorder or high levels of creatinine kinase in the blood.

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Male mediated teratogenicity

This medicine has been associated with a defect in sperm and may cause a defect in the baby. It should be used with caution in males who are planning to father a baby in the near future.

Potential for abuse

This medicine can cause dependence, especially in patients who are chronic alcohol users or have used other recreational drugs in the past. Report the past use of alcohol or other drugs to the doctor before receiving this medicine. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary for such patients based on the clinical condition.

Edema

This medicine can cause fluid retention in the body and hence, it should be used with caution in patients suffering from any fluid retention disorders. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary for such patients based on the clinical condition.

Heart block

This medicine can cause heart rhythm abnormalities which could result in blockage and associated complications. Hence, it should be used with caution in patients having a disease of the heart and blood vessels. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary for such patients based on the clinical condition.

Rhabdomyolysis

This medicine has been associated with rare cases of muscle breakdown disorders that affect kidneys. You should report any instance of muscle pain, weakness, the presence of dark reddish coloration of urine, etc. to the doctor on priority. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary for such patients based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of drowsiness, dizziness, and difficulty in concentrating. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
Interaction with Medicine

Capecitabine

Chloramphenicol

Lorazepam

Ranitidine

Antidiabetic medicines

Buprenorphine

Oxycodone

Fluorouracil

Propoxyphene

ACE inhibitors

Disease interactions

Angioedema

This medicine should be used with caution in patients with a known history of angioedema or patients at risk of developing swelling of the inner layers of the skin since it may worsen the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as instructed by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor. Usage of this medicine should not be stopped abruptly since this may cause severe withdrawal symptoms.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Alpha lipoic acid slows down cellular damage and helps to restore levels of essential vitamins such as vitamin E and vitamin C. Folic acid are essential for the production of certain vital components that are necessary for the maintenance of normal body functions. Methylcobalamin works by facilitating the enzymes responsible for the production of vital components and energy inside a cell. Pregabalin acts by reducing certain chemical transmitters in the brain and slowing down nerve impulses. Thus, this combination is better effective in treating painful diabetic neuropathy.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Gamma-aminobutyric acid analogs, Vitamins

Schedule

Schedule H

Pregabalin | C8H17NO2 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 7 April 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/5486971

Pregabalin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 7 April 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a605045.html

Methylcobalamin hydrate | C63H93CoN13O15P - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 9 March 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/91886214#section=Top

Folic Acid - DrugBank [Internet]. Drugbank.ca. 2017 [cited 30 May 2017]. Available from:

https://www.drugbank.ca/drugs/DB00158

Lipoic Acid - DrugBank [Internet]. Drugbank.ca. 2017 [cited 18 October 2017]. Available from:

https://www.drugbank.ca/drugs/DB00166
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Information on this page was last updated on 12 Jul 2019

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