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Premarin Vaginal Cream
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Premarin Vaginal Cream

Manufactured byPFIZER LTD
ContainsConjugated Estrogens
Description
Premarin Vaginal Cream is a mixture of estrogen hormones, produced by the ovaries. This medicine is used to treat vaginal atrophy and post-menopause symptoms such as hot flashes, vaginal drying, and itching, etc.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Premarin Vaginal Cream

  • Vaginal bleeding
  • Vaginal discharge

Uses of Premarin Vaginal Cream

What is it prescribed for?

  • Vaginal atrophy
  • Post menopausal symptoms
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    Use of this medicine is not recommended if you are pregnant or planning a pregnancy in immediate future. Contact your doctor if you suspect a pregnancy while being treated with this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.

Allergy

This medicine is not recommended for use in patients who have a known allergy to estrogen products or any other inactive ingredients present in the formulation.

Undiagnosed vaginal bleeding

This medicine is not recommended for use if you have an abnormal episode of vaginal bleeding which was not diagnosed.

Estrogen-dependent tumor

This medicine is not recommended for use in patients having cancer which is attributed to abnormal levels of the hormone estrogen in the body for a prolonged duration.
Warnings for special population

Pregnancy

Use of this medicine is not recommended if you are pregnant or planning a pregnancy in immediate future. Contact your doctor if you suspect a pregnancy while being treated with this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine.
General warnings

Abnormal vaginal bleeding

This medicine should not be given to women having undiagnosed abnormal vaginal bleeding. Appropriate tests should be performed to rule out cancer in all cases of abnormal and persistent bleeding before treatment is initiated.

Use in Children

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Apply the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not apply a double dose to make up for the missed one.

Overdose

An overdose of this medicine is not likely to cause severe symptoms unless it is applied for a prolonged period of time in large volumes. However, ingestion of this medicine may cause harm and immediate medical intervention may be required.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Thalidomide

Acarbose

Lenalidomide

Carfilzomib

Disease interactions

Abnormal vaginal bleeding

This medicine should be used with caution if the patient has had an episode of abnormal vaginal bleeding especially if the intended use is for a long duration. It is advised to undergo a diagnostic test to ascertain the reason for the abnormal bleeding. Conditions like endometrial hyperplasia should be ruled out before starting the therapy with estradiol.

Estrogen-dependent tumor

This medicine is not recommended for use in patients having a tumor caused due to abnormal levels of estrogen in the body. The tumor may be of the endometrium or the breasts. Suitable diagnostic tests should be performed before starting treatment with estradiol.

Hypertension

This medicine should be used with extreme caution in patients having high blood pressure. The risk of adverse effects on the heart and blood vessels are extremely high in such cases. Suitable dose adjustment and safety monitoring is a must in such cases.

Hepatic neoplasms

Use of this medicine is not recommended if the patient has cancer of the liver is suspected of having it. Your doctor may decide the best course of treatment after assessing the condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Follow all the usage instructions mentioned on the label or the package insert. Do not apply in larger or smaller quantities than recommended. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Effect on sleep is not established

How it works
This medicine works by replacing or replenishing the hormone estrogen that is normally produced in the body.
Legal Status

Approved

Approved

Unknown

Unknown

Classification

Category

Estrogens

Schedule

Schedule H

Conjugated estrogens - DrugBank [Internet]. Drugbank.ca. 2018 [cited 27 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00286

Safety Info | About | PREMARIN® (conjugated estrogens) Vaginal Cream [Internet]. Premarinvaginalcream.com. 2020 [cited 21 February 2020]. Available from:

https://www.premarinvaginalcream.com/about

Premarin [Internet]. Pubchem.ncbi.nlm.nih.gov. 2020 [cited 24 February 2020]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Premarin
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Information on this page was last updated on 27 Apr 2020

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.