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Premarin Tablet
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Premarin Tablet

Manufactured byPFIZER LTD
ContainsConjugated Estrogens
Description
Premarin Tablet is a mixture of oestrogen hormones. It is used for the treatment of hormone-mediated diseases like osteoporosis (a condition leading to brittle and fragile bones), some forms of breast cancers, prostate cancer, etc. It is also used to treat the symptoms of menopause (time that marks the end of the menstrual cycle) like hot flashes, vaginal drying, and itching, etc. Premarin Tablet works by replacing or replenishing the hormone oestrogen that is normally produced in the body. It can cause side effects like headache, body ache, tiredness etc. Most of these are temporary and resolve on their own. Consult your doctor if these side effects are persistent or worsening. Avoid driving vehicles or operating machines after taking this medicine as it can make you feel dizzy. Premarin Tablet is usually taken with food to avoid stomach irritation. Take this medicine at the same time every day to maintain a constant level of medicine in your body. Do not stop taking this medicine without consulting your doctor as your symptoms may reoccur. Premarin Tablet is not recommended if you are allergic to it. Inform your doctor all about your current medications and existing medical conditions. This will help your doctor to adjust your dose for avoiding side effects. If you are pregnant or breastfeeding, consult your doctor before using this medicine.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Premarin Tablet

  • Body aches or pain
  • Cough
  • Difficulty in breathing
  • Headache
  • Unusual tiredness or weakness
  • Dark urine
  • Vaginal discharge
  • Dizziness
  • Hair loss
  • Weight loss or weight gain

Uses of Premarin Tablet

What is it prescribed for?

  • Post menopausal symptoms
  • Female hypogonadism
  • Palliative treatment of breast and prostate cancer
  • Primary ovarian failure
  • Vaginal atrophy
  • Postmenopausal osteoporosis
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for Premarin Tablet to show its action is not clinically established.
  • How long do the effects of this medicine last?
    Premarin Tablet may remain in your body for four to five days.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported for Premarin Tablet.
  • Can this medicine be taken during pregnancy?
    Premarin Tablet is not recommended if you are pregnant or planning a pregnancy. Contact your doctor if you suspect pregnancy while being treated with this medicine.
  • Can this medicine be taken while breast-feeding?
    Premarin Tablet is not recommended if you are breastfeeding. Consult your doctor to understand all risks and benefits before taking this medicine.

Allergy

Premarin Tablet is not recommended if you are allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of your face/tongue/throat), severe dizziness, breathing difficulty, etc.

Undiagnosed genital bleeding

Premarin Tablet is not recommended for use if you have an abnormal episode of genital bleeding which was not diagnosed. Taking this medicine in such a case may worsen your condition.

Heart and blood vessel disorder

Premarin Tablet is not recommended for use if you have/had any condition of heart or blood vessels as it can aggravate such conditions.

Breast cancer

Premarin Tablet is not recommended for use if you have a history of breast cancer (except for end-stage). It can increase the severity or risk of breast cancer.

Liver Disease

Premarin Tablet is not recommended for use if you have liver problems. This medicine is broken down and absorbed in the liver. If you have liver problems, this medicine cannot be absorbed and increases the risk of toxicity.

Estrogen-dependent tumor

Premarin Tablet is not recommended for use if you have an oestrogen-dependent tumour as this medicine increases oestrogen levels in your body which may worsen your condition.
Warnings for special population

Pregnancy

Premarin Tablet is not recommended if you are pregnant or planning a pregnancy. Contact your doctor if you suspect pregnancy while being treated with this medicine.

Breast-feeding

Premarin Tablet is not recommended if you are breastfeeding. Consult your doctor to understand all risks and benefits before taking this medicine.
General warnings

Kidney disease

Premarin Tablet should be used with caution if you have kidney problems as an affected kidney cannot filter the medicine properly. This can increase the risk of toxicity.

Use in children

Premarin Tablet is not recommended for use in children below 18 years of age as the safety and efficacy data of use are not clinically established.

Jaundice like symptoms

Use of Premarin Tablet can cause yellowing of the eyes and skin due to its effect on the liver and the gall bladder. If you develop such symptoms, inform your doctor immediately.

Driving or operating machinery

Use of Premarin Tablet may cause blurred vision or dizziness. It is advised that you do not perform any activities such as driving vehicles or operating machines if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Take the missed dose of Premarin Tablet as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment in case of an overdose of Premarin Tablet.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Thalidomide

Efavirenz

Acarbose

Lenalidomide

Carfilzomib

Disease interactions

Hypertension

Premarin Tablet should be used with extreme caution if you have high blood pressure as this medicine can increase your heart rate and blood pressure. Your doctor may frequently monitor your blood pressure and/or adjust your dose if required.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Take Premarin Tablet as instructed by your doctor. Drink plenty of water with it to avoid stomach irritation. Do not break, crush or chew the tablet. Premarin Tablet is given for a long period. Therefore, do not stop taking this medicine even if you feel better after a few doses. Do not take in larger amounts than prescribed. Consult your doctor if you experience any undesirable effects. It is advised to do regular follow-ups with your doctor while taking this medicine.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Premarin Tablet works by replacing or replenishing the hormone oestrogen that is normally produced in the body.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Estrogens

Schedule

Schedule H

Medicines.org.uk. 2021. Premarin 0.625 mg Coated Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 25 November 2021].

https://www.medicines.org.uk/emc/product/2900/smpc>

S3-us-west-2.amazonaws.com. 2021. [online] Available at: < [Accessed 25 November 2021].

https://s3-us-west-2.amazonaws.com/drugbank/fda_labels/DB00286.pdf?1471370910>

Dailymed.nlm.nih.gov. 2021. DailyMed - PREMARIN- conjugated estrogens tablet, film coated. [online] Available at: < [Accessed 25 November 2021].

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1fcd61a8-1a67-4785-a51a-45fca6fbb32b&audience=consumer>
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Information on this page was last updated on 25 Nov 2021

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