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Pregeb Forte 75 Capsule

Manufactured byTORRENT PHARMACEUTICALS LTD
ContainsAlpha lipoic acid (100 mg) + Folic Acid (1.5 mg) + Methylcobalamin (750 mcg) + Pregabalin (75 mg) + Pyridoxine (3 mg)
Description

Pregeb Forte 75 Capsule is a combination medicine used for treating painful diabetic neuropathy in adult patients only.

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Side effects

Major & minor side effects for Pregeb Forte 75 Capsule

  • Nausea and vomiting
  • Decreased appetite or loss of appetite
  • Skin rash
  • Chest pain and discomfort
  • Clumsiness
  • Numbness of hands or feet
  • Unsteady walk
  • Sleepiness
  • Stomach discomfort and pain
  • Sweating
  • Difficulty in breathing
  • Chills
  • Severe diarrhea
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Unusual tiredness and weakness
  • Blurred or double vision
  • Dry mouth
  • Memory problem
  • Loss of coordination
  • Fever

Uses of Pregeb Forte 75 Capsule

What is it prescribed for?

  • Diabetic Neuropathy
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of drowsiness, dizziness, and difficulty in concentrating. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
  • Is this a habit forming medicine?
    This medicine has a low abuse potential with limited physical and psychological dependence.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition

Leber's Disease

This medicine is not recommended for use in patients suffering from Leber's Disease, a rare genetic disorder, due to the increased risk of worsening of the patient's condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to alpha lipoic acid, folic acid, methylcobalamin, pregabalin, pyridoxine, or any other inactive ingredients present along with these medicines.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before using this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition
General warnings

Elderly patients

Few elderly patients may have a reduced capacity to absorb this medicine through the intestine. Appropriate dose adjustments and frequent clinical monitoring are necessary for such patients during treatment with this medicine.

Other medicines

Many medicines may interact with this medicine and may decrease the absorption of this medicine as well as cause severe adverse effects. Hence, it is advised that you report to the doctor all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Gastrointestinal surgery

Patients who have had a recent gastrointestinal surgery may have reduced absorption of this medicine. Appropriate dose adjustments should be done under your doctor's supervision.

Use of antacids

Coadministration of antacids and this combination medicine may reduce the absorption of this medicine. Appropriate dose adjustments or replacement with a suitable alternative should be done under your doctor's supervision.

Renal impairment

This medicine should be administered with caution in patients having an impaired kidney function due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Suicidal tendencies

This medicine can cause suicidal ideation and hence, it should be used with extreme caution, especially in patients who have displayed such tendencies in past. Close monitoring of mood and behavior is recommended for such patients. Replacement with a suitable alternative may be necessary in some cases based on the clinical condition of the patient.

Driving or operating machinery

Use of this medicine may cause symptoms such as blurred vision, drowsiness, dizziness, etc. in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

High creatinine kinase levels

This medicine should be used with caution in patients having a blood clotting disorder or high levels of creatinine kinase in the blood.

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Male mediated teratogenicity

This medicine has been associated with a defect in sperm and may cause a defect in the baby. It should be used with caution in males who are planning to father a baby in near future.

Potential for abuse

This medicine can cause dependence, especially in patients who are chronic alcohol users or have used other recreational drugs in the past. Report the past use of alcohol or other drugs to the doctor before receiving this medicine. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary for such patients based on the clinical condition.

Edema

This medicine can cause fluid retention in the body and hence, it should be used with caution in patients suffering from any fluid retention disorders. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary for such patients based on the clinical condition.

Heart block

This medicine can cause heart rhythm abnormalities which could result in blockage and associated complications. Hence, it should be used with caution in patients having a disease of the heart and blood vessels. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary for such patients based on the clinical condition.

Rhabdomyolysis

This medicine has been associated with rare cases of muscle breakdown disorders that affect kidneys. You should report any instance of muscle pain, weakness, the presence of dark reddish coloration of urine, etc. to the doctor on priority. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be necessary for such patients based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while receiving this medicine as it may increase the risk of drowsiness, dizziness, and difficulty in concentrating. Avoid performing activities that need high mental alertness like driving a vehicle or operating heavy machinery if alcohol and this medicine are used together.
Interaction with Medicine

Capecitabine

Chloramphenicol

Lorazepam

Ranitidine

Antidiabetic drugs

Buprenorphine

Levodopa

Phenobarbital

Oxycodone

Fluorouracil

Propoxyphene

ACE inhibitors

Phenytoin

Altretamine

Disease interactions

Angioedema

This medicine should be administered with caution in patients who have a history of or are at risk of developing swellings of the inner layers of the skin. These swellings can cause airway blockage and prove life-threatening. An alternative treatment option should be considered based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as prescribed by the doctor. Do not take this medicine in larger or smaller quantities than recommended. You are advised to continue taking this medicine for the recommended period of time. The dose to be taken is likely to be changed based on the therapeutic response and clinical condition. Inform the doctor if symptoms do not improve after using it or any unwanted side effects like vision disturbance are experienced. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Alpha lipoic acid slows down cellular damage and helps to restore levels of essential vitamins such as vitamin E and vitamin C. Folic acid and Pyridoxine are essential for the production of certain vital components that are necessary for the maintenance of normal body functions. Methylcobalamin works by facilitating the enzymes responsible for the production of vital components and energy inside a cell. Pregabalin acts by reducing certain chemical transmitters in the brain and slowing down nerve impulses. Thus, this combination is better effective for treating painful diabetic neuropathy.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Gamma-aminobutyric acid analogs, Vitamins

Schedule

Schedule H

Lipoic Acid - DrugBank [Internet]. Drugbank.ca. 2017 [cited 18 October 2017]. Available from:

https://www.drugbank.ca/drugs/DB00166

Folic Acid - DrugBank [Internet]. Drugbank.ca. 2017 [cited 30 May 2017]. Available from:

https://www.drugbank.ca/drugs/DB00158

Methylcobalamin hydrate | C63H93CoN13O15P - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 9 March 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/91886214#section=Top

Pregabalin | C8H17NO2 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 7 April 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/5486971

Pyridoxine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 16 March 2018]. Available from:

https://www.drugbank.ca/drugs/DB00165
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Information on this page was last updated on 21 Dec 2018

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