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Pregalex-NT Tablet
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Pregalex-NT Tablet

Manufactured bySolvate Laboratories Pvt. Ltd.
ContainsPregabalin (75 mg) + Nortriptyline (10 mg)
Description
Pregalex-NT Tablet is a combination of Pregabalin and Nortriptyline. It is used in the treatment of pain caused due to damaged nerves. It relieves pain by decreasing certain chemical substances that send pain signals throughout your body. Pregalex-NT Tablet shows side effects like nausea, dry mouth, difficulty in urination, weight gain, constipation, weakness, confusion, etc. Consult your doctor if these symptoms persist or become severe. You can manage weight gain with regular exercise. Avoid driving or operating heavy machines as this medicine may cause drowsiness. Pregalex-NT Tablet may be taken with or without food. Take it at the same time every day for better results. Your doctor will determine the dose and duration of this medication based on your clinical condition. Never take more than the prescribed dose. Avoid the discontinuation of this medicine without consulting your doctor as it may lead to withdrawal symptoms like headache, mood swings, irritation, etc. Pregalex-NT Tablet is not recommended for use if your allergic to it. Inform your doctor if you have kidney, liver, or heart problems. Pregalex-NT Tablet is not recommended for use in children below 18 years of age as there is no safety and efficacy data established. Consult your doctor if you are pregnant, or are breastfeeding.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Pregalex-NT Tablet

  • Difficulty in breathing
  • Chest tightness
  • Swelling of face, lips, eyelids, tongue
  • Tiredness and weakness
  • Blurred vision
  • Dizziness
  • Dry mouth
  • Headache
  • Loss of coordination
  • Loss of bladder control
  • Decreased interest in sexual intercourse
  • Difficulty in urination
  • Nausea
  • Weight gain
  • Swelling in the hands or feet
  • Confusion
  • Drowsiness

Uses of Pregalex-NT Tablet

What is it prescribed for?

  • Neuropathic pain
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The time taken for Pregalex-NT Tablet to show its action is not known.
  • How long do the effects of this medicine last?
    The amount of time for which Pregalex-NT Tablet remains effective in your body is unknown.
  • Is it safe to consume alcohol while taking this medicine?
    Avoid consumption of alcohol if you are taking Pregalex-NT Tablet. It may increase the risk of side effects like dizziness, drowsiness, and impaired ability to think. Avoid performing any activities that require high mental alertness like driving or operating machines.
  • Is this a habit forming medicine?
    Pregalex-NT Tablet has a low abuse potential with limited physical and psychological dependence.
  • Can this medicine be taken during pregnancy?
    Pregalex-NT Tablet is not recommended during pregnancy. Consult your doctor if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    Pregalex-NT Tablet is not recommended while breastfeeding as it may pass into breastmilk. Consult your doctor if you are breastfeeding.

Allergy

Avoid taking Pregalex-NT Tablet if you have been allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulty, etc.

Myocardial infarction

Myocardial Infarction or heart attack is caused due to reduced and/or improper supply of oxygen to your heart. Avoid taking Pregalex-NT Tablet if you are recovering from a heart attack as this medicine may worsen your health condition. Inform your doctor about your recent health problems before taking this medication.

Monoamine oxidase inhibitors (MAO)

Monoamine oxidase inhibitors are medicines used in the treatment of depression. Pregalex-NT Tablet is not recommended if you are taking monoamine oxidase inhibitors as it increases the risk of side effects. A time gap of at least 14 days should be maintained between stopping treatment with MAOIs and starting treatment with this medicine.
Warnings for special population

Pregnancy

Pregalex-NT Tablet is not recommended during pregnancy. Consult your doctor if you are pregnant.

Breast-feeding

Pregalex-NT Tablet is not recommended while breastfeeding as it may pass into breastmilk. Consult your doctor if you are breastfeeding.
General warnings

Kidney disease

Pregalex-NT Tablet should be used with caution if you have kidney problems as this medicine is excreted via the urine. Your doctor will closely monitor your kidney function while taking this medicine. Your doctor may recommend dose adjustment or an alternative medicine based on your clinical condition.

Suicidal tendencies

Pregalex-NT Tablet should be used with caution as it can cause suicidal thoughts, especially if you have displayed such tendencies in your past. Hence, close observation for any change in mood or behaviour is necessary while taking Pregalex-NT Tablet. Inform your doctor if you experience any symptoms.

Driving or operating machines

Pregalex-NT Tablet may increase the risk of drowsiness, dizziness, difficulty in concentrating, etc. Hence, avoid performing any activities such as driving vehicles or operating machines if you experience any of these symptoms.

Withdrawal symptoms

Sudden discontinuation of Pregalex-NT Tablet may lead to withdrawal symptoms such as irritability, mood swings, depression, nervousness, etc. Do not stop the use of this medicine without consulting your doctor.

Use in Children

Pregalex-NT Tablet is not recommended for use in children below 18 years of age since the safety and efficacy data are not clinically established.

Surgery

If anaesthesia is given during treatment with Pregalex-NT Tablet, it may increase the risk of side effects like low blood pressure and irregular heart rhythm. Hence, inform your doctor about the use of this medicine before undergoing any surgery.

Liver diseases

Pregalex-NT Tablet should be used with caution if you have liver problems as it may lead to undesired effects. Your doctor will closely monitor your liver functions while taking this medicine and/or recommend dose adjustments based on your clinical condition.

Potential for abuse

Pregalex-NT Tablet may cause dependency, especially if you have used other recreational medicines in the past. Inform your doctor if you have a history of substance abuse before taking this medicine. Your doctor may prescribe a suitable alternative.

High creatinine kinase levels

Myopathy is a condition in which the muscles do not function properly leading to muscle weakness. Pregalex-NT Tablet should be used with caution in such conditions as this medicine causes an increase in the creatine kinase levels which may worsen your condition.

Missed Dose

Take the missed dose of Pregalex-NT Tablet as soon as you remember. If it is time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Never take more than the prescribed dose. Seek emergency medical treatment if you suspect an overdose of Pregalex-NT Tablet .
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Avoid consumption of alcohol if you are taking Pregalex-NT Tablet. It may increase the risk of side effects like dizziness, drowsiness, and impaired ability to think. Avoid performing any activities that require high mental alertness like driving or operating machines.
Interaction with Medicine

Linezolid

Lorazepam

Ondansetron

Buprenorphine

Metoprolol

Oxycodone

Propoxyphene

Pioglitazone

Ramipril

Disease interactions

Angioedema

Angioedema is the swelling of the inner layers of your skin. Pregalex-NT Tablet should be used with caution if you have a known history of angioedema. This medicine may further increase the risk of angioedema.

Heart Disease

Pregalex-NT Tablet should be used with caution if you have heart problems as this medicine may alter blood pressure and heart rate. It may also increase the risk of heart attack and stroke. Your doctor may suggest tests to monitor the functioning of your heart.

Diabetes Mellitus

Pregalex-NT Tablet should be used with caution if you have Diabetes as this medicine may alter blood sugar levels. Your doctor may recommend regular monitoring of your blood sugar levels while taking this medicine.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Pregalex-NT Tablet may be taken with or without food. Do not crush, chew or break the tablet. Take this medicine exactly as advised by your doctor for the recommended duration. Avoid taking larger or smaller quantities than recommended. Take this medicine at the same time every day for the ease of remembering. Inform your doctor if your symptoms do not improve or if you experience any side effects. Avoid the consumption of alcohol as it may lead to undesired effects.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
Pregalex-NT Tablet is a combination of Pregabalin and Nortriptyline. Pregabalin works by reducing the levels of certain chemical transmitters in your brain and slowing down nerve impulses. Nortriptyline works by increasing the amount of a chemical substance in your brain which helps to inhibit the pain signals.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Gamma-aminobutyric acid analogs, Tricyclic antidepressants

Schedule

Schedule H

Drugs, H., 2021. Pregabalin: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 24 June 2021].

https://medlineplus.gov/druginfo/meds/a605045.html>

Medicines.org.uk. 2021. Nortriptyline 10 mg Film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 24 June 2021].

https://www.medicines.org.uk/emc/medicine/32962>

Drugs, H., 2021. Nortriptyline: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 24 June 2021].

https://medlineplus.gov/druginfo/meds/a682620.html>

Medicines.org.uk. 2021. Pregabalin 150 mg capsules, hard - Summary of Product Characteristics (SmPC) - (emc). [online] Available at: < [Accessed 25 August 2021].

https://www.medicines.org.uk/emc/product/7132/smpc#PRODUCTINFO>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 24 August 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/209501s000lbl.pdf>
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Information on this page was last updated on 10 Nov 2021

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