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Pregadoc NT Tablet

Manufactured byLupin Ltd.
ContainsPregabalin (75 mg) + Nortriptyline (10 mg)
Description

Pregadoc NT Tablet is a combination medicine which may be used for the treatment of neuropathic disorders including neuropathic pain due to diabetic neuropathy, postherpetic neuralgia, etc. It may also be used to treat certain types of anxiety disorders, certain types of seizures, fibromyalgia (severe muscle pain and tenderness with altered mood and sleep cycles). This medicine is not recommended for use in children less than 18 years of age.

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Side effects

Major & minor side effects for Pregadoc NT Tablet

  • Difficulty in breathing
  • Chest tightness
  • Chills
  • Severe diarrhea
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Unusual tiredness and weakness
  • Blurred or double vision
  • Dizziness
  • Dry mouth
  • Headache
  • Memory problem
  • Loss of coordination
  • Fever
  • Loss of appetite
  • Slurred speech
  • Loss of bladder control
  • Burning, numbness, tingling in the arms and feet
  • Weakness in arms, hands, legs or feet
  • Decreased interest in sexual intercourse
  • Black tongue
  • Breast enlargement
  • Skin rash

Uses of Pregadoc NT Tablet

What is it prescribed for?

  • Diabetic Neuropathy
  • Postherpetic Neuralgia
  • Fibromyalgia
  • Peripheral Neuropathy
  • Generalized anxiety disorder
  • Epilepsy
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time taken by this medicine to show its effect is subject to vary based on the individual constitution and intended use.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains effective is subject to vary based on the individual constitution and intended use.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended while taking this medicine since the combination increases the risk of side effects like dizziness, blurred vision, sweating, and muscle stiffness. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    This medicine has a low abuse potential with limited physical and psychological dependence.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to pregabalin, nortriptyline, or any other inactive ingredients present along with these medicines.

Heart attack

This medicine is not recommended for use if the patient is recovering from a recent heart attack.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Kidney disease and dialysis

This medicine should be administered with caution in patients with an impaired kidney function. Close monitoring of kidney function is recommended while using this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Suicidal tendencies

This medicine may cause suicidal ideation in some patients. Hence, it should be used with caution, especially in patients who have had such tendencies in past and in patients with a history of psychological disorders. Close monitoring of mood and behavior is recommended for these patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the patient's clinical condition.

Driving or operating machinery

This medicine may increase the risk of drowsiness, dizziness, difficulty in concentrating, etc. in some patients. Hence, it is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Withdrawal symptoms

Use of this medicine should not be stopped abruptly, especially when used for epilepsy. The risk of adverse effects is high if it is withdrawn suddenly. Do not stop the use of this medicine without consulting your doctor.

Edema

This medicine can cause fluid retention in the body and hence should be used with caution in patients suffering from any fluid retention disorders. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Heart block

This medicine can cause heart rhythm abnormalities which could result in blockage and associated complications. Hence, it should be used with caution in patients having diseases of the heart and the blood vessels. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Use in Children

This medicine is not recommended for use in patients less than 18 years of age since the safety and effectiveness of use are not clinically established.

Surgery

Use of this medicine is not recommended if you are planning to undergo a surgery in the near future. Consult your doctor in this regard, so that therapy with this medicine can be discontinued appropriately.

Bipolar disorder

This medicine is not recommended for use in patients suffering from a bipolar disorder since the symptoms of mania and depression may worsen upon usage of this medicine. Report any history of bipolar depression or mania to the doctor before receiving this medicine.

Liver diseases

This medicine should be administered with caution in patients with an impaired liver function. Close monitoring of liver function is recommended while using this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Potential for abuse

This medicine may cause dependence, especially in patients who are chronic alcohol users or have used other recreational drugs in the past. Report the past use of alcohol or other drugs to the doctor before receiving this medicine.

Rhabdomyolysis

This medicine has been associated with rare cases of muscle breakdown disorders that affect kidneys. You should report any instance of muscle pain, weakness, the presence of dark reddish coloration of urine, etc. to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while taking this medicine since the combination increases the risk of side effects like dizziness, blurred vision, sweating, and muscle stiffness. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Glimepiride

Linezolid

Lorazepam

Ondansetron

Buprenorphine

Metoprolol

Oxycodone

Propoxyphene

ACE inhibitors

Disease interactions

Angioedema

This medicine should be used with caution in patients with a known history of angioedema or at risk of developing swellings of the inner layers of the skin. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Heart Disease

This medicine should be used with caution in patients suffering from heart diseases like heart failure, stroke, heart block, etc. A fall in the blood pressure, change in pulse, dizziness, and other associated complications should be reported to the doctor on priority. This medicine is not recommended for use in patients who have recently suffered a heart attack.

Pheochromocytoma

This medicine should be used with extreme caution in patients suffering from Pheochromocytoma. The risk of severe to fatal change in blood pressure is very high in such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Seizure disorders

This medicine should be used with caution in patients with seizure disorder since using this medicine may cause more frequent and severe episodes of seizures. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Diabetes Mellitus

This medicine should be used with caution in patients with diabetes since the risks of changes in blood sugar levels are very high. Close monitoring of blood glucose levels is recommended while using this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as instructed by your doctor. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor since an abrupt withdrawal of therapy may cause severe withdrawal symptoms.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
Pregabalin works by reducing the levels of certain chemical transmitters in the brain and slowing down nerve impulses. Nortriptyline works by increasing the amount of a chemical substance in the brain which helps in maintaining the mental balance.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Gamma-aminobutyric acid analogs, Tricyclic antidepressants

Schedule

Schedule H

Pregabalin: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 7 April 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a605045.html

[Internet]. 2017 [cited 25 July 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/32962

Nortriptyline: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 25 July 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682620.html

Pregabalin | C8H17NO2 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 7 April 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/5486971

[Internet]. Larenon.com. 2018 [cited 6 December 2018]. Available from:

http://www.larenon.com/wp-content/uploads/2015/08/pbren_m_nt_ctc2.pdf
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Information on this page was last updated on 6 Dec 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.