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Pregabid-D 50 Capsule

Manufactured byINTAS PHARMACEUTICALS LTD
ContainsPregabalin (50 mg) + Duloxetine (10 mg)
Description

Pregabid-D 50 Capsule is a combination medicine which may be used for the treatment of neuropathic disorders such as neuropathic pain due to diabetic neuropathy, peripheral neuropathy, postherpetic neuralgia, etc. It may also be used to treat certain types of anxiety disorders and fibromyalgia (severe muscle pain and tenderness with altered mood and sleep cycles). This medicine is not recommended for use in patients below 18 years of age.

Side effects

Major & minor side effects for Pregabid-D 50 Capsule

  • Nausea
  • Dry mouth
  • Body pain
  • Abnormal ejaculation
  • Loose stools
  • Shaking of hands or feet
  • Heartburn
  • Difficulty in breathing
  • Chest tightness
  • Chills
  • Severe diarrhea
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Unusual tiredness and weakness
  • Blurred or double vision
  • Dizziness
  • Headache
  • Memory problem
  • Fever
  • Anxiety and nervousness
  • Slurred speech

Uses of Pregabid-D 50 Capsule

What is it prescribed for?

  • Generalized anxiety disorder
  • Diabetic Neoropathy
  • Fibromyalgia
  • Postherpetic Neuralgia
  • Peripheral Neuropathy
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time taken by this medicine to show its effect is subject to vary based on the individual constitution and intended use.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 24 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended while taking this medicine since the combination increases the risk of side effects like dizziness, blurred vision, sweating, and muscle stiffness. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    This medicine may cause low abuse potential with limited physical and psychological dependence.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to pregabalin, duloxetine, or any other inactive ingredients present in the formulation.

Monoamine oxidase inhibitors

This medicine is not recommended for use in patients taking monoamine oxidase inhibitors (MAOI) due to the increased risk of serious and life-threatening side effects. A time gap of at least 14 days should be maintained between stopping therapy with MAOIs and starting therapy with this medicine.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women except in life-threatening conditions. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Suicidal thoughts

Use of this medicine may cause suicidal ideation in some patients. Hence, it should be used with caution, especially in patients who have had such tendencies in the past and in patients with a history of psychological disorders. Close monitoring of mood and behavior is recommended for these patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Orthostatic Hypotension and fall

Use of this medicine is known to cause orthostatic hypotension especially during the 1st week of the treatment. This effect can increase the risk of fall in the elderly population. Any symptoms of dizziness, unsteady walking should be reported to the doctor.

Abnormal bleeding

Use of this medicine may increase the risk of bleeding especially in the patients receiving nonsteroidal anti-inflammatory drugs, aspirin, and warfarin. Monitoring of blood cells count should be performed. Any symptoms of abnormal bleeding should be reported to the doctor on priority.

Low sodium levels

Use of this medicine is known to lower the sodium levels in the body. This risk is more in the elderly population and in the patients receiving diuretics. Monitoring of sodium levels should be performed. Any symptoms of unsteadiness, headache, difficulty in concentration should be reported to the doctor.

Withdrawal symptoms

Use of this medicine should not be stopped abruptly as the risk of adverse effects is high if it is withdrawn suddenly. Do not stop the use of this medicine without consulting your doctor.

Liver diseases

This medicine should be administered with caution in patients with an impaired liver function. Close monitoring of liver function is recommended while using this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney disease and dialysis

This medicine should be administered with caution in patients with an impaired kidney function. It is not recommended for use in patients with severe kidney injury (CrCl less than 30 ml/min). Close monitoring of kidney function is recommended while using this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or operating machinery

Use of this medicine may increase the risk of drowsiness, dizziness, difficulty in concentrating, etc. in some patients. Hence, it is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Edema

Use of this medicine can cause fluid retention in the body and hence should be used with caution in patients suffering from any fluid retention disorders. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Heart block

Use of this medicine can cause heart rhythm abnormalities which could result in blockage and associated complications. Hence, it should be used with caution in patients having diseases of the heart and the blood vessels. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

High creatinine kinase levels

This medicine should be used with caution in patients having a blood clotting disorder or high levels of creatinine kinase levels in the blood due to the increased risk of adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Use in Children

This medicine is not recommended for use in patients less than 18 years of age since the safety and effectiveness of use are not clinically established.

Potential for abuse

Use of this medicine may cause dependence, especially in patients who are chronic alcohol users or have used other recreational drugs in the past. Report the past use of alcohol or other drugs to the doctor before receiving this medicine.

Rhabdomyolysis

Use of this medicine has been associated with rare cases of muscle breakdown disorders that affect kidneys. You should report any instance of muscle pain, weakness, the presence of dark reddish coloration of urine, etc. to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while taking this medicine since the combination increases the risk of side effects like dizziness, blurred vision, sweating, and muscle stiffness. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Ciprofloxacin

Lorazepam

Buprenorphine

Oxycodone

Propoxyphene

Hypoglycemic agents

ACE inhibitors

Disease interactions

Diabetes

This medicine should be used with caution in patients with diabetes since the risks of changes in blood sugar levels are very high. Close monitoring of blood glucose levels is recommended while using this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Glaucoma

This medicine should be used with caution in patients with glaucoma due to the risk of increased fluid pressure in the eye. Inform the doctor if you have any history of eye disorder. Suitable dose adjustments or an alternate medicine should be considered based on the clinical condition.

Angioedema

This medicine should be used with caution in patients with a known history of angioedema or at risk of developing swellings of the inner layers of the skin. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as instructed by your doctor. Do not take in larger amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor since an abrupt withdrawal of therapy may cause severe withdrawal symptoms.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
Pregabalin works by reducing the levels of certain chemical transmitters in the brain and slowing down nerve impulses. Duloxetine works by increasing the levels of certain chemical substances in the brain and thus helps in maintaining mental balance and also stops the pain signaling to the brain.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Gamma-aminobutyric acid analogs, Serotonin-norepinephrine reuptake inhibitors

Schedule

Schedule H

DailyMed - PREGABALIN- pregabalin capsule [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 7 April 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=54e6d137-a495-4b87-b3c2-2f5a0226dd3e

Pregabalin | C8H17NO2 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 7 April 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/5486971

Pregabalin | Side Effects, Dosage, Uses & More [Internet]. Healthline.com. 2017 [cited 7 April 2017]. Available from:

http://www.healthline.com/drugs/pregabalin/oral-capsule#Highlights1

Duloxetine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 11 April 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a604030.html#

DailyMed - Duloxetine hydrochloride capsule, delayed release [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 11 April 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0a541d20-5466-433b-a104-40a7b2296076#Section_14.4
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Information on this page was last updated on 21 May 2019

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