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Pregabid-D 50 Capsule
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Pregabid-D 50 Capsule

Manufactured byINTAS PHARMACEUTICALS LTD
ContainsPregabalin (50 mg) + Duloxetine (10 mg)
Description
Pregabid-D 50 Capsule is a combination of Pregabalin and Duloxetine. It is used in the treatment of pain caused due to damaged nerves. It relieves pain by decreasing certain chemicals substances that send pain signals throughout your body. Pregabid-D 50 Capsule may cause side effects like are nausea, dry mouth, swelling in your hands or feet, weight gain, weakness, confusion, etc. These symptoms may subside by themselves. However, consult your doctor if they bother you. Avoid driving or operating heavy machines as it may cause drowsiness. Pregabid-D 50 Capsule may be taken with or without food. Take it at the same time every day for better results. Your doctor will determine the dosage and duration of this medication based on your condition. Never take more than the prescribed dose. Avoid the discontinuation of this medicine without consulting your doctor as it may lead to withdrawal symptoms like headache, mood swings, irritation, etc. Pregabid-D 50 Capsule is not recommended if your allergic to it. Inform your doctor if you have any kidney, liver, or heart problems. It is not recommended for use in children below 18 years of age as there is no safety and efficacy data established. Consult your doctor if you are pregnant or are breastfeeding.
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Side effectsConcernsUsage

Side effects

Major & minor side effects for Pregabid-D 50 Capsule

  • Nausea
  • Dry mouth
  • Body pain
  • Abnormal ejaculation
  • Diarrhoea
  • Shaking of hands or feet
  • Difficulty in breathing
  • Chest tightness
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Tiredness and weakness
  • Blurred vision
  • Drowsiness
  • Headache
  • Weight gain
  • Confusion
  • Increased sweating
  • Constipation

Uses of Pregabid-D 50 Capsule

What is it prescribed for?

  • Neuropathic pain
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time taken by Pregabid-D 50 Capsule may start its action in 2 hours.
  • How long do the effects of this medicine last?
    It is not known how long Pregabid-D 50 Capsule remains active in the body.
  • Is it safe to consume alcohol while taking this medicine?
    Avoid consumption of alcohol if you are taking Pregabid-D 50 Capsule. It may increase the risk of side effects like dizziness, drowsiness, and impaired ability to think. Avoid performing any activities that require high mental alertness like driving or operating machines.
  • Is this a habit forming medicine?
    Pregabid-D 50 Capsule may cause low abuse potential with limited physical and psychological dependence.
  • Can this medicine be taken during pregnancy?
    Pregabid-D 50 Capsule is not recommended during pregnancy unless absolutely necessary. Consult your doctor if you are pregnant.
  • Can this medicine be taken while breast-feeding?
    Pregabid-D 50 Capsule is not recommended while breastfeeding as it may pass into breastmilk. Consult your doctor if you are breastfeeding.

Allergy

Avoid taking Pregabid-D 50 Capsule if you are previously allergic to it. Seek immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulties, etc.

Monoamine oxidase inhibitors

Avoid taking Pregabid-D 50 Capsule if you are using monoamine oxidase inhibitors (MAOI) (depression tablets) due to the increased risk of serious and life-threatening side effects. A time gap of at least 14 days should be maintained between stopping therapy with MAOIs and starting therapy with this medicine.

Liver Disease

Pregabid-D 50 Capsule is not recommended if you have liver problems as it may worsen your condition.
Warnings for special population

Pregnancy

Pregabid-D 50 Capsule is not recommended during pregnancy unless absolutely necessary. Consult your doctor if you are pregnant.

Breast-feeding

Pregabid-D 50 Capsule is not recommended while breastfeeding as it may pass into breastmilk. Consult your doctor if you are breastfeeding.
General warnings

Abnormal bleeding

Pregabid-D 50 Capsule may increase the risk of bleeding especially if you are taking nonsteroidal anti-inflammatory drugs, Aspirin, or Warfarin. You should report any symptoms of abnormal bleeding to your doctor on priority.

Low sodium levels

Pregabid-D 50 Capsule should be used with caution if you have lower sodium levels in your body. This risk is higher in the elderly population or if you are taking Diuretics (medicine that increases excretion of sodium and water via urine). Your doctor may regularly monitor sodium levels in your body. If you experience any unusual symptoms, consult your doctor.

Withdrawal symptoms

Abrupt discontinuation of Pregabid-D 50 Capsule may lead to the increased risk of withdrawal symptoms such as irritability, mood swings, depression, nervousness, etc. Do not stop the use of this medicine without consulting your doctor.

Kidney disease

You should use Pregabid-D 50 Capsule should be used with caution if you have kidney problems. It is not recommended if you have severe kidney problems (CrCl less than 30 ml/min). Your kidney function has to be monitored regularly. Your doctor may recommend an appropriate dose adjustment or alternative medicine based on your clinical condition.

Driving or operating machines

Pregabid-D 50 Capsule may increase the risk of drowsiness, dizziness, difficulty in concentrating, etc. Hence, you should not perform any activities such as driving or operating machines if you experience any of the symptoms.

Heart disease

Pregabid-D 50 Capsule should be used with caution if you have heart problems as it causes abnormal heart rhythm which could result in further complications. This medicine may also cause retention of fluid in your body and increase the risk of heart failure. It is more likely to occur in elderly people with compromised heart function. Your doctor will closely monitor the functioning of your heart.

Use in Children

Pregabid-D 50 Capsule is not recommended for use in children and adolescents below 18 years of age since the safety and efficacy of this medicine is not clinically established.

Potential for abuse

Pregabid-D 50 Capsule may cause dependency, especially if you have used other recreational medicines in the past. Inform your doctor if you have a history of substance abuse before receiving this medicine. Your doctor may prescribe a suitable alternative.

High creatinine kinase levels

Myopathy is a condition in which the muscles do not function properly leading to muscle weakness. Use Pregabid-D 50 Capsule with caution in such conditions as this medicine causes an increase in the creatine kinase levels which may worsen your condition.

Suicidal tendencies

Use Pregabid-D 50 Capsule with caution as it can cause suicidal thoughts. Close monitoring of mood and behaviour is recommended. Inform your doctor if you experience any symptoms.

Missed Dose

Take the missed dose of Pregabid-D 50 Capsule as soon as you remember. If it is time for your next scheduled dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Never take more than the prescribed dose of Pregabid-D 50 Capsule. Seek emergency medical attention or contact your doctor in case of an overdose for further guidance.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Avoid consumption of alcohol if you are taking Pregabid-D 50 Capsule. It may increase the risk of side effects like dizziness, drowsiness, and impaired ability to think. Avoid performing any activities that require high mental alertness like driving or operating machines.
Interaction with Medicine

Ciprofloxacin

Lorazepam

Pioglitazone

Ramipril

Disease interactions

Diabetes

Pregabid-D 50 Capsule should be used with caution if you have Diabetes as this medicine may alter blood sugar levels. Regular monitoring of blood sugar levels is recommended while using this medicine. Your doctor may prescribe an alternative based on your clinical condition.

Glaucoma

Glaucoma is a condition of increased fluid retention inside your eyes which may lead to blurred vision or blindness. Pregabid-D 50 Capsule with caution if you have glaucoma due to the risk of worsening of your condition. Your doctor may adjust the dose or prescribe an alternative based on your clinical condition.

Angioedema

Angioedema is swellings of the inner layers of your skin. Pregabid-D 50 Capsule should be used with caution if you have a known history of angioedema. This medicine may further increase the risk of angioedema.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
Pregabid-D 50 Capsule may be taken with or without food as instructed by your doctor. Do not chew or break the capsule in your mouth. Take this medicine exactly as advised by your doctor for the prescribed duration. Avoid taking larger or smaller quantities than recommended. Take this medicine at the same time every day for the ease of remembering. Inform your doctor if your symptoms do not improve or if you experience any side effects. Avoid the consumption of alcohol as it may lead to undesired effects.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
Pregabid-D 50 Capsule is a combination of Pregabalin and Duloxetine. Pregabalin works by reducing the levels of certain chemical transmitters in your brain and slowing down nerve impulses. Duloxetine works by increasing the levels of certain chemical substances in your brain. Thus, it stops the transmission of pain signals in the brain.
Legal Status

Unknown

Unknown

Unknown

Unknown

Classification

Category

Gamma-aminobutyric acid analogs, Serotonin-norepinephrine reuptake inhibitors

Schedule

Schedule H

DailyMed - PREGABALIN- pregabalin capsule [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 7 April 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=54e6d137-a495-4b87-b3c2-2f5a0226dd3e

Pregabalin | C8H17NO2 - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 7 April 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/5486971

Pregabalin | Side Effects, Dosage, Uses & More [Internet]. Healthline.com. 2017 [cited 7 April 2017]. Available from:

http://www.healthline.com/drugs/pregabalin/oral-capsule#Highlights1

Duloxetine: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 11 April 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a604030.html#

DailyMed - Duloxetine hydrochloride capsule, delayed release [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 11 April 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0a541d20-5466-433b-a104-40a7b2296076#Section_14.4
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Information on this page was last updated on 1 Sep 2021

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