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Polycap Capsule

Manufactured byCADILA PHARMACEUTICALS LTD
ContainsAspirin (100 mg) + Simvastatin (20 mg) + Ramipril (5 mg) + Atenolol (50 mg) + Hydrochlorothiazide (12.5 mg)
Description

Polycap Capsule is a combination medicine which is used for the secondary prevention of coronary heart disease and stroke. Patients are advised to maintain an appropriate diet and exercise regimen along with this medicine to get the best possible effect.

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Side effects

Major & minor side effects for Polycap Capsule

  • Abdominal pain
  • Heartburn
  • Constipation
  • Yellow colored eyes or skin
  • Skin rash
  • Irregular heartbeat
  • Acid or sour stomach
  • Drowsiness
  • Irritability
  • Blurred vision
  • Sweating
  • Dizziness
  • Unusual tiredness and weakness
  • Back pain
  • Chest tightness
  • Cough
  • Diarrhea
  • Vomiting
  • Difficulty in breathing
  • Cold hands or feet
  • Anxiety
  • Chest pain
  • Increased thirst
  • Loss of appetite
  • Dark colored urine
  • Headache
  • Excessive air or gas in stomach
  • Increased urination
  • Itching or rash
  • Dry mouth

Uses of Polycap Capsule

What is it prescribed for?

  • Prevention of Coronary heart disease
  • Prevention of Stroke
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 5 to 30 minutes of administration of the dose.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 2 to 3 days.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to aspirin, simvastatin, ramipril, any other ACE inhibitors, atenolol, any other beta-blockers, hydrochlorothiazide, or any other inactive ingredients present along with the formulation.

Aliskiren

Coadministration of aliskiren and this medicine is not recommended due to the increased risk of serious adverse effects. This risk is especially higher in the elderly population and in patients with diabetes and kidney diseases.

Cardiogenic shock

This medicine is not recommended for use in patients suffering from a cardiogenic shock due to the increased risk of worsening of the patient's condition.

Heart block greater than first degree

This medicine is not recommended for use in patients with a heart block greater than the first degree due to the increased risk of worsening of the patient's condition.

Sinus Bradycardia

This medicine is not recommended for use in patients with a known history of sinus bradycardia since it may worsen the patient's condition.

Uncompensated cardiac failure

This medicine is not recommended for use in patients with a known history of an uncompensated cardiac failure due to the increased risk of worsening of the patient's condition.

Severe pulmonary edema

This medicine is not recommended for use in patients with a known history of severe pulmonary edema since it may worsen the patient's condition.

Severe liver impairment

This medicine is not recommended for use in patients with a known history of severe liver diseases due to the increased risk of worsening of the patient's condition.

Anuria

This medicine is not recommended for use in patients with a condition called anuria (a condition where the kidney is unable to produce urine).

Bleeding disorder

This medicine is not recommended for use in patients with a known history of peptic ulcer disease or any other bleeding disorder due to the increased risk of worsening of the patient's condition.

Severe kidney impairment

This medicine is not recommended for use in patients with severe kidney impairment due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Gastrointestinal bleeding

This medicine is not recommended for use in patients with gastrointestinal disorders such as peptic ulcer disease due to the increased risk of excessive bleeding. Replacement with a suitable alternative should be considered based on the clinical condition.

Asthma

This medicine is not recommended for use in patients with a known history of asthma due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative should be considered under your doctor's supervision.

Hypotension

Symptomatic hypotension may occur in patients with volume depletion and patients who are treated with high-dose diuretics. These conditions should be corrected before beginning treatment with this medicine.

Hyperkalemia

This medicine may increase potassium levels in the blood (hyperkalemia). This may cause serious side effects such as fatal cardiac rhythm irregularities. It is advised to avoid potassium-rich foods (potatoes, bananas) and other medicines that may increase potassium levels (potassium-sparing diuretics and potassium supplements) during treatment with this medicine.

Liver dysfunction

This medicine should be used with extreme caution in patients with liver dysfunction due to an increase in the risk of serious adverse effects including coma. Close monitoring of liver function is advised while taking this medicine. Report any symptoms of confusion or jaundice to the doctor on priority. Replacement with a suitable alternative may be necessary based on the clinical condition.

Use in children

This medicine is not recommended for use in children since the safety and efficacy of use are not clinically established.

Cough

This medicine may cause a persistent nonproductive cough in some patients. It is resolved when the medicine is discontinued.

Cardiac Failure

This medicine can cause heart failure and reduced blood flow in patients having a heart disease. Close monitoring of heart function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Major surgery

This medicine should be used with caution in patients who are scheduled to undergo major surgery. An anesthetic agent with little negative inotropic activity should be selected to minimize the effect on the heart.

Lung Diseases

This medicine should be used with extreme caution in patients with lung diseases due to the increased risk of serious adverse effects. Close monitoring of lung function is recommended for such patients. Replacement with a suitable alternative may be required in some cases based on the clinical condition.

Hyperlipidemia

This medicine should be used with caution in patients with hyperlipidemia since it may alter the serum lipid profiles. Close monitoring of serum lipid profiles is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition.

Sports

Athletes are advised not to indulge in certain sports while using this medicine. Archery, racing, shooting and other high-risk sports should be avoided. Sportspersons should refer to the list of medicines published by World Anti-Doping Agency (WADA) which are not to be taken while participating in specific sports events.

Hyperthyroidism

This medicine should be administered with caution in patients with increased thyroid hormone levels. Abrupt withdrawal of this medicine may lead to a life-threatening condition called thyroid-storm. Frequent monitoring of thyroid hormone levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Cognitive impairment

This medicine may cause forgetfulness, memory loss, confusion, etc. in some patients. These side effects are reversible and disappear once the medicine is discontinued.

Driving or operating machinery

Use of this medicine may cause symptoms such as dizziness, blurred vision, confusion, drowsiness, etc. in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember it. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of side effects such as dizziness, lightheadedness, and fainting. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Alprazolam

Carbamazepine

Diltiazem

Methotrexate

Corticosteroids

Cyclosporine

Colchicine

Aliskiren

Insulin

Theophylline

Antacids

Antidepressants

Nonsteroidal anti-inflammatory medicines

Disease interactions

Angioedema

This medicine is not recommended for use in patients with a known history of angioedema or a family history of angioedema due to the increased risk of worsening of the patient's condition. Report any symptoms such as swelling of the face, lips, eyes, etc. to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Asthma

This medicine is not recommended for use in patients with a history of asthma due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative should be considered based on the clinical condition.

Bradyarrhythmia/ AV Block

This medicine is not recommended for use in patients with sinus bradyarrhythmia or a heart block greater than the first degree due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative should be considered based on the clinical condition.

Glaucoma

This medicine should be used with caution in patients with glaucoma because it may lower the intraocular pressure and worsen the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Pheochromocytoma

This medicine should be used with caution in patients with a known history of pheochromocytoma due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative should be considered under your doctor's supervision.

Impaired liver function

This medicine should be used with caution in patients with a known history of liver diseases due to the increased risk of worsening of the patient's condition. Close monitoring of liver function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Rhabdomyolysis

This medicine is not recommended for use in patients with rhabdomyolysis since it may worsen the patient's condition. Replacement with a suitable alternative should be considered under your doctor's supervision.

Diabetes

This medicine should be used with caution in patients with diabetes mellitus due to the increased risk of altered blood glucose levels. In some patients, this medicine may also mask the symptoms of hypoglycemia, such as tremors, tachycardia, blood pressure changes, etc. Regular monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition of the patient.

Hyperuricemia

This medicine should be used with caution in patients with a history of gout or chronic kidney failure due to the increased risk of hyperuricemia. Close monitoring of uric acid level is recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with this medicine due to the increased risk of side effects such as tenderness, weakness, dark-colored urine, etc.
Coadministration of multivitamin with minerals and this combination medicine should be avoided since it may decrease the effects of the medicine. A time gap of at least 2 hours should be maintained between the administration of multivitamins with minerals and this combination medicine to avoid their interaction.
Avoid consumption of large amounts of orange juice with this medicine since it may decrease the effectiveness of the medicine.
Lab interactions
Information not available.
Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller quantities than recommended. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Aspirin prevents abnormal blood clotting, relieves inflammation and swelling, and promotes a smooth flow of blood. Simvastatin reduces the production of cholesterol in the body. Ramipril relaxes the blood vessels and promotes the smooth flow of blood. Atenolol relaxes the blood vessels, reduces the heart rate, promotes a smooth flow of blood, and reduces the blood pressure. Hydrochlorothiazide increases the excretion of water and sodium through the urine. Their combination is thus better effective for the prevention of coronary heart disease and stroke.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Angiotensin converting enzyme inhibitors, Cardioselective beta blockers, Thiazide diuretics, Antiplatelet agents, Statins

Schedule

Schedule H

DailyMed - Simvastatin tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 31 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5c1c694c-4b08-469e-b538-08e69df06146

[Internet]. Polycap.org. 2019 [cited 11 January 2019]. Available from:

http://www.polycap.org/

[Internet]. Medlineplus.gov. 2017 [cited 8 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a692027.html

[Internet]. Dailymed.nlm.nih.gov. 2017 [cited 10 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f36d4ed3-dcbb-4465-9fa6-1da811f555e6

[Internet]. 2017 [cited 30 May 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/33364
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Information on this page was last updated on 15 Nov 2019

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