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Plegridy Injection

Manufactured byBIOGEN IDEC INDIA
Description

Plegridy Injection is used for the treatment of relapsing forms of multiple sclerosis (a disease that affects the brain and spinal cord) in adult patients. This medicine is not recommended for use in patients less than 18 years of age.

Side effects

Major & minor side effects for Plegridy Injection

  • Injection site reactions
  • Fever and chills
  • Headache
  • Joint and muscle pain
  • Unusual tiredness or weakness
  • Nausea and vomiting
  • Sweating
  • Hair loss
  • Cough

Uses of Plegridy Injection

What is it prescribed for?

  • Multiple sclerosis
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The amount of time required for this medicine to show its action is not clinically established.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Use of ethanol along with Plegridy Injection may increase the risk of liver damage. Report to your doctor if you experience any signs and symptoms like vomiting, nausea, pale stools, skin rash, itching, loss of appetite, yellowing of skin or eyes, dark urine, etc.
  • Is this a habit forming medicine?
    No habit-forming tendencies were reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to interferon beta or peginterferon or any other inactive ingredients present along with it.

Severe Depression

This medicine is not recommended for use in patients with severe depression and/or suicidal ideation.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Autoimmunity

Use of this medicine can develop different auto-antibodies in the body which may lead to various autoimmune disorders. Close monitoring of symptoms, auto-antibodies, and thyroid stimulating hormones (TSH) levels are recommended.

Bone marrow suppression

Use of this medicine can cause bone marrow depression. Severe decreases in white blood cell or platelet counts have been reported with this medicine. Close monitoring of blood cell count and symptoms for any infections should be monitored. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Severe allergic reactions

This medicine may cause severe allergic reactions. In case of any such reactions, treatment should be discontinued and appropriate medical therapy should be instituted immediately.

Liver impairment

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Psychiatric problems

Use of this medicine can cause life-threatening or fatal neuropsychiatric reactions. These include suicide, suicidal tendency, depression, and an increased risk of relapse of recovering drug addicts. Educate the patients and their caregivers to report any symptoms of depression or suicidal tendency to the doctor so that counseling and monitoring of progress can be performed at regular intervals.

Heart diseases

This medicine should be used with caution in patients with heart dysfunctions such as hypertension, arrhythmias, angina, myocardial infarction, cardiomyopathy, and congestive heart failure due to increased risk of worsening of the patient's condition. Close monitoring of heart function, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Driving or operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low. If you miss any scheduled session, contact your doctor immediately for further instructions.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Use of ethanol along with Plegridy Injection may increase the risk of liver damage. Report to your doctor if you experience any signs and symptoms like vomiting, nausea, pale stools, skin rash, itching, loss of appetite, yellowing of skin or eyes, dark urine, etc.
Interaction with Medicine

Tramadol

Leflunomide

Bupropion

Zidovudine

Natalizumab

Disease interactions

Liver Disease

This medicine should be used with caution in patients with liver dysfunction due to increased risk of worsening of the patient's condition. Close monitoring of liver function, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Autoimmune disorders

This medicine should be used with extreme caution or should be avoided in patients with autoimmune diseases due to increased risk of worsening of the patient's condition. Close monitoring, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Kidney impairment

This medicine should be used with caution in patients with kidney dysfunction due to increased risk of worsening of the patient's condition. Close monitoring of kidney function, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Cardiovascular disease

This medicine should be used with caution in patients with heart dysfunctions such as hypertension, arrhythmias, angina, myocardial infarction, cardiomyopathy, and congestive heart failure due to increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor on priority. Close monitoring of heart function, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Seizures

This medicine should be used with caution in patients with seizure disorders since it may worsen the patient's condition. Report any unusual symptoms to the doctor on priority. Close monitoring of the clinical condition, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine prevents certain immune cells that damage the nerve cells from reaching the brain and spinal cord.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Immunomodulators, Interferons

Schedule

Schedule H

Peginterferon beta-1a - DrugBank [Internet]. Drugbank.ca. 2019 [cited 4 June 2019]. Available from:

https://www.drugbank.ca/drugs/DB09122

Peginterferon Beta-1a Injection: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2019 [cited 4 June 2019]. Available from:

https://medlineplus.gov/druginfo/meds/a614059.html

Plegridy 125 micrograms solution for injection in pre-filled pen - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2019 [cited 4 June 2019]. Available from:

https://www.medicines.org.uk/emc/product/3409/smpc
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Information on this page was last updated on 4 Jun 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.