Piribedil

Description

Piribedil is used to relieve the symptoms of Parkinson's disease. It is effective in improving cognition, memory, and focus in the elderly population. It may also be used to relieve the symptoms of certain specific circulatory disorders of the lower limbs.

Side effects

Major & minor side effects for Piribedil

  • Nausea and Vomiting
  • Flatulence
  • Sleeplessness
  • Sudden sleeping fits
  • Confusion
  • Agitation and anxiety
  • Low blood pressure
  • Severe skin rash and hives
  • Compulsive behaviour
  • Increased libido
  • Dizziness

Uses of Piribedil

What is it prescribed for?

  • Chronic pathological cognitive and neurosensorial deficit
  • Intermittent claudication
  • Parkinson's disease
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains effective in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended while receiving this medicine since it may increase the risk of severe adverse effects.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to piribedil or any other inactive ingredients present in the formulation.

Cardiogenic shock

This medicine is not recommended for use in patients suffering from cardiogenic shock, a condition where the heart is not able to pump blood in sufficient quantities to meet the needs of the body, due to the increased risk of worsening of the patient’s condition.

Acute myocardial infarction

This medicine is not recommended for use in patients who have recently had a heart attack or are exposed to the risk factors of a heart attack due to the increased risk of worsening of the patient’s condition.

Antiemetic Neuroleptics

This medicine is not recommended for use in a combination with any medicine belonging to the antiemetic and neuroleptic class such as prochlorperazine due to the increased risk of worsening of the patient’s condition.

Antipsychotic Neuroleptics

This medicine is not recommended for use in a combination with any medicine belonging to the antipsychotic and neuroleptic class, except clozapine, due to the increased risk of severe adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Other medicines

Piribedil may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Sleep disorders

Use of this medicine may cause marked irregularities in the sleep pattern with sleeplessness and sudden onset of sleep. Patients and caretakers should be warned about this effect as a sudden onset of sleep might happen without awareness or warning signs. Hence, driving vehicles or operating machinery should be avoided during treatment with this medicine.

Risk of falls

This medicine is primarily used by the elderly population where the risk of a fall due to a sudden onset of sleep, confusion, or a sudden fall in blood pressure is significantly high. Patients and caretakers should be educated about the possible risks associated with the use of this medicine. An alternative treatment option may be necessary in some cases based on the clinical condition.

Impulsive behaviour

Use of this medicine may promote impulsive behaviors such as gambling, binge eating, compulsive buying, hypersexuality, etc in some patients. Patients and caretakers should be warned about these effects and the patients should be monitored closely for any change in mood or behavior. An alternative treatment option may be necessary in some cases based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for the next scheduled dose, then the missed dose can be skipped. Contact your doctor if you have missed more than one scheduled dose of this medicine.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended while receiving this medicine since it may increase the risk of severe adverse effects.
Interaction with Medicine

Quetiapine

Risperidone

Pimozide

Bupropion

Aripiprazole

Haloperidol

Metoclopramide

Prochlorperazine

Asenapine

Disease interactions

Alzheimer's disease

This medicine is not recommended for use in patients with Alzheimer's disease, even though certain symptoms such as lack of cognition, memory loss, etc. may be very similar, since it may worsen the patient's condition. An alternative treatment option should be considered in such cases based on the clinical condition.

Dementia

This medicine is not recommended for use in patients with dementia for improvement of cognition and memory due to the increased risk of worsening of the patient’s condition. An alternative treatment option should be considered in such cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as prescribed by the doctor. Do not take it in larger or smaller quantities than recommended. Report any incidence of adverse effects to the doctor. Caretakers should be aware of the risk of falls, compulsive behavior, etc. while the patient is taking this medicine. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken immediately after food

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by increasing the levels of certain specific chemical transmitters in the body.
Legal Status

Approved

Unknown

Unknown

Approved

Classification

Category

Dopamine agonists

Schedule

Schedule H

[Internet]. Servier.com.ve. 2018 [cited 30 August 2018]. Available from:

https://www.servier.com.ve/sites/default/files/spc-pil/spc-trivastal.pdf

[Internet]. Meppo.com. 2018 [cited 30 August 2018]. Available from:

http://www.meppo.com/pdf/drugs/1758-TRIVASTAL-RETARD-1439985549.pdf

Piribedil [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 30 August 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/piribedil#section=Chemical-Vendors

Piribedil - DrugBank [Internet]. Drugbank.ca. 2018 [cited 30 August 2018]. Available from:

https://www.drugbank.ca/drugs/DB12478

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Information on this page was last updated on 7 Jan 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.