Piperaquine

Description

Piperaquine is an antimalarial medicine used in a combination with other medicines for the treatment of uncomplicated malaria infections in adults and children.

Side effects

Major & minor side effects for Piperaquine

  • Nausea
  • Abdominal pain
  • Fatigue
  • Decreased appetite
  • Headache
  • Dizziness
  • Vomiting

Uses of Piperaquine

What is it prescribed for?

  • Malaria
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to piperaquine or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Cardiovascular diseases

This medicine should be used with extreme caution in patients suffering from cardiovascular diseases due to the increased risk of severe adverse effects including an irregular heart rhythm. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Liver impairment

This medicine should be used with caution in patients with liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Kidney impairment

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of renal function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Vomiting

Use of this medicine may cause persistent vomiting in some patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in these cases based on the clinical condition.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not use extra medicine to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Disease interactions

Disease

Information not available.
Food interactions
The absorption of this medicine is increased in the presence of fatty food and this may cause severe adverse effects such as an irregular heart rhythm in some patients. Hence, this medicine should be consumed on an empty stomach.
Lab interactions
Information not available.
Take this medicine exactly as prescribed by the doctor. You are advised to take this medicine on an empty stomach, at least 3 hours before eating food. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It works by increasing the concentration of a substance that inhibits the growth of the malarial parasite.
Legal Status

Approved

Unknown

Unknown

Approved

Classification

Category

Antimalarial agents, 4-Aminoquinolines

Schedule

Schedule H

[Internet]. 2018 [cited 10 April 2018]. Available from:

https://gupea.ub.gu.se/bitstream/2077/7196/1/1.%20Ramber%C3%A4ttelse.pdf

Piperaquine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 10 April 2018]. Available from:

https://www.drugbank.ca/drugs/DB13941

Davis TM e. Piperaquine: a resurgent antimalarial drug. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2018 [cited 10 April 2018]. Available from:

https://www.ncbi.nlm.nih.gov/pubmed/15610051

Patil C. Fixed dose combination of arterolane and piperaquine: A newer prospect in antimalarial therapy. 2018. Available from:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160665/

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Information on this page was last updated on 25 Apr 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.