Piperacillin

Description

Piperacillin is used to treat a variety of conditions such as urinary tract infections, gonococcal infections, pneumonia, intra-abdominal infections, etc. caused by susceptible bacteria.

Side effects

Major & minor side effects for Piperacillin

  • Diarrhea
  • Rash
  • Itching of skin
  • Pain at the injection site
  • Fever
  • Injection site bruising and red coloration
  • Nausea
  • Vomiting

Uses of Piperacillin

What is it prescribed for?

  • Urinary tract infections
  • Community-Acquired Pneumonia
  • Pseudomonas Infections
  • Gynecological infections
  • Gonococcal Infection
  • Intraabdominal Infection
  • Skin and Skin Structure Infection
  • Infection prophylaxis
  • Bacterial infections
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Concerns

Commonly asked questions

  • Onset of action
    The peak effect of this medicine can be observed within 30-50 minutes of an intramuscular administration. On intravenous administration, the effect of this medicine can be observed rapidly.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. If the medicine is used, the infant should be monitored closely for any undesired side effects.

Allergy

This medicine is not recommended for use in patients with a known allergy to piperacillin, other antibiotics of the beta-lactam group, or any other inactive ingredients present along with this medicine.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. If the medicine is used, the infant should be monitored closely for any undesired side effects.
General warnings

Bleeding disorders

This medicine should be administered with extreme caution in patients suffering from bleeding disorders due to the increased risk of worsening of the patient's condition. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Renal Impairment

This medicine should be used with caution in patients suffering from kidney diseases due to the increased risk of severe adverse effects. Regular monitoring of renal function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Drug Resistance

Usage of this medicine without sufficient proof or suspicion of a bacterial infection should be avoided. Irrational dosing might fail in providing the benefits and even cause toxicity. It may also increase the risk of development of bacteria that are drug resistant.

Clostridium difficile-associated Diarrhea

Antibiotic therapy will cause an imbalance in the normal microbial flora of the large intestine, which may promote the growth of a bacteria called Clostridium difficile and you may experience severe diarrhea as a result. Report any such incidence to the doctor on priority and avoid usage of this medicine in such cases.

Skin reactions

This medicine should be used with caution since it may increase the risk of serious skin reactions such as Stevens-Johnson syndrome. Report any unusual symptoms to the doctor on priority. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Intravenous Administration

When used intravenously, this medicine may be infused over a duration of at least 20 to 30 minutes or may be given as a bolus over 3 to 5 minutes to avoid vein irritation.

Missed Dose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of missing a dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Live cholera vaccine

Oxytetracycline

Chloramphenicol

Methotrexate

Doxycycline

Tetracycline

Warfarin

Disease interactions

Renal Dysfunction

This medicine should be used with extreme caution in patients with kidney diseases due to the increased risk of severe adverse effects. Regular monitoring of renal function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Gastrointestinal Diseases

This medicine should be used with extreme caution in patients having a history of gastrointestinal diseases, particularly colitis, since it may worsen the patient's condition. Report any incidence of severe diarrhea, abdominal pain, blood in stools, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Seizures

This medicine should be used with caution in patients suffering from seizure disorders due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor on priority. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional. Inform the doctor if you have a known history of allergy to this medicine. Report to the doctor all your current medicines including any herbs or supplements as well as your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by interfering with certain processes that help the bacteria to grow and increase in number.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antipseudomonal Penicillins

Schedule

Schedule H

Piperacillin [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 8 August 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/piperacillin

Piperacillin - DrugBank [Internet]. Drugbank.ca. 2018 [cited 8 August 2018]. Available from:

https://www.drugbank.ca/drugs/DB00319

TGA eBS - Product and Consumer Medicine Information Licence [Internet]. Ebs.tga.gov.au. 2018 [cited 8 August 2018]. Available from:

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-CMI-01792-3&d=201808071016933

[Internet]. 2018 [cited 8 August 2018]. Available from:

https://www.glowm.com/resources/glowm/cd/pages/drugs/p039.html

DailyMed - Piperacillin sodium injection, powder, lyophilized, for solution [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 8 August 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fac0c875-111e-4af2-d186-ed4d4ee9de59

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Information on this page was last updated on 8 Aug 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.