Pioglitazone

Description

Pioglitazone is an effective medicine to control blood sugar levels in type II Diabetes Mellitus patients. It is to be used along with controlled diet and regular exercise. This medicine may be used in combination with other medicines for effective control.

Side effects

Major & minor side effects for Pioglitazone

  • Hypoglycemia
  • Bloody and cloudy urine
  • Painful urination
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Difficult and painful breathing
  • Irregular heartbeat
  • Weight gain
  • Upper respiratory tract infection
  • Headache
  • Fracture of bones
  • Severe muscle pain
  • Disorder of tooth

Uses of Pioglitazone

What is it prescribed for?

  • Type II Diabetes Mellitus
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Concerns

Commonly asked questions

  • Onset of action
    This medicine has a delayed onset of action owing to its complex mechanism of action. It may take days for the initial action of the medicine to be observed.
  • Duration of effect
    The effect of this medicine lasts for 24 hours after the initial action has begun.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use by women who are pregnant or are planning a pregnancy in the near future. Use of insulin is most preferred during early and mid-stages of pregnancy.
  • Usage while breast-feeding?
    This medicine is not recommended for use in women who are breastfeeding. The risk of adverse effect is very high in infants and hence the potential benefits and risks should be considered before using this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to pioglitazone or any other inactive ingredient present along with this medicine.

Heart Failure

This medicine is not recommended for use if you are suffering from a moderate-to-severe heart failure due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use by women who are pregnant or are planning a pregnancy in the near future. Use of insulin is most preferred during early and mid-stages of pregnancy.

Breast-feeding

This medicine is not recommended for use in women who are breastfeeding. The risk of adverse effect is very high in infants and hence the potential benefits and risks should be considered before using this medicine.
General warnings

Type I diabetes mellitus

This medicine is not recommended for use in patients suffering from type 1 diabetes mellitus since it is not effective in treating this condition.

Heart Failure

This medicine should be used with caution in patients having a mild heart failure. Use of this medication is not recommended if the condition is moderate to severe.

Impaired liver function

This medicine should be used with caution in patients with an impaired liver function due to an increase in the risk of worsening of the patient's condition. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Edema

This medicine should be used with caution in patients with edema due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Ovulation problems

This medicine should be used with caution in premenopausal patients due to the increase in chances of ovulation. Adequate contraceptive measures are recommended for such patients to avoid an unplanned pregnancy.

Bone fractures

This medicine may increase the risk of fractures in some patients. This risk is especially higher in female patients. Close monitoring of bone health is recommended during treatment with this medicine. Replacement with a suitable alternative may be required based on the clinical condition.

Bladder cancer

Use of this medicine has been associated with an increased risk of bladder cancer. It may also worsen the condition of patients suffering from bladder cancer.

Pediatric use

This medicine is not recommended for use in patients less than 18 years of age.

Other anti-diabetic medicines

Report the use of any other anti-diabetic medication, especially insulin to the doctor before beginning treatment with this medicine. Appropriate dose adjustments and close monitoring of blood sugar levels may be required based on the clinical condition of the patient.

Missed Dose

Take the missed dose as soon as you remember. If it is time for the next scheduled dose then the missed dose can be skipped. Do not take two doses within a day to make up for the previous day's missed dose.

Overdose

Contact your doctor immediately if an overdose is suspected. Appropriate supportive measures should be initiated immediately if the symptoms are severe.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.
Interaction with Medicine

Gatifloxacin

Ketoconazole

Gemfibrozil

Aloe Vera

Insulin injection

Disease interactions

Congestive heart failure

This medicine is not recommended for use in patients with a history of congestive heart failure due to the increased risk of worsening of the patient's condition. Close monitoring of heart function and vital signs, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Bladder cancer

This medicine is not recommended for use in patients with an active bladder cancer due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative should be considered under your doctor's supervision.

Liver Disease

This medicine should be used with extreme caution in patients with a known history of liver impairment due to the increased risk of severe adverse effects. Close monitoring of liver function, appropriate dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.

Anemia

This medicine is not recommended for use in patients suffering from anemia since it may worsen the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
You are advised to keep a regular check on the blood sugar levels while taking this medicine. This medicine will show better results if you take a controlled diet and exercise regularly. Your dosage is subject to change based on the response to the medication. This medicine should be taken regularly even when your blood sugar level is low.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine acts on a specific site that positively affects the production of substances that promote the breakdown of glucose and fats in the body. It also decreases the insulin resistance without causing any strain on the pancreas.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Thiazolidinediones

Schedule

Schedule H

DailyMed - Pioglitazone hydrochloride tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 16 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=8f2d7000-37ca-4e09-98ec-07d1c0354cb3

Pioglitazone | C19H20N2O3S - PubChem [Internet]. Pubchem.ncbi.nlm.nih.gov. 2017 [cited 16 March 2017]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/4829#section=Top

Pioglitazone: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 16 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a699016.html

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Information on this page was last updated on 11 May 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.