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Petril Plus (10/0.5 mg) Tablet

Manufactured byMICRO LABS LTD
ContainsEscitalopram (10 mg) + Clonazepam (0.5 mg)
Description

Petril Plus (10/0.5 mg) Tablet is a combination medicine used for the treatment of patients suffering from both depression and anxiety disorders. This medicine is not recommended for use in patients below 18 years of age.

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Side effects

Major & minor side effects for Petril Plus (10/0.5 mg) Tablet

  • Confusion
  • Convulsions
  • Decreased urine output
  • Fast heartbeat
  • Constipation
  • Diarrhea
  • Dry mouth
  • Decreased appetite
  • Joint pain
  • Sleepiness
  • Nervousness
  • Uncontrolled body movements
  • Reduced intellectual abilities
  • Decreased sexual urge
  • Blurred vision
  • Muscle pain

Uses of Petril Plus (10/0.5 mg) Tablet

What is it prescribed for?

  • Comorbid Depression and Anxiety Disorder
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Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The effect of this medicine can be observed within 30 to 40 minutes of administration of the dose.
  • How long do the effects of this medicine last?
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Is it safe to consume alcohol while taking this medicine?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious adverse effects. These side effects may include dizziness, drowsiness, difficulty concentrating, breathing difficulties, etc.
  • Is this a habit forming medicine?
    Habit forming tendencies are reported in some cases, especially if the usage is for an extended period of time. A gradual withdrawal of the drug i.e. decrease in dosing over a period of time is suggested in such cases.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, the infant should be monitored closely for any adverse effects.

Allergy

This medicine is not recommended for use in patients with a known allergy to escitalopram, other SSRIs, clonazepam, other benzodiazepines, or any other inactive ingredients present along with these medicines.

Monoamine oxidase inhibitors

This medicine is not recommended for use in patients undergoing treatment with Monoamine Oxidase Inhibitors (MAOIs) such as selegiline, moclobemide etc. There should be a time gap of at least 14 days between stopping treatment with MAOIs and beginning treatment with this medicine to avoid their interaction.

Pimozide

This medicine is not recommended for use in patients undergoing treatment with pimozide due to increased risk of heart rhythm disorders.

Liver disease

This medicine is not recommended for use in patients with an active liver disease due to the increased risk of worsening of the patient's condition.

Acute angle Glaucoma

This medicine is not recommended for use in patients with a known history of acute angle glaucoma due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, the infant should be monitored closely for any adverse effects.
General warnings

Pediatric population

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Diabetes

This medicine should be used with caution in patients with a known history of diabetes due to the increased risk of altered blood glucose levels. Close monitoring of blood glucose levels is recommended for such patients. Appropriate dose adjustments may be necessary based on the clinical condition of the patient.

Abnormal bleeding

This medicine may increase the risk of abnormal bleeding in some patients. This risk is especially higher in patients with a history of bleeding disorders and patients undergoing treatment with aspirin, NSAIDs, anticoagulants, etc. Report any unusual bleeding or bruising, blood in the stool, etc. to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Impaired kidney function

This medicine should be used with caution in patients with a known history of kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Suicidal tendencies

This medicine may cause suicidal behavior in some patients. This risk is especially higher on the prolonged usage of the medicine. Patients should be monitored closely for any changes in behavior and mood; any such changes should be reported to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Interference with awareness and movements

This medicine may interfere with general awareness and body movements. It is advised that you do not perform any activities such as driving a vehicle or operating heavy machinery during treatment with this medicine.

Withdrawal symptoms

This medicine may cause withdrawal symptoms if the usage is stopped abruptly. This risk is especially higher after a prolonged usage of this medicine. The treatment should be withdrawn gradually under the close supervision of your doctor. Do not stop the use of this medicine without consulting your doctor.

Drug abuse

This medicine should be used with caution in patients with a known history of drug abuse. Chances of dependency are very high, especially if the intended use is for a long duration of time. Patients should be monitored closely for any changes in mood and behavior and any drug-seeking behavior; any such changes should be reported to the doctor immediately.

Increased salivation

This medicine may cause an increase in salivation; caution is advised while administering this medicine to patients with difficulty in handling secretions. This risk is especially higher in patients with respiratory disorders. Report any respiratory disorders to the doctor before beginning treatment with this medicine.

Missed Dose

The missed dose should be taken as soon as possible. It is advisable to skip the missed dose if it is already time for your next scheduled dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious adverse effects. These side effects may include dizziness, drowsiness, difficulty concentrating, breathing difficulties, etc.
Interaction with Medicine

Cimetidine

Lithium

CYP2C19 Inhibitors

CYP450 inducers

Triptans

Disease interactions

Seizure disorders

This medicine should be used with extreme caution in patients with a known history of seizure disorders due to the increased risk of recurrent seizures. Treatment should be discontinued if the patient develops seizures or if there is an increase in the frequency of seizures in patients with a previous diagnosis of epilepsy. Replacement with a suitable alternative should be considered in such cases.

Closed-Angle Glaucoma

This medicine is not recommended for use in patients with a known history of Closed Angle Glaucoma due to the increased risk of worsening of the patient's condition. Replacement with a suitable alternative should be considered under your doctor's supervision.

Respiratory disorders

This medicine should be used with caution in patients with a known history of respiratory disorders since it may worsen the patient's condition. Close monitoring of lung function is recommended for such patients. Replacement with a suitable alternative treatment may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as instructed by your doctor. Taking the right quantity for the right duration is very critical since this medicine may be habit-forming. Close monitoring of the patient for any changes in behavior or mood is recommended during treatment with this medicine. Consult the doctor if you experience any undesirable side effects. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
Escitalopram works by increasing the amount of a chemical substance in the brain which helps in maintaining the psychological balance. Clonazepam works by increasing the activity of certain chemicals which help in decreasing the uncontrolled, excitatory activity in the brain. The combination is thus better effective in treating patients suffering from both depression and anxiety disorders.
Legal Status

Approved

Unknown

Unknown

Unknown

Classification

Category

Selective serotonin reuptake inhibitors, Benzodiazepine anticonvulsants

Schedule

Schedule H

[Internet]. CiplaMed. 2018 [cited 26 February 2018]. Available from:

https://ciplamed.com/content/s-citadep-plus-s-citadep-forte-tablets

[Internet]. 2017 [cited 1 March 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/28957#PRODUCTINFO

Clonazepam: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 1 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a682279.html

DailyMed - clonazepam tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 1 March 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=acbce0e8-5098-4785-943b-8bdb5ff17fab#AB604B8F-25D4-4326-87C6-B92142B765F2

Escitalopram: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 1 March 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a603005.html
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Information on this page was last updated on 26 Feb 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.