Perindopril

Description

Perindopril is used in the treatment of high blood pressure and certain other heart conditions. Patients are advised to follow a strict exercise and diet regimen along with this medicine to get the best possible effect.

Side effects

Major & minor side effects for Perindopril

  • Body pain
  • Chills
  • Cough
  • Nasal congestion
  • Runny Nose
  • Headache
  • Sore throat
  • Abdominal and stomach pain
  • Bladder pain
  • Trouble with swallowing
  • Swelling

Uses of Perindopril

What is it prescribed for?

  • Hypertension
  • Coronary artery disease
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is about 1 to 2 hours after administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is about 24 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to perindopril or any other ACE inhibitor.

Angioedema

This medicine is not recommended for use in patients with a known history of angiotensin converting enzyme inhibitors induced angioedema or hereditary angioedema due to the increased risk of worsening of the patient's condition.

Aliskiren

Coadministration of aliskiren and this medicine is not recommended due to the increased risk of serious adverse effects. This risk is especially higher in the elderly population and in patients with diabetes and kidney diseases.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment (CrCl =< 30 ml/min/1.7 m2) due to the increased risk of serious adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
General warnings

Aliskiren

Perindopril is not recommended for use in combination with aliskiren due to the increased risk of serious side effects. This risk is especially higher in diabetic patients. Replacement with a suitable alternative should be done under your doctor's supervision.

Hypotension

This medicine may cause hypotension, especially when used in combination with other high blood pressure medicines. Regular monitoring of blood pressure is recommended during treatment with this medicine. Appropriate dose adjustments should be done based on the clinical condition.

Hyperkalemia

This medicine may significantly increase the potassium levels in the blood. This may cause serious adverse effects. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Hepatic failure

This medicine should be used with caution in patients with a history of liver diseases due to the increased risk of hepatic failure. Close monitoring of liver function is recommended for such patients. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Surgery and anesthesia

This medicine should be used with caution in patients undergoing surgery or anesthesia due to the increased risk of a very low blood pressure. It is advised that you inform the doctor/surgeon about all your current medications before undergoing any surgery or anesthesia. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Missed Dose

Take the missed dose as soon as you remember it. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Allopurinol

Aliskiren

Insulin

Diclofenac

Candesartan

Disease interactions

Bone marrow suppression

This medicine should be used with caution in patients with bone marrow suppression due to the increased risk of worsening of the patient's condition. Close monitoring of complete blood count is necessary for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Renal Dysfunction

This medicine should be used with caution in patients with kidney diseases due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
It is recommended to avoid a high potassium diet during treatment with this medicine due to the increased risk of serious adverse effects. Your doctor/dietitian will suggest an appropriate diet for you to avoid high intake of potassium.
Lab interactions
Information not available.
Take Perindopril exactly as instructed by the doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by relaxing the blood vessels. This allows the blood to flow smoothly and decreases the blood pressure.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Angiotensin converting enzyme inhibitors

Schedule

Schedule H

[Internet]. 2017 [cited 18 October 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/24873

Perindopril - DrugBank [Internet]. Drugbank.ca. 2017 [cited 18 October 2017]. Available from:

https://www.drugbank.ca/drugs/DB00790

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 18 October 2017]. Available from:

http://www.tga.gov.au/prescribing-medicines-pregnancy-database

Perindopril: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 18 October 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a602017.html

DailyMed - Perindopril erbumine tablet [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 18 October 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fcaefca9-e6ca-4c97-9eb8-7f1c619ce4d0

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Information on this page was last updated on 12 May 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.