Perampanel

Description

Perampanel is an anticonvulsant medicine used for the adjunctive treatment of partial-onset seizures (seizures that affect only one part of the brain) with or without secondarily generalized seizures in patients with epilepsy aged 12 years and older. Take this medicine at the same time regularly. Do not stop taking this medicine suddenly without informing the doctor as it may cause withdrawal symptoms.

Side effects

Major & minor side effects for Perampanel

  • Mood or mental changes
  • Dry mouth
  • Irregular heartbeat
  • Trouble sleeping
  • Unusual tiredness and weakness
  • Sleepiness or unusual drowsiness
  • Unusual thoughts
  • Headache
  • Dizziness
  • Nausea
  • Stomach pain
  • Loss of balance
  • Weight gain

Uses of Perampanel

What is it prescribed for?

  • Seizures
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe side effects such as dizziness, difficulty in concentration, impaired judgment, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
  • Is it habit forming?
    This medicine may be habit-forming.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to perampanel or any other inactive ingredients present along with this medicine.

Severe renal impairment

This medicine is not recommended for use in patients with severe renal impairment due to the increased risk of worsening of the patient's condition.

Severe liver impairment

This medicine is not recommended for use in patients with severe liver impairment due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before taking this medicine.
General warnings

Suicidal tendency

This medicine may increase the risk of suicidal thoughts in some patients. Patients should be monitored closely for any changes in behavior or mood. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Elevated triglycerides

This medicine may increase the triglyceride levels and should be used with caution in patients with high triglyceride levels due to the increased risk of worsening of the patient's condition. Close monitoring of lipid profile tests is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Weight gain

This medicine is likely to cause a gain in weight and hence periodic monitoring is required especially in patients who are obese.

Use in children

This medicine is not recommended for use in patients less than 12 years of age since the safety and efficacy of use are not clinically established.

Driving or operating machinery

This medicine may cause dizziness and drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Withdrawal symptoms

This medicine may cause withdrawal symptoms if the usage is stopped abruptly. This risk is especially higher after prolonged usage of this medicine. The treatment should be withdrawn gradually under the close supervision of your doctor. Do not stop the use of this medicine without consulting your doctor.

Use in elderly population

This medicine should be used with extreme caution in the elderly population due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of severe side effects such as dizziness, difficulty in concentration, impaired judgment, etc. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating machinery if you consume alcohol during treatment with this medicine.
Interaction with Medicine

Buprenorphine

Sodium oxybate

Buspirone

Azatadine

Carbamazepine

Disease interactions

Renal impairment

This medicine should be used with caution in patients with mild to moderate renal impairment due to the increased risk of severe adverse effects. Close monitoring of renal function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition. This medicine is not recommended for use in patients with severe renal impairment or patients undergoing hemodialysis.

Hepatic impairment

This medicine should be used with caution in patients with mild to moderate liver impairment due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition. This medicine is not recommended for use in patients with severe liver impairment.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as prescribed by the doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Causes sleepiness

How it works
It works by binding to the receptors in the brain and inhibits the excitation of brain cells.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

AMPA receptor antagonists, Anticonvulsants

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2018 [cited 14 December 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202834lbl.pdf

Perampanel - DrugBank [Internet]. Drugbank.ca. 2018 [cited 14 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB08883

[Internet]. Medicines.org.uk. 2018 [cited 14 December 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.4276.pdf

DailyMed - Fycompa- perampanel tablet Fycompa- perampanel suspension [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 14 December 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=71cf3309-e182-473c-8b0b-280cabd0e122

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Information on this page was last updated on 31 Jan 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.