Pentosan Polysulfate Sodium

Description

Pentosan Polysulfate Sodium is used for the relief of chronic bladder pain or discomfort associated with interstitial cystitis, a condition of swelling and scarring of the bladder wall. This medicine is not recommended for use in patients less than 16 years of age.

Side effects

Major & minor side effects for Pentosan Polysulfate Sodium

  • Hair loss
  • Diarrhea
  • Nausea
  • Headache
  • Skin rash
  • Indigestion
  • Stomach upset
  • Heartburn
  • Dryness of throat
  • Ringing in ears
  • Mouth sores

Uses of Pentosan Polysulfate Sodium

What is it prescribed for?

  • Interstitial cystitis
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, close monitoring of the infant for any undesired effects is recommended.

Allergy

This medicine is not recommended for use in patients with a known allergy to Pentosan Polysulfate Sodium or any other inactive ingredients present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. If the medicine is used, close monitoring of the infant for any undesired effects is recommended.
General warnings

Use in Children

This medicine is not recommended for use in patients less than 16 years of age since the safety and efficacy of use are not clinically established.

Liver Disease

This medicine should be used with caution in patients suffering from a liver impairment due to the increased risk of severe adverse effects. Close monitoring of liver function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Kidney Disease

This medicine should be used with caution in patients suffering from a kidney impairment due to the increased risk of severe adverse effects. Close monitoring of kidney function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Anticoagulant effect

This medicine is not recommended for use in patients who are at increased risk of bleeding or actively bleed due to the weak anticoagulant effect. This medicine should be used with caution in patients with a history of heparin-induced thrombocytopenia due to the risk of worsening of the condition. Replacement with a suitable alternative may be necessary based on the clinical condition.

Alopecia (Hair loss)

Use of this medicine may cause hair loss in some patients.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amiloride

Warfarin

Spironolactone

Aspirin

Disease interactions

Liver Disease

This medicine should be used with caution in patients with liver diseases due to the increased risk of adverse effects. Regular monitoring of the liver functions tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine exactly as instructed by the doctor. Do not take in larger or smaller amounts than prescribed. Seek emergency medical treatment in case of any severe side effects. Ensure that the course of treatment is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine forms a protective coating to the damaged bladder wall and prevents the irritation of the bladder walls.
Legal Status

Approved

Approved

Unknown

Approved

Classification

Category

Miscellaneous genitourinary tract agents

Schedule

Schedule H

[Internet]. Accessdata.fda.gov. 2018 [cited 27 September 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/020193s009lbl.pdf

DailyMed - ELMIRON- pentosan polysulfate sodium capsule, gelatin coated [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 27 September 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f0ba651e-3d8a-11df-8fbe-119855d89593

Elmiron 100 mg hard capsules - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2018 [cited 27 September 2018]. Available from:

https://www.medicines.org.uk/emc/product/9464

For-IC Capsules [Internet]. CiplaMed. 2018 [cited 27 September 2018]. Available from:

https://ciplamed.com/content/for-ic-capsules

Pentosan Polysulfate - DrugBank [Internet]. Drugbank.ca. 2018 [cited 27 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00686

Pentosan Polysulfate: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 27 September 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a602007.html

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Information on this page was last updated on 11 Jun 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.