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Pemecad 500 mg Injection

Manufactured byCadila Pharmaceuticals Ltd.
ContainsPemetrexed
Description

Pemecad 500 mg Injection is an anticancer agent which is used in the treatment of lung cancer. It should be used under the supervision of a qualified professional. Close monitoring of kidney function and blood cell count is necessary while receiving this medication.

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Side effects

Major & minor side effects for Pemecad 500 mg Injection

  • Low WBC and Platelet count
  • Fever and chills
  • Mouth ulcers
  • Nausea and Vomiting
  • Skin rash
  • Decreased urine output
  • Blood in urine and stools
  • Diarrhea
  • Cough
  • Hair loss
  • Change in mood

Uses of Pemecad 500 mg Injection

What is it prescribed for?

  • Malignant Pleural Mesothelioma
  • Non-Small Cell Lung Cancer
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    The peak effect of this medicine can be observed immediately after intravenous injection.
  • How long do the effects of this medicine last?
    The effect of this medicine lasts for an average duration of 6 to 9 hours.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    No habit forming tendency has reported.
  • Can this medicine be taken during pregnancy?
    This medicine is not recommended for pregnant women.
  • Can this medicine be taken while breast-feeding?
    This medicine is not recommended in breastfeeding women.

Allergy

Not recommended in patients with known allergy to Pemecad 500 mg Injection.
Warnings for special population

Pregnancy

This medicine is not recommended for pregnant women.

Breast-feeding

This medicine is not recommended in breastfeeding women.
General warnings

Premedication

Before starting the treatment, premedication with oral folic acid and intramuscular vitamin B12 is recommended to reduce the severity of hematologic and gastrointestinal toxicity.

Blood cell count

This medicine is known to decrease the neutrophils and platelets count. Blood reports should be obtained before initiating the treatment. The dose of this medicine should be reduced based on the absolute neutrophil count and platelet count.

Skin reactions

The medicine may cause severe skin reactions. To reduce the severity of these reactions, corticosteroids like dexamethasone should be given before, during and after Pemecad 500 mg Injection administration.

Infections

The patients receiving this medicine have a higher chance of developing infections. Hold the chemotherapy and start with broad-spectrum antibiotics if there are any signs and symptoms of fever. Close monitoring of the body temperature and the blood cell count is necessary.

Missed Dose

It is advised not to miss any dose. If you miss any dose, you should contact your doctor immediately.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Clozapine

Live attenuated vaccines and related products

Fluoroquinolone antibiotics

Disease interactions

Impaired kidney function

The medicine should be used with caution in patients with the kidney disease. Close monitoring of kidney function is necessary. It is not recommended in patients with Creatinine Clearance less than 45 ml/min.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is given in multiple cycles. It is important to receive every scheduled dose and make a note of the next scheduled dose. Close monitoring of blood cell counts and kidney function is necessary.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It works by interfering in the DNA synthesis and stops the growth of the cells.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antimetabolites

Schedule

Schedule H

Pemetrexed - DrugBank [Internet]. Drugbank.ca. 2017 [cited 9 June 2017]. Available from:

https://www.drugbank.ca/drugs/DB00642

[Internet]. 2017 [cited 9 June 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/15513

DailyMed - pemetrexed disodium injection, powder, lyophilized, for solution [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 9 June 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f5a860f3-37ec-429c-ae04-9c88d7c55c08

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 9 June 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database
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Information on this page was last updated on 5 Jan 2018

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.