Peginterferon Alfa-2A

Description

Peginterferon Alfa-2A is used for the treatment of chronic conditions of hepatitis C and hepatitis B in patients with compensated liver disease. This medicine is not recommended for use in patients with autoimmune hepatitis.

Side effects

Major & minor side effects for Peginterferon Alfa-2A

  • Depression
  • Irritability
  • Sleeplessness
  • Dizziness
  • Headache
  • Hair loss
  • Blurred vision
  • Dehydration
  • Cough
  • Abdominal pain
  • Dry skin

Uses of Peginterferon Alfa-2A

What is it prescribed for?

  • Chronic Hepatitis C
  • Chronic Hepatitis B
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition

Allergy

This medicine is not recommended for use in patients with a known allergy to interferon alpha or any other inactive ingredients present along with it.

Autoimmune hepatitis

This medicine is not recommended for use in patients with autoimmune hepatitis due to the increased risk of worsening of the patient's condition.

Ribavirin

This medicine is not recommended for use in combination therapy with ribavirin in pregnant women or in men with pregnant female partners due to the increased risk of fetal damage.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition
General warnings

Psychiatric problems

Use of this medicine can cause life-threatening or fatal neuropsychiatric reactions. These include suicide, suicidal tendency, depression, and an increased risk of relapse of recovering drug addicts. Educate the patients and their caregivers to report any symptoms of depression or suicidal tendency to the doctor so that counseling and monitoring of progress can be performed at regular intervals.

Bone marrow suppression

Use of this medicine can cause bone marrow depression. Severe decreases in white blood cell or platelet counts have been reported with this medicine. Close monitoring of blood cell count and symptoms for any infections should be monitored. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Growth retardation in Children

Use of Combination therapy with this medicine is reported to cause growth inhibition and weight loss in pediatric patients.

Severe allergic reactions

This medicine may cause severe allergic reactions. In case of any such reactions, treatment should be discontinued and appropriate medical therapy should be instituted immediately.

Autoimmunity

Use of this medicine can develop different auto-antibodies in the body which may lead to various autoimmune disorders. Close monitoring of symptoms, auto-antibodies, and TSH levels are recommended.

Liver decompensation

Cirrhotic chronic hepatitis C patients co-infected with HIV receiving highly active antiretroviral therapy (HAART) and alpha interferons with or without ribavirin appear to be at increased risk for development of hepatic decompensation compared to patients not receiving HAART. Close monitoring of hepatic function during treatment is necessary and discontinue immediately if decompensation (A Child-Pugh score greater than 6) observed.

Contraception

Use of this medicine in combination with ribavirin may increase the risk of harm to the unborn baby in pregnant women. Effective contraception is advised for the men with female partners and women with the childbearing potential to avoid such risks. Birth controls should be administered while receiving this medicine and for 4-7 months post-therapy to prevent the pregnancy.

Driving or Operating machinery

Use of this medicine may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Missed Dose

Since this medicine is administered in a healthcare setup the chances of missed dose are less. The missed dose of this medicine should be administered as soon as possible. It is advisable to skip the missed dose if it is already the time for your next scheduled dose. Do not double the dose to make up for the missed dose.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Tramadol

Adalimumab

Bexarotene

Clozapine

Deferiprone

Disease interactions

Kidney Disease

This medicine should be used with caution in patients with renal dysfunction due to increased risk of worsening of the condition. Close monitoring of renal function, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Autoimmune disorders

This medicine should be used with extreme caution or should be avoided in patients with autoimmune diseases due to increased risk of worsening of the patient's condition. Close monitoring, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Liver Disease

This medicine should be used with caution in patients with liver dysfunction due to increased risk of worsening of the condition. Close monitoring of liver function, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Cardiovascular disease

This medicine should be used with caution in patients with cardiac dysfunctions such as hypertension, arrhythmias, angina, myocardial infarction, cardiomyopathy, and congestive heart failure due to increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor on priority. Close monitoring of cardiac function, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

CNS disorders

This medicine should be used with caution in patients with seizures, psychiatric disorders or conditions affecting posture or gait due to increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor on priority. Close monitoring, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Thyroid disorders

This medicine should be used with caution in patients with thyroid abnormalities due to increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor on priority. Close monitoring of thyroid levels, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Diabetes Mellitus

This medicine should be used with caution in patients with diabetes mellitus due to increased risk of precipitation of ketoacidosis. Close monitoring of blood glucose, appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Bone marrow suppression

This medicine should be used with caution in patients suffering from bone marrow suppression due to the increased risk of worsening of the patient's condition. Close clinical monitoring of hematopoietic function is recommended. An alternative treatment option should be considered in some cases based on the clinical condition.

Eye disorder

This medicine should be used with caution in patients with eye disorders due to an increased risk of worsening of the patient's condition. Patients should have periodic eye examinations during the treatment. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Lung disease

This medicine should be used with caution in patients with lung diseases due to increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Administer this medicine as advised by the doctor. It should be given in multiple cycles along with other antiviral agents. It is important to receive every scheduled dose. The blood cells, liver function, cardiac function, renal function should be assessed before starting the treatment. Any signs and symptoms of heart and liver dysfunction should be reported to the doctor on priority.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by promoting certain reactions in the infected cells which prevent viral replication and suppression of viral multiplication.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Antiviral interferons

Schedule

Schedule H

[Internet]. Dailymed.nlm.nih.gov. 2018 [cited 19 December 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=de61685e-2b8c-4e22-84bb-869e13600440

[Internet]. Medicines.org.uk. 2018 [cited 19 December 2018]. Available from:

https://www.medicines.org.uk/emc/product/8243/smpc#

Peginterferon alfa-2a - DrugBank [Internet]. Drugbank.ca. 2018 [cited 19 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB00008

[Internet]. Ebs.tga.gov.au. 2018 [cited 19 December 2018]. Available from:

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2010-PI-01158-3

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Information on this page was last updated on 4 Feb 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.