Pazopanib

Description

Pazopanib is an anticancer medicine used for the treatment of advanced kidney cancer and advanced soft tissue sarcoma, a tumor that can occur in and around joints, muscles, tendons, blood vessels, or organs. It is generally used in patients who have not responded to other cancer medicines. This medicine is not recommended for use in patients less than 18 years of age.

Side effects

Major & minor side effects for Pazopanib

  • Blurred vision
  • Chest pain
  • Chills
  • Cough
  • Dizziness
  • Fever
  • Hair loss
  • Headache
  • Nausea and Vomiting
  • Sore throat
  • Weight gain
  • Sweating
  • Drowsiness

Uses of Pazopanib

What is it prescribed for?

  • Advanced Renal Cell Carcinoma (RCC)
  • Advanced Soft Tissue Sarcoma
Read More
Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to pazopanib or any other inactive ingredients present along with it.

Severe Hepatic impairment

This medicine is not recommended for use in patients with severe liver impairment due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.
General warnings

Kidney function impairment

This medicine should be used with caution in patients with kidney diseases, especially in case of severe kidney diseases, due to the increased risk of serious side effects. Close monitoring of kidney function tests is necessary while taking this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Driving or Operating Machinery

This medicine may cause blurred vision or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Bleeding disorders

This medicine should be used with extreme caution in patients with bleeding disorders or any gastrointestinal perforations since it may increase the risk of excessive bleeding. Discontinuation of the therapy with this medicine may be required in such patients based on the clinical condition.

Surgeries

Use of this medicine may be stopped for at least 7 days prior to the surgical procedures because it may impair the wound healing process.

QT Prolongation

This medicine should be used with extreme caution in patients with prolonged QT intervals due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Use in Children

This medicine is not recommended for use in children below 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Atazanavir

Adalimumab

Citalopram

Clozapine

Amiodarone

Cisapride

Disease interactions

Bleeding disorders

This medicine should be used with extreme caution in patients with latent or active bleeding disorders since it may increase the risk of excessive bleeding and worsen the patient's condition. Close monitoring of clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the patient's condition.

Liver Disease

This medicine should be used with caution in patients suffering from mild to moderate liver diseases or patients at risk of liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while taking this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition. This medicine is not recommended for use in patients with severe liver diseases.

Hypertension

This medicine should be used with extreme caution in patients with pre-existing hypertension due to the increased risk of worsening of the patient's condition. Close monitoring of blood pressure levels, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Hypothyroidism

This medicine should be used with caution in patients having a low level of thyroid hormone due to the increased risk of worsening of the patient's condition. Close monitoring of thyroid hormone levels is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Lung dysfunction

This medicine should be used with caution in patients suffering from lung diseases due to the increased risk of worsening of the patient's condition. Close monitoring of lung function tests is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Consumption of grapefruit juice is not recommended during treatment with this medicine due to the increased risk of adverse effects such as liver damage, irregular heart rhythm, high blood pressure, bleeding, etc. Report any unusual symptoms such as dizziness, muscle pain, fever and chills, headache, swelling of hands and feet, vomiting, skin rash, etc. to the doctor immediately.
Lab interactions
Information not available.
Take this medicine at least 1 hour before or 2 hours after a meal. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

To be taken on an empty stomach

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by inhibiting the activity of certain proteins that are necessary for the growth and spread of cancer cells.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

VEGF/VEGFR inhibitors

Schedule

Schedule H

[Internet]. Medicines.org.uk. 2018 [cited 14 September 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.7861.pdf

Pazopanib [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 14 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/Pazopanib

Pazopanib - DrugBank [Internet]. Drugbank.ca. 2018 [cited 14 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB06589

Pazopanib: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2018 [cited 14 September 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a610013.html

[Internet]. Accessdata.fda.gov. 2018 [cited 14 September 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022465lbl.pdf

[Internet]. Us.votrient.com. 2018 [cited 14 September 2018]. Available from:

https://www.us.votrient.com/

[Internet]. India-pharma.gsk.com. 2019 [cited 10 January 2019]. Available from:

https://india-pharma.gsk.com/media/701348/votrient.pdf

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Information on this page was last updated on 11 Jan 2019

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We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.