Paroxet 37.5 MG Tablet

Manufactured byMankind Pharmaceuticals Ltd.
ContainsParoxetine
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Description

Paroxet 37.5 MG Tablet is a medicine that belongs to the selective serotonin reuptake inhibitors (SSRI) group. It is used for the treatment of depression, obsessive-compulsive disorder (OCD), panic disorder, and other anxiety disorders.

Side effects

Major & minor side effects for Paroxet 37.5 MG Tablet

  • Suicidal thinking and behaviour
  • Serotonin syndrome (agitation, hallucinations, seizures, nausea)
  • Irregular heartbeat
  • Shaking of the hands or feet
  • Dizziness when getting up suddenly from a sitting position
  • Chills or cold sweats
  • Blurred vision
  • Nausea and Vomiting
  • Dry mouth and lips
  • Constipation
  • Muscle stiffness
  • Decreased sexual urge
  • Difficulty in passing urine
  • Rapid weight gain/loss
  • Photosensitivity
  • Unusual bleeding or bruising
  • Racing thoughts
  • Reckless behavior
  • Unusual tiredness and weakness

Uses of Paroxet 37.5 MG Tablet

What is it prescribed for?

  • Depression
  • Social Anxiety Disorder
  • Panic disorder
  • Premenstrual Dysphoric Disorder
  • Obsessive Compulsive Disorder
  • Post traumatic stress disorder
  • Generalized anxiety disorder
  • Postmenopausal symptoms
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine is cumulative and may take months to show. It varies depending on the intended use and the dosing.
  • Duration of effect
    The time for which this medicine remains effective in the body is not clearly established. Dosing, duration and the condition for which this medicine is given determine the effective time duration.
  • Safe with alcohol?
    Avoid or limit the uptake of alcohol while using this medicine. It is advised to refrain from driving vehicles and operating heavy machinery while using this medicine.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    Use of this medicine by pregnant women is not recommended as the risk of adverse effect on the fetus is very high. Consult your doctor if you are pregnant or are planning a pregnancy while taking this medicine.
  • Usage while breast-feeding?
    Use of this medicine by breastfeeding women is not recommended unless necessary. If necessary, your doctor may advise you to stop breastfeeding before treatment with this medicine is initiated.

Monoamine oxidase inhibitors (MAOI)

This medicine is not recommended for use while a MAOI medicine (Rasagiline/Selegiline/methylene blue etc.) is being consumed. This medicine should be consumed at least 14 days after stopping the use of MAOI medicines.

Thioridazine

This medicine is not recommended for use if the patient is taking Thioridazine (medicine used to treat schizophrenia).

Pimozide

This medicine is not recommended for use if the patient is taking Pimozide (anti psychotic medicine).

Allergy

This medicine is not recommended for use if you a known history of allergy to Paroxetine or any other ingredient present with it.
Warnings for special population

Pregnancy

Use of this medicine by pregnant women is not recommended as the risk of adverse effect on the fetus is very high. Consult your doctor if you are pregnant or are planning a pregnancy while taking this medicine.

Breast-feeding

Use of this medicine by breastfeeding women is not recommended unless necessary. If necessary, your doctor may advise you to stop breastfeeding before treatment with this medicine is initiated.
General warnings

Suicidal thinking and behavior

Use of this medicine may cause suicidal thought and change the behavior of the user. This risk is increasingly high in young patients. It is recommended to screen the patient for such behavior before starting the treatment. Any change in behavior and thought process after taking this medicine should be reported to the doctor immediately.

Serotonin syndrome

Use of this medicine with other medicines to treat depression may cause nausea, agitation, seizures and hallucinations (symptoms of serotonin syndrome)

Neuroleptic malignant syndrome

Use of this medicine may cause Neuroleptic malignant syndrome characterized by high fever, muscle stiffness, extreme changes in blood pressure, excessive sweating and salivation. The use of this medicine should be stopped as soon as these side effects are experienced.

Hypertension

Use of this medicine is associated with a sharp increase in blood pressure levels. It is recommended to control hypertension using appropriate medicines before starting the treatment with paroxetine.

Bleeding disorders

Use of this medicine may cause unusual bleeding and bruising and hence should be used with caution in patients suffering from bleeding disorders. Use of medicines that are known to cause gastrointestinal bleeding, (example: aspirin, paracetamol, ibuprofen etc), should be avoided while taking paroxetine.

Glaucoma

This medicine should be used with caution in patients suffering from angle closure glaucoma. The symptoms of this disease may worsen upon using paroxetine and hence caution is advised.

Seizure disorder

Use of this medicine may cause seizures and hence should be used with caution in patients suffering from epilepsy.

Manic episodes

Use of this medicine may cause agitation and aggressive behavior in some patients. The patient should be screened for bipolar disorder before starting the treatment course with this medicine.

Heart disease

This medicine should be used with caution in patients suffering from a heart or blood vessel disorder.

Hyponatremia

This medicine may decrease the sodium levels in the body and hence should be used with caution in patients taking diuretic medicines.

Bone fractures

Use of this medicine has been associated with an increase in the incidence of bone fractures. Report any incidence of bone pain to the doctor while taking paroxetine.

Drowsiness and cognitive impairment

Use of this medicine has been associated with drowsiness and impairment of cognition. It is advised to refrain from driving vehicles or operating heavy machinery while taking this medicine.

Sexual dysfunction

Use of this medicine may cause sexual dysfunction. These dysfunctions may include a decrease in libido, erectile disorders, or painful orgasm.

Withdrawal symptoms

Use of this medicine should not be discontinued abruptly. It is advised to gradually reduce the dose of this medicine.

Pediatric use

This medicine is not recommended for use in patients aged below 18 years.

Use in elderly

This medicine should be used with caution in elderly patients as the risk of adverse effects is significantly high.

Missed Dose

Take the missed dose as soon as you remember. If the next scheduled dose is less than 4 hours away, then the missed dose should be skipped.

Overdose

Contact a doctor immediately if an overdose with this medicine is suspected. Symptoms of an overdose may include agitation, hallucinations, convulsions, nausea, drowsiness, fast or slow heartbeat, and convulsions.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Consumption of alcohol while using this medicine can cause an impairment in thinking and judgment. It may also cause dizziness, drowsiness, and lack of concentration.

Instructions

Avoid or limit the uptake of alcohol while using this medicine. It is advised to refrain from driving vehicles and operating heavy machinery while using this medicine.
Interaction with Medicine

Linezolid

Lithium

Ondansetron

Sertraline

Warfarin

Aspirin

Methylene blue

Indinavir

Sumatriptan

Disease interactions

Kidney Disease

This medicine should be used with caution in patients with an impaired kidney function. Suitable dose adjustments should be made based on the serum creatinine levels for moderate to severe impairment.

Glaucoma

This medicine should be used with caution in patients having narrow-angle glaucoma. The symptoms of the disease might worsen if this medicine is used in such patients.

Hypertension

This medicine may cause an increase in the blood pressure levels and hence should be used with caution in patients with hypertension. The blood pressure level should be constantly monitored before and during the course of treatment.

Liver Disease

This medicine should be used with caution in patients with an impaired liver function. Suitable dose adjustments should be made based on the severity of impairment.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Paroxet 37.5 MG Tablet as instructed by the doctor. Do not use in smaller or larger than the recommended dose. The dose is likely to change over time based on your response and hence adherence to the changes is a must. Do not stop the use of this medicine abruptly.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
This medicine works by affecting the level of certain specific chemicals that are imbalanced in people with depression and other anxiety disorders.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Selective serotonin reuptake inhibitors

Schedule

Schedule H

[Internet]. 2017 [cited 4 May 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/26965

DailyMed - Paroxetine hydrochloride hemihydrate tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 4 May 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=899aee24-bd00-ee0a-669d-f4fbe96ef269

Paroxetine - DrugBank [Internet]. Drugbank.ca. 2017 [cited 4 May 2017]. Available from:

https://www.drugbank.ca/drugs/DB00715
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