Parovi Tablet

Manufactured byLUPIN LTD
ContainsParacetamol (500 mg) + Valdecoxib (20 mg)
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Valid on prescription medicines, only for first time user
PRACTO
PRACTO
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Description

Parovi Tablet is a combination medicine used for the treatment of acute pain in adults only. Patients are advised to drink an adequate amount of water during treatment with this medicine to minimize stomach irritation. Close monitoring of liver function is necessary while receiving this medicine. This medicine is not recommended for use in patients less than 18 years of age.

Substitutes

List of substitutes for Parovi Tablet

Side effects

Major & minor side effects for Parovi Tablet

  • Blurred vision
  • Chills
  • Decreased or painful urination
  • Dizziness
  • Nausea and vomiting
  • Nervousness
  • Rapid weight gain
  • Unusual tiredness or weakness
  • Tingling of hands and feet
  • Abdominal and stomach pain
  • Cough
  • Yellow colored eyes or skin
  • Stevens-Johnson Syndrome (A rare, serious disorder of the skin and mucous membranes)
  • Gastric / Mouth Ulcer
  • Bloody and cloudy urine
  • Anemia

Uses of Parovi Tablet

What is it prescribed for?

  • Acute pain
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 1 hour of administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness, rashes, nausea, joint pain, fever, jaundice, etc.
  • Is it habit forming?
    No habit forming tendency has been reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to paracetamol, valdecoxib, any other non-steroidal anti-inflammatory (NSAIDs) drugs, or any other inactive ingredients present along with these medicines.

Coronary Artery Bypass Surgery (CABG)

This medicine is not recommended for use before, during, or after a coronary artery bypass graft surgery due to the increased risk of severe adverse reactions.

Severe Hepatic impairment

This medicine is not recommended for use in patients with a known history of severe liver impairment due to the increased risk of worsening of the patient's condition.

Gastro-intestinal bleeding

This medicine is not recommended for use in patients with a known history of gastrointestinal bleeding since it may worsen the patient's condition.

Congestive Heart Failure

This medicine is not recommended for use in patients with a known history of severe congestive heart failure due to the increased risk of worsening of the patient's condition.

Analgesic Nephropathy (Kidney Disease)

This medicine is not recommended for use in patients suffering from kidney diseases associated with the excessive use of painkillers.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may prescribe a safer alternative based on your clinical condition.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.
General warnings

Ischemic heart disease

This medicine should be used with extreme caution in patients with a known history of ischemic heart diseases due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor immediately. Replacement with a suitable alternative may be necessary based on the clinical condition.

Renal impairment

This medicine should be used with caution in patients with a known history of kidney diseases due to the increased risk of worsening of the patient's condition. Close monitoring of kidney function is necessary during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Gastro-intestinal bleeding

This medicine may cause severe bleeding when taken for a long time. This risk is especially high in the elderly population with a history of gastrointestinal diseases. Report any symptoms of blood in stools and vomiting to the doctor immediately. Replacement with a suitable alternative may be required based on the clinical condition.

Driving or operating machinery

This medicine may cause symptoms such as dizziness in some patients. It is advised that you do not perform any activities that require high mental alertness such as driving a vehicle or operating heavy machinery if you experience dizziness during treatment with this medicine.

Chronic Malnutrition

This medicine should be used with extreme caution in patients suffering from malnourishment due to the increased risk of severe adverse effects. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

N/A

Instructions

Consumption of alcohol is not recommended during treatment with this medicine due to the increased risk of serious side effects such as severe gastrointestinal bleeding, dizziness, fatigue, weakness, rashes, nausea, joint pain, fever, jaundice, etc.
Interaction with Medicine

Carbamazepine

Phenytoin

Sodium Nitrite

Leflunomide

Prilocaine

Adefovir

Ketorolac

Teriflunomide

Tacrolimus

Disease interactions

Alcoholism

This medicine should be used with extreme caution in patients with chronic alcohol use due to the increased risk of serious liver injuries. Close monitoring of liver function is recommended for such patients. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition of the patient.

Liver Disease

This medicine should be used with extreme caution in patients with liver function impairment or active liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Report any symptoms such as nausea, fever, rashes, dark urine, etc. to the doctor on priority. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions

5-HIAA Urine Test

You may get a false-positive result for this test while taking this medicine. It is advised that you inform the doctor and lab technician about all your current medicines including herbs and supplements before undergoing any lab tests.
Take this medicine exactly as prescribed by your doctor. Do not take in larger or smaller amounts than advised/prescribed. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Paracetamol increases the pain threshold and decreases swelling. Valdecoxib works by inhibiting the formation of certain chemical substances in the body that cause pain and swelling.
Legal Status

Banned

Unknown

Unknown

Unknown

Classification

Category

Non-steroidal anti-inflammatory agents

Schedule

N/A

Valdecoxib - DrugBank [Internet]. Drugbank.ca. 2017 [cited 27 December 2017]. Available from:

https://www.drugbank.ca/drugs/DB00580

DailyMed - valdecoxib tablet, film coated [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 27 December 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=caf64301-262c-45ca-acd1-a9d6696c584e

[Internet]. Ec.europa.eu. 2017 [cited 27 December 2017]. Available from:

https://ec.europa.eu/health/documents/community-register/2004/200411258827/anx_8827_en.pdf

[Internet]. 2017 [cited 22 February 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/18127

Acetaminophen: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 22 September 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a681004.html
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