Parnaparin
Description
Parnaparin is an anticoagulant used to prevent the formation and growth of blood clots in patients with certain specific medical conditions. It is also used to prevent blood clots that may potentially form during certain medical procedures.
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Side effects
Major & minor side effects for Parnaparin
- Injection site redness, bruising, or sores
- Unusual bleeding or bruising
- Bloody or coffee colored vomit
- Black or tarry stools
- Dizziness and lightheadedness
- Swelling of eyelids, face, lips, tongue
- Difficulty in breathing
- Back pain
- Muscle weakness
- Fever
- Burning or tingling sensation of skin
- Increased potassium levels
- Increased liver enzyme levels
Uses of Parnaparin
What is it prescribed for?
- Prophylaxis of venous thromboembolism after surgical procedures
- Venous thromboembolic events
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Concerns
Commonly asked questions
- Onset of actionThe effect of this medicine is observed within 30-60 minutes of administration.
- Duration of effectThe effect of this medicine lasts for an average duration of 6-8 hours.
- Safe with alcohol?Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
- Is it habit forming?No habit forming tendencies were reported.
- Usage in pregnancy?This medicine is recommended for use in pregnant women only when absolutely necessary and the potential benefits outweigh the risks involved. Your doctor may determine the best course of treatment after assessing your condition.
- Usage while breast-feeding?This medicine is recommended for use in breastfeeding women only when absolutely necessary and the potential benefits outweigh the risks involved. Your doctor may determine the best course of treatment after assessing your condition.
Allergy
This medicine is not recommended for use in patients with a known allergy to parnaparin or any other inactive ingredient present along with it. Use of this medicine is also not recommended in patients having a known allergy to heparin or pork products.
Active major bleeding
This medicine is not recommended for use in patients with a known heavy active bleeding due to the increased risk of worsening of the patient's condition.
Thrombocytopenia
This medicine is not recommended for use in patients with an abnormally low platelet count due to the increased risk of excessive bleeding.
Hemorrhagic cardiovascular events
This medicine is not recommended for use in patients who are at an increased risk of internal bleeding or hemorrhages due to the risk of worsening of the patient's condition.
Intramuscular route of administration
This medicine is not recommended for administration via the intramuscular route.
Bacterial endocarditis
This medicine is not recommended for use in patients having a swelling of the heart walls or valves due to bacterial infections (bacterial endocarditis).
Warnings for special population
Pregnancy
This medicine is recommended for use in pregnant women only when absolutely necessary and the potential benefits outweigh the risks involved. Your doctor may determine the best course of treatment after assessing your condition.
Breast-feeding
This medicine is recommended for use in breastfeeding women only when absolutely necessary and the potential benefits outweigh the risks involved. Your doctor may determine the best course of treatment after assessing your condition.
General warnings
Hemorrhage and risk factors
Use of this medicine should be initiated only after internal bleeding or hemorrhage and associated risk factors are ruled out. All the underlying causes of bleeding such as peptic ulcer disease, hemophilia, impaired hemostasis, etc. should also be ruled out before the administration of this medicine.
Thrombocytopenia
Use of this medicine may cause low levels of platelets (thrombocytopenia). It is advised to monitor the blood platelet levels at regular intervals while this medicine is administered. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition of the patient.
Other medicines
This medicine may interact with many other medicines and may cause severe side effects. Hence, you are advised to report the use of all medicines including herbs and supplements to the doctor before beginning treatment with this medicine.
Epiduaral/spinal/regional anesthesia
This medicine should not be used in patients receiving regional, epidural, or spinal anesthesia due to the increased risk of excessive bleeding and formation of hematoma.
Interchangeability with other heparins
This medicine should not be used interchangeably with other low molecular weight heparins.
Benzyl alcohol as preservative
Dosage forms containing benzyl alcohol as a preservative should not be administered to neonates, infants, pregnant or breastfeeding women. Benzyl alcohol may cause a fatal adverse event known as Gasping syndrome in neonates and infants.
Missed Dose
This medicine is usually administered in a clinical or hospital setup. However, if you are administering it at home and miss a scheduled dose, then call your doctor immediately for further instructions.
Overdose
Seek emergency medical attention in case of an overdose or suspected overdose. Symptoms may include nosebleed, unusual bruising and bleeding, and the presence of blood in stool or urine.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Lisinopril
Aspirin
Diclofenac
Streptokinase
Dextran
Dipyridamole
Asparaginase
Disease interactions
Hemophilia
This medicine should be administered with extreme caution in patients suffering from hemophilia or other bleeding disorders due to the increased risk of excessive bleeding.
Liver/kidney impairment
This medicine should be used with caution in patients having an impairment of normal liver/kidney function. Appropriate dose adjustments and frequent clinical monitoring are recommended for such patients. Replacement with a suitable alternative may be necessary based on the clinical condition.
Peptic ulcer disease
This medicine should be administered with extreme caution in patients with peptic ulcer disease due to the increased risk of excessive bleeding.
Food interactions
Information not available.
Lab interactions
Information not available.
Administer Parnaparin exactly as instructed by the doctor. It should not be injected into the muscles. It is advised to administer this medicine under the supervision of a doctor in a clinical setup with regular monitoring of blood clotting time and other related parameters. Your doctor may ask you to undergo certain tests to determine the safety of use of this medicine.
Miscelleneous
How it works
This medicine works by interfering with the normal clotting process and decreasing the clot forming ability of the blood.
Legal Status
Classification
Category
Heparins
Schedule
Schedule H
Clinical use of parnaparin in major and minor orthopedic sugery: a review [Internet]. PubMed Central (PMC). 2017 [cited 4 September 2017]. Available from:
D F. Parnaparin. A review of its pharmacology, and clinical application in the prevention and treatment of thromboembolic and other vascular disorders. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2017 [cited 4 September 2017]. Available from:
GM M. Parnaparin : a review of its use in the management of venous thromboembolism, chronic venous disease and other vascular disorders. - PubMed - NCBI [Internet]. Ncbi.nlm.nih.gov. 2017 [cited 4 September 2017]. Available from:
Parnaparin - DrugBank [Internet]. Drugbank.ca. 2017 [cited 4 September 2017]. Available from:
[Internet]. 2017 [cited 4 September 2017]. Available from:
Information on this page was last updated on 4 Sep 2017
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.