Papaverine

Description

Papaverine is a peripheral vasodilator used for the relaxation of smooth muscles which helps them to dilate. It is used to treat muscle spasms of smooth muscles, gastrointestinal tract, urinary system, etc. This medicine is not recommended for use in treating erectile dysfunction due to the increased risk of undesired effects.

Side effects

Major & minor side effects for Papaverine

  • Nausea or Vomiting
  • Dizziness
  • Drowsiness
  • Itching or skin rash
  • Dry mouth
  • Difficulty in ejaculating

Uses of Papaverine

What is it prescribed for?

  • Arterial Spasm
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed rapidly upon parenteral administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to Papaverine, or any other inactive ingredients present in the formulation.

Erectile Dysfuntion

This medicine is not recommended for the use in patients for treating erectile dysfunction due to the increased risk of severe adverse effects.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Administration

When used intravenously, this medicine should be administered by a slow push over 1-2 minutes.

Liver Disease

This medicine should be used with extreme caution in patients with liver disease due to the increased risk of worsening of the patient's condition. Report any unusual symptoms to the doctor on priority. Regular monitoring of liver function tests is necessary for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Glaucoma

This medicine should be used with caution in patients with glaucoma due to the increased risk of adverse effects. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Use in Chidren

This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.

Missed Dose

Since this medicine is usually administered by a qualified healthcare professional in the clinical/hospital setting, the likelihood of a missed dose is very low. If you miss any scheduled session you should contact your doctor immediately and fix an appointment as recommended by your doctor.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very less. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amitriptyline

Bosutinib

Azithromycin

Fluoxetine

Ceritinib

Desipramine

Disease interactions

Complete AV Heart Block

This medicine is not recommended for use in patients with complete atrioventricular heart block due to the increased risk of worsening of the patient's condition. An alternative treatment option should be considered based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Follow all the instructions given by your doctor. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It works by relaxing the smooth muscles of the blood vessels, including the cerebral, peripheral, pulmonary, and coronary arteries; and helps them to dilate.
Legal Status

Approved

Approved

Approved

Unknown

Classification

Category

Peripheral vasodilators

Schedule

Schedule H

DailyMed - PAPAVERINE HYDROCHLORIDE- papaverine hydrochloride injection, solution [Internet]. Dailymed.nlm.nih.gov. 2018 [cited 27 December 2018]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9e5e2ce4-7a57-4c61-a826-64c8d11d038e

Papaverine - DrugBank [Internet]. Drugbank.ca. 2018 [cited 27 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB01113

Papaverine [Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 27 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/papaverine#section=Therapeutic-Uses

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Information on this page was last updated on 27 Aug 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.