Pancuronium

Description

Pancuronium is a muscle relaxant which helps in procedures like endotracheal intubation and cesarean section. It should only be administered by a qualified healthcare professional. Close monitoring of lung function is necessary for patients who receive this medicine. It is very important that you inform the doctor if you have a known allergy to this medicine.

Side effects

Major & minor side effects for Pancuronium

  • Irregular heart beat
  • Difficulty in breathing
  • Vision disturbances
  • Excessive salivation
  • Itching and skin rash
  • Excessive sweating

Uses of Pancuronium

What is it prescribed for?

  • Anesthesia
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 1 to 2 minutes of administration of the dose.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 60 to 100 minutes.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use if you have a known allergy to pancuronium, bromides or any other inactive ingredients present along with it.

Neuromuscular diseases

This medicine is not recommended for use in patients with neuromuscular diseases due to an increase in the risk of worsening of the patient's condition.

Respiratory depression

This medicine is not recommended for use in patients with respiratory depression (slow or declined ability to breathe), in the absence of resuscitative equipment, due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Histamine release

Pancuronium should be used with caution in patients with allergies and asthma due to the increased risk of worsening of the patient's condition. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Paresis

Patients with paresis may require a higher dose of this medicine for an optimal effect.

QT interval prolongation

The combined use of this medicine with other general anesthetic agents may prolong QT interval in pediatric patients. Appropriate dose adjustments and close monitoring of heart and lung function are recommended during treatment with this medicine.

Resistance

Patients with burns, muscle trauma, severe acid-base and/or electrolyte abnormalities may develop resistance to this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be necessary based on the clinical condition.

Myasthenia gravis

This medicine should be used with caution in patients with myasthenia gravis due to the increased risk of respiratory paralysis. Close monitoring of such patients for any worsening of the condition is recommended. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Kidney impairment

This medicine should be used with extreme caution in patients with kidney function impairment due to the increased risk of severe adverse effects. Close monitoring of kidney function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Liver impairment

This medicine should be used with extreme caution in patients with liver function impairment or active liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Missed Dose

Since this medicine is administered before surgery by a qualified healthcare professional, the likelihood of missing a dose is very low.

Overdose

Since this medicine is administered in the hospital setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amikacin

Tobramycin

Amlodipine

Phenytoin

Gentamicin

Disease interactions

Liver Disease

This medicine should be used with extreme caution in patients with liver function impairment or active liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.

Pulmonary impairment

This medicine should be used with caution in patients with a history of pulmonary impairment due to the increased risk of respiratory depression and paralysis. Close monitoring of lung function is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered by a qualified healthcare professional. Inform the doctor if you have a known allergy to this medicine. Report to the doctor all your current medicines including herbs and supplements as well as all your medical conditions before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Causes sleepiness

How it works
It works by relaxing the skeletal muscles and helps in procedures like endotracheal intubation and cesarean section
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Neuromuscular blocking agents

Schedule

Schedule H

[Internet]. Pubchem.ncbi.nlm.nih.gov. 2019 [cited 2 January 2019]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/pancuronium

[Internet]. Drugbank.ca. 2019 [cited 2 January 2019]. Available from:

https://www.drugbank.ca/drugs/DB01337

[Internet]. Medicines.org.uk. 2019 [cited 2 January 2019]. Available from:

https://www.medicines.org.uk/emc/files/pil.3793.pdf

[Internet]. M.betterhealth.vic.gov.au. 2019 [cited 2 January 2019]. Available from:

http://m.betterhealth.vic.gov.au/bhcv2/bhcmed.nsf/pages/CMI5231/$File/CMI5231.pdf

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Information on this page was last updated on 18 Mar 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.