Pancreatin

Description

Pancreatin is a mixture of porcine-derived pancreatic enzymes which include amylases, lipases, and proteases. It is used for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis, pancreatectomy, chronic pancreatitis, or other conditions.

Side effects

Major & minor side effects for Pancreatin

  • Abdominal pain
  • Nausea or Vomiting
  • Diarrhea
  • Constipation
  • Rash
  • Itching

Uses of Pancreatin

What is it prescribed for?

  • Pancreatic insufficiency
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.

Allergy

This medicine is not recommended for use in patients with a known allergy to the porcine-derived pancreatin, or any other inactive ingredients present in the formulation.

Fibrosing colonopathy

This medicine is not recommended for use in patients who are suffering from fibrosing colonopathy due to the increased risk of worsening of the patient's condition.

Gastrointestinal blockage

This medicine is not recommended for use in patients with intestinal blockage disorders due to the increased risk of worsening of the patient's condition.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the drug based on your clinical condition.
General warnings

Hyperuricemia

This medicine should be used with caution in patients with gout, kidney impairment, or hyperuricemia due to the increased risk of a rise in uric acid levels. Regular monitoring of uric acid levels, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Fibrosing colonopathy

This medicine should be used with caution since it may increase the risk of fibrosing colonopathy upon prolonged usage at high doses. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Oral mucosa irritation

Do not crush or retain the tablet/capsule in the mouth due to the increased risk of mucosal irritation. It is advised to not to be crushed or mixed in food having a pH>= 4.5.

Other medicines

This medicine may interact with many other medicines and may cause severe adverse effects. Hence, it is advised that you inform the doctor about all your current medicines including any herbs and supplements before beginning treatment with this medicine.

Missed Dose

Take the missed dose as soon as you remember. If it is almost the time for your next dose, skip the missed dose. Do not double your dose to make up for the missed one.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Sodium Bicarbonate

Miglitol

Acarbose

Magaldrate

Disease interactions

Kidney Disease

This medicine should be used with caution in patients with kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Gout

This medicine should be used with caution in patients with pre-existing gout due to the increased risk of worsening of the patient's condition. Regular monitoring of uric acid levels, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take this medicine as instructed by the doctor. You should adhere to any dose changes instituted by the doctor over the course of treatment. Do not take this medicine in larger or smaller quantities than prescribed. Do not stop the use this medicine without consulting your doctor.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

Does not cause sleepiness

How it works
It works by improving the digestion of food in patients who have inadequate pancreatic enzymes, which are responsible for the breakdown of food.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Digestive enzymes

Schedule

OTC

[Internet]. Medicines.org.uk. 2018 [cited 5 November 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.1168.pdf

CREON® (pancrelipase) Delayed-Release Capsules | Official HCP Site [Internet]. Creon.com. 2018 [cited 5 November 2018]. Available from:

https://www.creon.com/hcp/mechanism-of-action

[Internet]. Hpra.ie. 2018 [cited 5 November 2018]. Available from:

https://www.hpra.ie/img/uploaded/swedocuments/PIL-2172425-27012016121807-635894938901597500.pdf

[Internet]. Medsafe.govt.nz. 2018 [cited 5 November 2018]. Available from:

http://www.medsafe.govt.nz/consumers/cmi/c/Creon.pdf

[Internet]. Rxabbvie.com. 2018 [cited 5 November 2018]. Available from:

https://www.rxabbvie.com/pdf/creon_PI.pdf

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Information on this page was last updated on 28 Aug 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.