Pamidronate

Description

Pamidronate is used to bring down high levels of calcium in the blood that may be caused by some cancers. It is also used to treat Paget's disease of bone, a condition in which the bones are weak, thin, deformed, and easily fractured. In cancer therapy, this medicine can be used to prevent or treat bone damage caused by cancer cells.

Side effects

Major & minor side effects for Pamidronate

  • Black or Tarry stools
  • Blurred vision
  • Chest pain
  • Confusion
  • Dizziness and Drowsiness
  • Fainting
  • Loss of appetite
  • Cough
  • Extreme fatigue
  • Irregular breathing
  • Difficult or painful urination
  • Difficulty in swallowing
  • Itching
  • Redness of the eye
  • Nervousness

Uses of Pamidronate

What is it prescribed for?

  • Hypercalcemia of malignancy
  • Paget's disease
  • Osteolytic bone metastases of breast cancer
  • Osteolytic bone lesions of multiple myeloma
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Concerns

Commonly asked questions

  • Onset of action
    The amount of time required for this medicine to show its action is not clinically established.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to Pamidronate or any other components present along with it.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless absolutely necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Driving or Operating machinery

This medicine may cause dizziness or drowsiness in some patients. It is advised that you do not perform any activities that require high mental alertness like driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this medicine.

Osteonecrosis of the Jaw

This medicine may rarely cause osteonecrosis of the jaw in some patients. This risk is especially higher in patients undergoing invasive dental procedures. Report any unusual symptoms to the doctor immediately. Appropriate dose adjustments or replacement with a suitable alternative may be necessary in some cases based on the clinical condition

Severe bone, joint, and/or muscle pain

This medicine may cause severe bone, joint, and/or muscle pain. Report any such symptoms to the doctor on priority. Your doctor may advise you to discontinue therapy based on your clinical condition.

Thigh and hip bone fracture

Use of this medicine may increase the risk of a thigh and hip bone fracture. Care should be taken to avoid any falls or other trauma to reduce this risk.

Use in children

This medicine is not recommended for use in patients less than 18 years of age since the safety and efficacy of use are not clinically established.

Electrolyte abnormalities

This medicine may cause an imbalance of electrolyte levels in the body and therefore should be used with extreme caution in patients with or who are at risk of developing electrolyte abnormalities due to the increased risk of worsening of the patient's condition. Close monitoring of electrolyte levels is necessary while receiving this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Bone marrow suppression

This medicine should be used with extreme caution in patients with bone marrow suppression due to the increased risk of worsening of the patient's condition. Close monitoring of the clinical condition, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amikacin

Deferasirox

Sirolimus

Methotrexate

Torsemide

Capreomycin

Etecalcetide

Disease interactions

Renal dysfunction

This medicine should be used with caution in patients with renal impairment due to the increased risk of severe adverse effects. Close monitoring of kidney function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered by a qualified healthcare professional. Follow all the instructions given by your doctor and do not miss an appointment to receive this medicine. Consult the doctor if you experience any undesirable effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Causes sleepiness

How it works
This medicine increases bone thickness and reduces the chances of bone breakage.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Calcium metabolism modifier, Bisphosphonates

Schedule

Schedule H

[Internet]. Medlineplus.gov. 2018 [cited 21 December 2018]. Available from:

https://medlineplus.gov/druginfo/meds/a601163.html

[Internet]. Drugbank.ca. 2018 [cited 21 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB00282

[Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 21 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/pamidronate

[Internet]. Medicines.org.uk. 2018 [cited 21 December 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.6453.pdf

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Information on this page was last updated on 7 Feb 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.