Palbociclib
Description
Palbociclib is an anticancer drug used in combination with other medicines to treat certain types of breast cancer. Close monitoring of blood cell count is recommended during treatment with this medicine. This medicine is not recommended for use in patients below 18 years of age.
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Side effects
Major & minor side effects for Palbociclib
- Diarrhea
- Nausea and Vomiting
- Hair loss or thinning of the hair
- Lack or loss of strength
- Decrease in white blood cells and platelets
- Anemia
- Decreased appetite
- Infections
- Chills and fever
- Rashes
Uses of Palbociclib
What is it prescribed for?
- Breast cancer
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Concerns
Commonly asked questions
- Onset of actionThe amount of time required for this medicine to show its action is not clinically established.
- Duration of effectThe amount of time for which this medicine remains active in the body is not clinically established.
- Safe with alcohol?Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
- Is it habit forming?No habit-forming tendencies were reported.
- Usage in pregnancy?This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
- Usage while breast-feeding?This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.
Allergy
This medicine is not recommended for use in patients with a known allergy to palbociclib or any other inactive ingredients present along with it.
Warnings for special population
Pregnancy
This medicine is not recommended for use in pregnant women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine.
Breast-feeding
This medicine is not recommended for use in breastfeeding women unless absolutely necessary. Discuss all the risks and benefits with your doctor before taking this medicine. Your doctor may advise you to discontinue breastfeeding or to discontinue the medicine based on your clinical condition.
General warnings
Neutropenia
This medicine may cause neutropenia (decrease in white blood cells) in some patients. A decrease in white blood cell count may render the patient prone to serious and opportunistic infections. Report any unusual symptoms such as a fever, chills, sore throat, etc. to the doctor immediately. Close monitoring of blood cell counts is recommended during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Infections
Since this medicine can cause bone marrow suppression, the patients are susceptible to serious and opportunistic infections. Report any symptoms such as a fever, chills, shortness of breath, sore throat, etc. to the doctor immediately. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required based on the clinical condition.
Use in children
This medicine is not recommended for use in patients below 18 years of age since the safety and efficacy of use are not clinically established.
Missed Dose
Skip the missed dose and do not take the medicine again until your next scheduled dose. Do not take extra medicine to make up for the missed dose.
Overdose
Seek emergency medical treatment or contact the doctor immediately in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol
Description
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Instructions
Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine
Phenobarbital
Live attenuated vaccines and related products
Fentanyl
Adalimumab
Carbamazepine
Clarithromycin
Disease interactions
Lung dysfunction
This medicine should be used with extreme caution in patients with a history of lung dysfunction since it may worsen the patient's condition. Close monitoring of lung function is recommended for such patients. Appropriate dose adjustments or replacement with a suitable alternative may be required based on the clinical condition.
Hepatic impairment
This medicine should be used with caution in patients with liver function impairment due to the increased risk of severe adverse effects. Close monitoring of liver function is recommended for such patients during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Renal impairment
This medicine should be used with caution in patients with severe renal impairment due to the increased risk of severe adverse effects. Close monitoring of renal function is recommended for such patients during treatment with this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.
Food interactions
Grapefruit may significantly increase the blood levels of this medicine. This may cause severe side effects such as nausea, vomiting, diarrhea, loss of appetite, mouth sores, hair loss, weakness, pain, numbness, etc. Hence, consumption of grapefruit or grapefruit juice is not recommended during treatment with this medicine.
Lab interactions
Information not available.
Take this medicine as instructed by your doctor. Do not take in larger or smaller amounts than advised. Do not miss any scheduled dose. Consult the doctor if you experience any undesirable side effects. Ensure that the treatment course is completed. Do not stop the use of this medicine without consulting your doctor.
Miscelleneous
How it works
Palbociclib blocks the action of certain proteins to slow down the growth and spread of cancer cells. This delays the progression of the disease.
Legal Status
Classification
Category
Kinase inhibitors
Schedule
Schedule H
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[Internet]. Pfizer.com. 2018 [cited 11 January 2018]. Available from:
[Internet]. Accessdata.fda.gov. 2018 [cited 11 January 2018]. Available from:
Information on this page was last updated on 16 Feb 2018
Disclaimer
We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.