Oxytocin

Description

Oxytocin is recommended for use in pregnant women for labor induction or augmentation use and abortion adjunct use. It is also used for the control of postpartum hemorrhage (bleeding). It is not recommended for use unless there is a definite need.

Side effects

Major & minor side effects for Oxytocin

  • Nausea and Vomiting
  • Headache
  • Irregular heartbeat
  • Low blood pressure
  • Convulsions
  • Shortness of breath
  • Abdominal cramps

Uses of Oxytocin

What is it prescribed for?

  • Induction of labor
  • Augmentation of labor
  • Postpartum bleeding
  • Termination of pregnancy
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed immediately after the administration of the dose.
  • Duration of effect
    The effects of this medicine last up to 2 to 3 hours after an intramuscular administration and 1 hour after an intravenous administration.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    Use of this medicine is not recommended for pregnant women other than for the indicated uses such as the induction of labor and termination of pregnancy. Otherwise, the risk of birth defects, abortion, and other abnormalities are very high.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use in patients with a known allergy to oxytocin or any other inactive ingredients present in the formulation.

Hypertonic uterine patterns

This medicine is not recommended for use in case of hypertonic uterine patterns (a complication of labor induction).

Fetal distress

This medicine is not recommended for use in case of fetal distress where delivery is not about to happen.

Cord presentation or prolapse

This medicine is not recommended for use in conditions where vaginal delivery is not appropriate such as cord presentation or prolapse, Vasa Previa, total placenta previa, etc.

Cephalopelvic disproportion

This medicine is not recommended for use in case of cephalopelvic disproportion, a pregnancy complication where the pelvis is inadequate to allow the fetus to easily fit through the pelvic opening.

Cesarean section

This medicine is not recommended for patients who have a history of cesarean section due to the increased risk of adverse effects.
Warnings for special population

Pregnancy

Use of this medicine is not recommended for pregnant women other than for the indicated uses such as the induction of labor and termination of pregnancy. Otherwise, the risk of birth defects, abortion, and other abnormalities are very high.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

For hospital use only

This medicine should be administered only by trained obstetrical personnel in a hospital setting with appropriate obstetrical care facilities.

Uncontrolled hypertension

This medicine should be used with caution in women suffering from uncontrolled hypertension due to the risk of worsening of the condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Cerebrovascular dysfunction

This medicine should be used with caution in women with cerebrovascular dysfunction due to the risk of worsening of the condition. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Volume overload

This medicine may cause volume overload and water intoxication upon administration. Appropriate corrective measures, dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Uterine rupture

This medicine has been associated with cases of uterine rupture when used for labor induction in some cases. Caution is advised while using this medicine if the patient is in the late thirties and beyond or the delivery is cesarean.

Missed Dose

Since this medicine is administered by a qualified healthcare professional in the clinical or hospital setting, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Phenylephrine

Dinoprostone

Atracurium

Dopamine

Midodrine

Disease interactions

Disease

Information not available.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine should be administered only by trained obstetrical personnel in a hospital setting with appropriate obstetrical care facilities. Detect whether the patient is allergic to this medicine before initiating the treatment.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Does not cause sleepiness

How it works
This medicine works by inducing uterine contractions and opening the cervix during labor.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Uterotonic agents

Schedule

Schedule H

[Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 7 September 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/oxytocin

[Internet]. Drugbank.ca. 2018 [cited 7 September 2018]. Available from:

https://www.drugbank.ca/drugs/DB00107

[Internet]. Accessdata.fda.gov. 2018 [cited 7 September 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/077453s000lbl.pdf

[Internet]. Accessdata.fda.gov. 2018 [cited 7 September 2018]. Available from:

https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/018261s031lbl.pdf

[Internet]. Ebs.tga.gov.au. 2018 [cited 7 September 2018]. Available from:

https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2015-PI-01696-1&d=201809071016933

DailyMed - Oxytocin- oxytocin injection [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 3 September 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a9b62187-4141-487c-a9da-f42ad7f9b408

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Information on this page was last updated on 3 Sep 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.