Orlistat

Description

Orlistat is an antiobesity preparations that helps in reducing the weight of obese patients. Take this medicine with each meal containing fat. Proper diet and exercise are necessary to control weight. Multivitamins are recommended while taking this preparation.

Side effects

Major & minor side effects for Orlistat

  • Headache
  • Vomiting
  • Unusual tiredness and weakness
  • Tooth problems
  • Trouble sleeping
  • Itching
  • Yellow colored eyes or skin
  • Abdominal pain
  • abnormal bowel movements
  • Menstrual changes
  • Rectal pain

Uses of Orlistat

What is it prescribed for?

  • Obesity
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed in 24 to 48 hours.
  • Duration of effect
    The effect of this medicine lasts for an average duration of 48 to 72 hours.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for pregnant women.
  • Usage while breast-feeding?
    This medicine is not recommended in breastfeeding women.

Allergy

Not recommended in patients with known allergy to Orlistat.

Chronic malabsorption syndrome

Not recommended in patients with chronic malabsorption syndrome.

Cholestasis

Not recommended in patients with known case of cholestasis.
Warnings for special population

Pregnancy

This medicine is not recommended for pregnant women.

Breast-feeding

This medicine is not recommended in breastfeeding women.
General warnings

Gastrointestinal effects

This medicine may increase the gastrointestinal adverse effects if taken with the meal that contains more than 30% total daily calories from fat (more than 67 g of fat).

Impaired kidney function

This medicine may increase the levels of urinary oxalate in patients and may cause nephrolithiasis and oxalate nephropathy with renal failure. It should be used with caution in patients with the history of kidney impairment. Monitoring of kidney function is necessary.

Impaired liver function

This medicine may cause severe liver injury and which sometimes need liver transplantation.Monitoring of liver function parameters is necessary. Any symptoms of dark urine, light-colored stools, decreased appetite should be reported to the doctor.

Missed Dose

Take the missed dose as soon as you remember unless it is more than 1 hour after the high-fat meal. Skip the missed dose If it’s almost time for your next dose. Do not double your dose to make up for the missed dose.

Overdose

Seek emergency medical treatment or contact the doctor in case of an overdose.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Warfarin

Antidiabetic medicines

Cyclosporine

Disease interactions

Malabsorption

Orlistat may worsen the condition in patients with malabsorption due to the decrease in the absorption of vitamins, minerals, and fats. Therefore not recommended in patients with digestive system disorder and cholestasis.

Diabetes

Orlistat should be used with caution in patients with diabetes due to increase in the risk of low blood glucose levels. The dose of antidiabetic medicines should be reduced based on the clinical condition.
Food interactions
Information not available.
Lab interactions
Information not available.
Take Orlistat with the high-fat meal. Do not take this medicine if you skip the meal or if the meal contains no fat. Low-calorie, low-fat diet, and exercise are needed to control weight. Take multivitamins like A, D, E, K at bedtime prevent further complications.
Miscelleneous

To be taken with food

To be taken as instructed by doctor

May cause sleepiness

How it works
It works by preventing the absorption of fat in the food into the intestine.
Legal Status

Approved

Approved

Approved

Approved

Classification

Category

Peripherally acting antiobesity agents

Schedule

Schedule H

[Internet]. 2017 [cited 12 May 2017]. Available from:

https://www.medicines.org.uk/emc/medicine/27339

Orlistat: MedlinePlus Drug Information [Internet]. Medlineplus.gov. 2017 [cited 12 May 2017]. Available from:

https://medlineplus.gov/druginfo/meds/a601244.html

DailyMed - orlistat capsule [Internet]. Dailymed.nlm.nih.gov. 2017 [cited 12 May 2017]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a2d3bd73-f3af-4ea5-a57c-66b0004cfe4f

Prescribing medicines in pregnancy database [Internet]. Therapeutic Goods Administration (TGA). 2017 [cited 12 May 2017]. Available from:

https://www.tga.gov.au/prescribing-medicines-pregnancy-database#searchname

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Information on this page was last updated on 15 Jan 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.