Norepinephrine

Description

Norepinephrine is used to restore the blood pressure in low blood pressure states often associated with certain medical conditions or surgical procedures. It is also used as an adjunct in the treatment of heart attack (cardiac arrest).

Side effects

Major & minor side effects for Norepinephrine

  • Headache
  • High blood pressure
  • Difficulty in breathing
  • Increased sweating
  • Nausea and vomiting
  • Unusual tiredness or weakness
  • Loss of appetite

Uses of Norepinephrine

What is it prescribed for?

  • Hypotension
  • Cardiac arrest
  • Sepsis or Septic shock
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Concerns

Commonly asked questions

  • Onset of action
    The effect of this medicine can be observed within 1 to 2 minutes of administration of the dose.
  • Duration of effect
    The amount of time for which this medicine remains active in the body is not clinically established.
  • Safe with alcohol?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is it habit forming?
    No habit-forming tendencies were reported.
  • Usage in pregnancy?
    This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
  • Usage while breast-feeding?
    This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Allergy

This medicine is not recommended for use if you have a known allergy to Norepinephrine or any other inactive ingredients present along with it.

Hypotension due to hypovolemia

This medicine is not recommended to treat low blood pressure state resulting from blood volume deficit (hypovolemia).

Peripheral vascular thrombosis

This medicine is not recommended for use in patients with peripheral vascular thrombosis unless in lifesaving procedures.
Warnings for special population

Pregnancy

This medicine is not recommended for use in pregnant women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.

Breast-feeding

This medicine is not recommended for use in breastfeeding women unless necessary. The risks and benefits should be discussed with the doctor before receiving this medicine.
General warnings

Heart rhythm disorders

This medicine should be used with caution in patients with heart rhythm disorders due to the increased risk of severe adverse effects. Close monitoring of the clinical condition, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Hypertension

This medicine may increase the blood pressure levels in some patients during therapy. Close monitoring of blood pressure levels is necessary while receiving this medicine. Appropriate corrective measures, dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Kidney impairment

This medicine should be used with caution in patients with a history of kidney diseases due to the increased risk of severe adverse effects. Close monitoring of kidney function, appropriate dose adjustments, or replacement with a suitable alternative may be required in some cases based on the clinical condition of the patient.

Liver impairment

This medicine should be used with caution in patients suffering from liver diseases due to the increased risk of severe adverse effects. Close monitoring of liver function tests is necessary while receiving this medicine. Appropriate dose adjustments or replacement with a suitable alternative may be required in some cases based on the clinical condition.

Missed Dose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of a missed dose is very low.

Overdose

Since this medicine is administered in the hospital or clinical setting by a qualified healthcare professional, the likelihood of an overdose is very low. However, emergency medical treatment will be initiated by the doctor if an overdose is suspected.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Amitriptyline

Monoamine oxidase inhibitors

Levothyroxine

Beta blockers

Clomipramine

Imipramine

Disease interactions

Peripheral vascular thrombosis

This medicine is not recommended for use in patients with peripheral vascular thrombosis unless absolutely necessary in life- saving condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This medicine is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. Inform the doctor if you have a known allergy to this medicine. Report all your current medicines as well as your medical conditions to the doctor before receiving this medicine.
Miscelleneous

Usage does not depend on food timings

To be taken as instructed by doctor

Effect on sleep is not established

How it works
This medicine works by narrowing the blood vessels in order to increase blood pressure. It also increases heart rate.
Legal Status

Approved

Unknown

Approved

Approved

Classification

Category

Catecholamines, Vasopressors, Alpha adrenergic agonists

Schedule

Schedule H

[Internet]. Pubchem.ncbi.nlm.nih.gov. 2018 [cited 21 December 2018]. Available from:

https://pubchem.ncbi.nlm.nih.gov/compound/norepinephrine

[Internet]. Drugbank.ca. 2018 [cited 21 December 2018]. Available from:

https://www.drugbank.ca/drugs/DB00368

[Internet]. Medicines.org.uk. 2018 [cited 21 December 2018]. Available from:

https://www.medicines.org.uk/emc/files/pil.5353.pdf

Noradrenaline (Norepinephrine) 1 mg/ml Concentrate for Solution for Infusion - Summary of Product Characteristics (SmPC) - (eMC) [Internet]. Medicines.org.uk. 2019 [cited 18 March 2019]. Available from:

https://www.medicines.org.uk/emc/product/4115/smpc

DailyMed - Norepinephrine bitartrate - norepinephrine bitartrate injection [Internet]. Dailymed.nlm.nih.gov. 2019 [cited 18 March 2019]. Available from:

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=a27fb6e0-8f7a-11db-9739-0050c2490048

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Information on this page was last updated on 18 Mar 2019

Disclaimer

We’ve made all possible efforts to ensure that the information provided here is accurate, up-to-date and complete, however, it should not be treated as a substitute for professional medical advice, diagnosis or treatment. Practo only provides reference source for common information on medicines and does not guarantee its accuracy or exhaustiveness. The absence of a warning for any drug or combination thereof, should not be assumed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Practo does not assume any responsibility for any aspect of healthcare administered with the aid of information provided above. If you have any doubts about your medication then we strongly recommend that you consult with your doctor, nurse or healthcare provider. See detailed T&C here.