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Nizonide-O Oral Suspension
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Nizonide-O Oral Suspension

Manufactured byLUPIN LTD
ContainsNitazoxanide (100 mg/5 ml) + Ofloxacin (50 mg/5 ml)
Description
Nizonide-O Oral Suspension is a combination of Nitazoxanide and Ofloxacin. It is used orally to treat diarrhoea caused by bacteria, parasites (micro-organisms that live in other's bodies and use their body's nutrients to reproduce). Nitazoxanide kills parasites by interfering with their energy production and ofloxacin kills bacteria by blocking their reproduction process. The common side effects of Nizonide-O Oral Suspension use are nausea, vomiting, headache and stomach pain. Usually, these side effects are self-resolving. Consult your doctor if any of these side effects persist or worsen. Discontinue Nizonide-O Oral Suspension and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing. You can take Nizonide-O Oral Suspension with or without food. Take your medicine on time to maintain its steady levels in your body. Avoid consuming this medicine more than the prescribed dose as an overdose may harm you. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection come back and harder to treat. Nizonide-O Oral Suspension may cause dizziness. Refrain yourself from driving and operating a machine if you feel dizzy after taking this medicine. Avoid the consumption of alcohol while taking this medicine as it can cause dizziness. Use Nizonide-O Oral Suspension cautiously if you are having tendon rupture (injuries) and brain disorder. To make sure Nizonide-O Oral Suspension is safe for you, share your entire medical and medication history with your doctor before using this medicine. Inform your doctor if you are pregnant, planning a pregnancy or are breastfeeding.
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Side effectsConcernsUsageRelated products

Side effects

Major & minor side effects for Nizonide-O Oral Suspension

  • Stomach pain
  • Nausea and vomiting
  • Headache
  • Dizziness
  • Urine discoloration
  • Skin rash and itching
  • Anxiety
  • Confusion
  • Fever
  • Decreased appetite
  • Joint pain
  • Change in taste

Uses of Nizonide-O Oral Suspension

What is it prescribed for?

  • Diarrhoea
Read More
Concerns

Commonly asked questions

  • How long does it take for this medicine to take effect?
    Nizonide-O Oral Suspension start showing its effect in 1-2 hours once taken orally. However, it may take few days to make you feel better.
  • How long do the effects of this medicine last?
    The amount of time for which Nizonide-O Oral Suspension remains active in your body is not known.
  • Is it safe to consume alcohol while taking this medicine?
    Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
  • Is this a habit forming medicine?
    Nizonide-O Oral Suspension has no habit-forming tendency.
  • Can this medicine be taken during pregnancy?
    Nizonide-O Oral Suspension is not recommended for use in pregnancy unless absolutely necessary.
  • Can this medicine be taken while breast-feeding?
    Nizonide-O Oral Suspension is not recommended for use if you are breastfeeding. You may be advised by your doctor to discontinue breastfeeding while taking this medicine. Once breastfeeding gets resumed after the therapy, the baby should be observed for diarrhoea and yeast infection.

Allergy

Avoid taking Nizonide-O Oral Suspension if you are previously allergic to it. Seek an immediate medical attention if you notice any symptoms such as skin rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, breathing difficulties, etc.

Tendinitis or tendon rupture

Tendon rupture or tendinitis is a condition in which the tissue connecting muscles to your bones becomes inflamed. Nizonide-O Oral Suspension is not recommended in this condition due to the increased risk of worsening your condition.

Myasthenia gravis

Myasthenia gravis is a rare autoimmune brain disorder characterized by weakness and rapid fatigue of any of your muscles under voluntary control. It may worsen with time if not treated properly. Nizonide-O Oral Suspension is not recommended due to the increased risk of worsening your condition.
Warnings for special population

Pregnancy

Nizonide-O Oral Suspension is not recommended for use in pregnancy unless absolutely necessary.

Breast-feeding

Nizonide-O Oral Suspension is not recommended for use if you are breastfeeding. You may be advised by your doctor to discontinue breastfeeding while taking this medicine. Once breastfeeding gets resumed after the therapy, the baby should be observed for diarrhoea and yeast infection.
General warnings

Liver impairment

Nizonide-O Oral Suspension gets converted into its active form in your liver. An impaired liver cannot convert this medicine properly and accumulation of this medicine takes place in your liver. This accumulation may worsen your liver condition.

Use in children

Nizonide-O Oral Suspension is not recommended for use in babies below 1 year of age since the safety and efficacy of this medicine have not been clinically established.

Other uses

Your doctor may prescribe Nizonide-O Oral Suspension for indications other than those stated above in certain specific circumstances, especially if other medicines are ineffective. All the risks and benefits should be discussed with your doctor in such cases.

Antibiotic-resistance

Avoid Nizonide-O Oral Suspension without sufficient proof or suspicion of a bacterial infection. Improper dosing might fail in providing benefits and may even cause toxicity. It may also increase the risk of the development of bacteria that are antibiotic-resistant.

Driving or Operating machinery

Use of Nizonide-O Oral Suspension may cause symptoms such as blurred vision, confusion, dizziness, etc. It is advised that you do not perform any activities such as driving a vehicle or operating machinery.

Photosensitivity

Nizonide-O Oral Suspension may make you highly sensitive to sunlight or UV (ultraviolet) radiation. You are advised to use sunscreen and wear protective clothing to avoid adverse reactions to sunlight during treatment with this medicine.

Muscle damage

Nizonide-O Oral Suspension can cause muscle damage usually on the tendons that surround your ankle. Inform your doctor if you feel pain, numbness, or tingling sensations in your muscles

Missed Dose

If you forget to take a Nizonide-O Oral Suspension dose, make sure that you remember to take your next dose on time. Do not take two doses together to make up for a forgotten dose.

Overdose

Never take Nizonide-O Oral Suspension more than the prescribed dose. If you suspect that you might have taken an overdose of this medicine, go to the emergency department of your local hospital.
All drugs interact differently for person to person. You should check all the possible interactions with your doctor before starting any medicine.
Interaction with Alcohol

Description

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

Instructions

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Interaction with Medicine

Insulin

NSAIDs

Antacids containing calcium/magnesium/aluminum

Probenecid

Cyclosporine

Warfarin

Disease interactions

Central nervous system disorders

Nizonide-O Oral Suspension should be used in caution if you have a brain disorder. It may also cause dizziness, confusion, seizures, etc.

QT Prolongation

Nizonide-O Oral Suspension may affect your heart. It causes QT prolongation (changes in ECG of your heart). Use it cautiously if you are having a history of QT prolongation.

Kidney Disease

Nizonide-O Oral Suspension is excreted by kidneys. An impaired kidney cannot filter out this medicine properly and accumulation of this medicine takes place in your kidneys. This accumulation can worsen your kidney condition.
Food interactions
Information not available.
Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.
You can take Nizonide-O Oral Suspension with or without food. Take Nizonide-O Oral Suspension timely to maintain steady levels in your body. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection come back and harder to treat. Discontinue Nizonide-O Oral Suspension and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing. It is advisable to drink plenty of fluids and a healthy diet while taking the medicine. It may cause dizziness. Do not drive or do anything that requires mental focus until you know how the medicine affects you.
Miscelleneous

Can be taken with or without food, as advised by your doctor

To be taken as instructed by doctor

May cause sleepiness

How it works
Nizonide-O Oral Suspension is a combination of Nitazoxanide and Ofloxacin. Ofloxacin works by inhibiting an enzyme required for the bacterial DNA to replicate, thus inhibiting bacterial cell division. Nitazoxanide interferes with the energy production of the parasites and prevents its growth that causes diarrhoea.
Legal Status

Banned

Unknown

Unknown

Unknown

Classification

Category

Gastrointestinal agents, Quinolones

Schedule

Schedule H

Pubchem.ncbi.nlm.nih.gov. 2021. Ofloxacin. [online] Available at: < [Accessed 20 August 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/4583>

Pubchem.ncbi.nlm.nih.gov. 2021. Nitazoxanide. [online] Available at: < [Accessed 20 August 2021].

https://pubchem.ncbi.nlm.nih.gov/compound/41684>

Accessdata.fda.gov. 2021. [online] Available at: < [Accessed 20 August 2021].

https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/021818lbl.pdf>

Drugs, H., 2021. Ofloxacin: MedlinePlus Drug Information. [online] Medlineplus.gov. Available at: < [Accessed 20 August 2021].

https://medlineplus.gov/druginfo/meds/a691005.html>
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Information on this page was last updated on 23 Aug 2021

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